DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9003 and FBXL13

DIOPT Version :9

Sequence 1:	NP_001097271.1	Gene:	CG9003 / 36244	FlyBaseID:	FBgn0033639	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	NP_001381423.1	Gene:	FBXL13 / 222235	HGNCID:	21658	Length:	825	Species:	Homo sapiens

Alignment Length:	564	Identity:	136/564 - (24%)
Similarity:	229/564 - (40%)	Gaps:	166/564 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 QRNMAGSAQDQSEDQSQTFLGATELDDEL---IKQLPKEVLLRVFSYLDVVSLCRCAQVCKYWNV 272
            :|..|..:.......|:.||    :|:.|   |..||:..:|::|.||.:..:..|.||...|.:
Human   217 KRAAAEESNFPERSSSEVFL----VDETLKCDISLLPERAILQIFFYLSLKDVIICGQVNHAWML 277

  Fly   273 LALDGSSWQKINLFDFQRDIEGPVIENISQRCRGFLKSLSLRGCQSVGDQSVRTLANHCHNIEHL 337
            :....|.|..|:....:..|....|.:..||.|..:..|:.||| .:..::.|:: :||.|::.|
Human   278 MTQLNSLWNAIDFSSVKNVIPDKYIVSTLQRWRLNVLRLNFRGC-LLRPKTFRSV-SHCRNLQEL 340

  Fly   338 DLSDCKKITDISTQSISRYCSKLTAINLHS-------------------------CSNITDNSLK 377
            ::|||...||.|.:.||..|..:..:||.:                         |...||..|:
Human   341 NVSDCPTFTDESMRHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQNLSLAYCRRFTDKGLQ 405

  Fly   378 YLS--DGCPNLMEINVSWC-------------------HL-------ISENGVEALARGC----- 409
            ||:  :||..|:.:::|.|                   ||       :::|.|:||...|
Human   406 YLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITS 470

  Fly   410 -------------------VKLRKFSSKGCKQINDNAIMCLAKYCPDLMVLNLHSCETITDSSIR 455
                               .||||...:|.|::.|.:...:.|..|:|..:.:..|:.|||||:|
Human   471 LVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLR 535

  Fly   456 QLA----------ANC-----------------HKLQKLCVSKCADLTDLTLLSLSQH------- 486
            .|:          |||                 .::::|.:|.|..|:|.:::.||:.
Human   536 SLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYL 600

  Fly   487 -----NHL-------------------------------------LNTLEVSGCRNFTDIGFQAL 509
                 .||                                     |..|.||.|...||.|.||.
Human   601 SLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDISNEGLNVLSRHKKLKELSVSECYRITDDGIQAF 665

  Fly   510 GRNCKYLERMDLEECSQITDLTLAHLATGCPSLEKLTLSHCELITDDGIRHLTTGSCAAEILSVL 574
            .::...||.:|:..|||::|:.:..||..|.:|..|:::.|..|||..:..|   |.....|.:|
Human   666 CKSSLILEHLDVSYCSQLSDMIIKALAIYCINLTSLSIAGCPKITDSAMEML---SAKCHYLHIL 727

  Fly   575 ELDNCPLITDRTLEHL-VSCHNLQRIELFDCQLITRTAIRKLKN 617
            ::..|.|:||:.||.| :.|..|:.:::..|..|::.|.:::.:
Human   728 DISGCVLLTDQILEDLQIGCKQLRILKMQYCTNISKKAAQRMSS 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9003	NP_001097271.1	F-box-like	240..285	CDD:289689	14/44 (32%)
		leucine-rich repeat	280..307	CDD:275381	7/26 (27%)
		AMN1	<308..453	CDD:187754	52/221 (24%)
		leucine-rich repeat	308..327	CDD:275381	5/18 (28%)
		leucine-rich repeat	334..359	CDD:275381	10/24 (42%)
		leucine-rich repeat	360..385	CDD:275381	10/51 (20%)
		leucine-rich repeat	386..411	CDD:275381	10/74 (14%)
		AMN1	<409..586	CDD:187754	65/276 (24%)
		leucine-rich repeat	412..437	CDD:275381	7/24 (29%)
		leucine-rich repeat	438..463	CDD:275381	12/51 (24%)
		leucine-rich repeat	464..515	CDD:275381	19/99 (19%)
		leucine-rich repeat	516..541	CDD:275381	10/24 (42%)
		leucine-rich repeat	542..561	CDD:275381	6/18 (33%)
		leucine-rich repeat	571..595	CDD:275381	10/24 (42%)
		leucine-rich repeat	596..621	CDD:275381	4/22 (18%)
FBXL13	NP_001381423.1	Sfi1	<112..>224	CDD:400658	2/6 (33%)
		F-box-like	245..289	CDD:403981	13/43 (30%)
		leucine-rich repeat	285..312	CDD:275381	7/26 (27%)
		AMN1	312..497	CDD:187754	42/186 (23%)
		leucine-rich repeat	313..336	CDD:275381	7/24 (29%)
		leucine-rich repeat	337..362	CDD:275381	10/24 (42%)
		leucine-rich repeat	363..387	CDD:275381	2/23 (9%)
		leucine-rich repeat	388..406	CDD:275381	4/17 (24%)
		leucine-rich repeat	416..441	CDD:275381	3/24 (13%)
		leucine-rich repeat	442..491	CDD:275381	7/48 (15%)
		leucine-rich repeat	468..490	CDD:275381	0/21 (0%)
		leucine-rich repeat	492..515	CDD:275381	7/22 (32%)
		leucine-rich repeat	518..542	CDD:275381	9/23 (39%)
		AMN1	529..737	CDD:187754	51/210 (24%)
		leucine-rich repeat	543..570	CDD:275381	3/26 (12%)
		leucine-rich repeat	571..596	CDD:275381	7/24 (29%)
		leucine-rich repeat	597..645	CDD:275381	2/47 (4%)
		leucine-rich repeat	646..671	CDD:275381	10/24 (42%)
		leucine-rich repeat	672..697	CDD:275381	10/24 (42%)
		leucine-rich repeat	698..723	CDD:275381	8/27 (30%)
		leucine-rich repeat	724..749	CDD:275381	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153026
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2139
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.870