DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG9003 and Fbxl14

DIOPT Version :9

Sequence 1:NP_001097271.1 Gene:CG9003 / 36244 FlyBaseID:FBgn0033639 Length:651 Species:Drosophila melanogaster
Sequence 2:NP_598701.2 Gene:Fbxl14 / 101358 MGIID:2141676 Length:400 Species:Mus musculus


Alignment Length:407 Identity:114/407 - (28%)
Similarity:187/407 - (45%) Gaps:60/407 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   246 EVLLRVFSYLDVVSLCRCAQVCKYWNVLALDGSSW-------------------------QKINL 285
            |:|..:|.||||....|.||||..|...|...|.|                         :::.:
Mouse    11 ELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPSLFPSLQARGIRRVQI 75

  Fly   286 FDFQRDIEGPVIENISQRCRGFLKSLSLRGCQSVGDQSV-RTLANHCHNIEHLDLSDCKKITDIS 349
            ...:|.: ..||:.::.     ::||:|.||.::.|..: ........::..|:||.||:|||.|
Mouse    76 LSLRRSL-SYVIQGMAN-----IESLNLSGCYNLTDNGLGHAFVQEIGSLRALNLSLCKQITDSS 134

  Fly   350 TQSISRYCSKLTAINLHSCSNITDNSLKYLSDGCPNLMEINVSWCHLISENGVEALARGCVKLRK 414
            ...|::|...|..:.|..|||||:..|..::.|...|..:|:..|..:|:.|:..||    .:.:
Mouse   135 LGRIAQYLKGLEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLSDVGIGHLA----GMTR 195

  Fly   415 FSSKGCKQINDNAIMCLAKYCPDLMVLNLHSCETITDSSIRQLAANCHKLQKLCVSKCADLTDLT 479
            .:::||..:..               |.|..|:.:||.|::.::.....|:.|.:|.|..::|..
Mouse   196 SAAEGCLGLEQ---------------LTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISDAG 245

  Fly   480 LLSLSQHNHLLNTLEVSGCRNFTDIGFQALGRNCKYLERMDLEECSQITDLTLAHLATGCPSLEK 544
            ||.|| |...|.:|.:..|.|.:|.|...|......|..:|:..|.::.|.:||::|.|...|:.
Mouse   246 LLHLS-HMGSLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSLAYIAQGLDGLKS 309

  Fly   545 LTLSHCELITDDGIRHLTTGSCAAEILSVLELDNCPLITDRTLEHLVSCH--NLQRIELFDCQLI 607
            |:|..|. |:||||..:..   ....|..|.:..|..|||:.|| |::.|  .|..|:|:.|..|
Mouse   310 LSLCSCH-ISDDGINRMVR---QMHGLRTLNIGQCVRITDKGLE-LIAEHLSQLTGIDLYGCTRI 369

  Fly   608 TRTAIRKLKNHLPNIKV 624
            |:..:.:: ..||.:||
Mouse   370 TKRGLERI-TQLPCLKV 385

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG9003NP_001097271.1 F-box-like 240..285 CDD:289689 16/63 (25%)
leucine-rich repeat 280..307 CDD:275381 4/51 (8%)
AMN1 <308..453 CDD:187754 40/145 (28%)
leucine-rich repeat 308..327 CDD:275381 6/19 (32%)
leucine-rich repeat 334..359 CDD:275381 11/24 (46%)
leucine-rich repeat 360..385 CDD:275381 9/24 (38%)
leucine-rich repeat 386..411 CDD:275381 7/24 (29%)
AMN1 <409..586 CDD:187754 48/176 (27%)
leucine-rich repeat 412..437 CDD:275381 2/24 (8%)
leucine-rich repeat 438..463 CDD:275381 6/24 (25%)
leucine-rich repeat 464..515 CDD:275381 17/50 (34%)
leucine-rich repeat 516..541 CDD:275381 8/24 (33%)
leucine-rich repeat 542..561 CDD:275381 9/18 (50%)
leucine-rich repeat 571..595 CDD:275381 10/25 (40%)
leucine-rich repeat 596..621 CDD:275381 7/24 (29%)
Fbxl14NP_598701.2 Required for down-regulation of SNAI1. /evidence=ECO:0000250 2..48 16/36 (44%)
F-box-like 5..46 CDD:403981 15/34 (44%)
AMN1 90..296 CDD:187754 62/230 (27%)
leucine-rich repeat 92..118 CDD:275381 6/25 (24%)
leucine-rich repeat 119..142 CDD:275381 10/22 (45%)
LRR 1 144..163 8/18 (44%)
leucine-rich repeat 145..170 CDD:275381 9/24 (38%)
LRR 2 170..191 5/20 (25%)
leucine-rich repeat 171..203 CDD:275381 9/35 (26%)
LRR 3 203..225 6/36 (17%)
leucine-rich repeat 204..229 CDD:275381 6/39 (15%)
AMN1 228..395 CDD:187754 54/165 (33%)
LRR 4 229..250 7/20 (35%)
leucine-rich repeat 230..254 CDD:275381 10/24 (42%)
LRR 5 254..275 6/20 (30%)
leucine-rich repeat 255..280 CDD:275381 7/24 (29%)
leucine-rich repeat 281..306 CDD:275381 8/24 (33%)
leucine-rich repeat 307..331 CDD:275381 9/27 (33%)
leucine-rich repeat 332..357 CDD:275381 10/25 (40%)
leucine-rich repeat 358..382 CDD:275381 7/24 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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