DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9003 and pof2

DIOPT Version :9

Sequence 1:	NP_001097271.1	Gene:	CG9003 / 36244	FlyBaseID:	FBgn0033639	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_596079.1	Gene:	pof2 / 2540355	PomBaseID:	SPBC25B2.11	Length:	463	Species:	Schizosaccharomyces pombe

Alignment Length:	451	Identity:	110/451 - (24%)
Similarity:	194/451 - (43%)	Gaps:	89/451 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 QLPKEVLLRVFSYLDVVSLCRC-AQVCKYWNVLALDGSSWQKI---------NLFD---FQRDIE 293
            ::|.||...:.|||:...| || :.||..|....:. :.|:|:         |.||   :.:|:.
pombe     2 RVPNEVCFNILSYLEADEL-RCKSTVCTSWRNFIIP-TLWEKVVFQNEAQLNNFFDTLQYSKDVS 64

  Fly   294 --GPVIENIS-QRCRGFLKSLSLRGCQSVGDQSVRTLANHCHNIEHLDLSDCKKITDISTQSISR 355
              ...:..:: .|.|.||....|         .:.|||.   .|..|:||.|.:|::.....:..
pombe    65 YYFRYLRKLNCSRVRKFLTDKHL---------MLMTLAT---GISRLNLSGCTRISEPLIGKLLY 117

  Fly   356 YCSKLTAINLHSCSNITDNSLKYLSDGCPNLMEINVSWCHLISENGVEALARGCVKLRKFSSKGC 420
            ....|..||..:..::..|.|:|:||.||||..:|:..|.|:.:.|:..:.:.|..|.:.....|
pombe   118 QNLNLVTINFSNIFSLPANILEYISDNCPNLKALNIGNCGLVEDTGMVQIIKRCPYLNRLIIPNC 182

  Fly   421 KQINDNAIMCLAKYCPDLMVLNLHSCE-------------------------------------- 447
            :::.|.::..|::. .||:.|::..||
pombe   183 RKLTDVSLQILSEK-EDLIELDISGCEGFHNADTLSRLVSRNRGLKELSMDGCTELSHFITFLNL 246

  Fly   448 ----------------TITDSSIRQLAANCHKLQKLCVSKCADLTDLTLLSLSQHNHLLNTLEVS 496
                            .:.||.|..:.....||..|.:|||..|||.:||||::.:..|.||.:.
pombe   247 NCELDAMRALSLNNLPDLKDSDIELITCKFSKLNSLFLSKCIGLTDSSLLSLTKLSQSLTTLHLG 311

  Fly   497 GCRNFTDIGFQALGRNCKYLERMDLEECSQITDLTLAHLATGCPSLEKLTLSHCELITDDGIRHL 561
            .|...||||.|.|.::||.:..:|...|.:::|:.::.:|. .|.|:::.|..|..:||..: .|
pombe   312 HCYEITDIGVQCLLKSCKNITYIDFGGCLRLSDIAVSAIAK-LPYLQRVGLVKCICLTDLSV-IL 374

  Fly   562 TTGSCAAEILSVLELDNCPLITDRTLEHLV-SCHNLQRIELFDCQLITRTAIRKLKNHLPN 621
            .:||.:.. |..:.|..|..:|.:::.:|: :|..|:.:.:.....|..|.:|.....:|:
pombe   375 LSGSFSRN-LERVHLSYCIGLTAKSVSYLMYNCKTLKHLSVTGINSILCTELRSFSRPIPD 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9003	NP_001097271.1	F-box-like	240..285	CDD:289689	14/52 (27%)
		leucine-rich repeat	280..307	CDD:275381	8/41 (20%)
		AMN1	<308..453	CDD:187754	38/198 (19%)
		leucine-rich repeat	308..327	CDD:275381	2/18 (11%)
		leucine-rich repeat	334..359	CDD:275381	6/24 (25%)
		leucine-rich repeat	360..385	CDD:275381	9/24 (38%)
		leucine-rich repeat	386..411	CDD:275381	6/24 (25%)
		AMN1	<409..586	CDD:187754	55/230 (24%)
		leucine-rich repeat	412..437	CDD:275381	4/24 (17%)
		leucine-rich repeat	438..463	CDD:275381	7/78 (9%)
		leucine-rich repeat	464..515	CDD:275381	23/50 (46%)
		leucine-rich repeat	516..541	CDD:275381	4/24 (17%)
		leucine-rich repeat	542..561	CDD:275381	5/18 (28%)
		leucine-rich repeat	571..595	CDD:275381	6/24 (25%)
		leucine-rich repeat	596..621	CDD:275381	4/24 (17%)
pof2	NP_596079.1	F-box-like	2..45	CDD:289689	14/44 (32%)
		leucine-rich repeat	96..121	CDD:275381	6/24 (25%)
		leucine-rich repeat	122..141	CDD:275381	5/18 (28%)
		AMN1	<143..292	CDD:187754	29/149 (19%)
		leucine-rich repeat	148..173	CDD:275381	6/24 (25%)
		leucine-rich repeat	174..225	CDD:275381	9/51 (18%)
		leucine-rich repeat	226..278	CDD:275381	3/51 (6%)
		AMN1	<278..428	CDD:187754	48/152 (32%)
		leucine-rich repeat	279..304	CDD:275381	12/24 (50%)
		leucine-rich repeat	305..330	CDD:275381	11/24 (46%)
		leucine-rich repeat	331..355	CDD:275381	4/24 (17%)
		leucine-rich repeat	356..382	CDD:275381	8/26 (31%)
		leucine-rich repeat	383..408	CDD:275381	6/24 (25%)
		leucine-rich repeat	409..427	CDD:275381	3/17 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68784
Inparanoid	1	1.050	116	1.000	Inparanoid score	I1532
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47209
orthoMCL	1	0.900	-	-		OOG6_101086
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2139
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.890