DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9003 and si:dkey-192l18.9

DIOPT Version :9

Sequence 1:	NP_001097271.1	Gene:	CG9003 / 36244	FlyBaseID:	FBgn0033639	Length:	651	Species:	Drosophila melanogaster
Sequence 2:	XP_001344855.1	Gene:	si:dkey-192l18.9 / 100005961	ZFINID:	ZDB-GENE-120709-25	Length:	476	Species:	Danio rerio

Alignment Length:	545	Identity:	147/545 - (26%)
Similarity:	233/545 - (42%)	Gaps:	100/545 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 GNNHNPSLQLNGNGGSNTRQHSSGSNSRQHSSSSSNSNSSNISPPPSSSSSSRSNNN-------N 147
            |.|:....:..|.|.|:.  .|..|:|.:|:.|.|:.|::      :|..|.:|...       |
Zfish     2 GANNGKQCESEGKGSSSI--SSDVSSSTEHTPSKSHKNAA------TSEDSDQSMRTPSPALILN 58

  Fly   148 NNHSSNIISGFCSTIWRSATFGSATPVINPLPAVSINPKIMESSSDSCSLSSSTTPDVGLADQQR 212
            .|....:.:|      |.::.|....:|:|.||               :.|.||.|.
Zfish    59 PNPPQTVPNG------RESSLGETVALIHPPPA---------------TRSKSTKPP-------- 94

  Fly   213 NMAGSAQDQSEDQSQTFLGATELDDELIKQLPKEVLLRVFSYLDVVSLCRCAQVCKYWNVLALDG 277
                                   ...||..||..|||.:.|||....||.||:||:.|..|:.|.
Zfish    95 -----------------------HTALIDILPDPVLLHILSYLSTPHLCLCARVCRRWYNLSWDP 136

  Fly   278 SSWQKINLFDFQRDIEGPVIENISQRCRGFLKSLSLRGCQSVGDQSVRTLANHCHNIEHLDLSDC 342
            ..|..|.|       .|.::.  :.|.   ||.|:.|.||..        .|.|..:|.:..|.|
Zfish   137 RLWSTIRL-------NGELLN--ADRA---LKVLTHRLCQDT--------PNVCLTLETVVASGC 181

  Fly   343 KKITDISTQSISRYCSKLTAINLHSCSNITDNSLKYLSDGCPNLMEINVSWC------HLISENG 401
            ::::|...:.|:|.|.:|..:.:..|.|::::::..:...||||..::||.|      .|..|..
Zfish   182 RRLSDRGLRVIARCCPELRCLEVAGCYNVSNDAVFDVVSKCPNLEHLDVSGCPKVTCISLTEEGS 246

  Fly   402 VE--ALARGCVKLRKFSSKGCKQINDNAIMCLAKYCPDLMVLNLHSCETITDSSIRQLAANCHKL 464
            |:  .|....:.||..:...|..:.|..:..:|.:||.|..|.|..|..|||.|:||||.:|..|
Zfish   247 VQHTPLHGQQIGLRYLNMTDCVSLEDKGLKTIAIHCPRLTHLYLRRCIRITDESLRQLALHCTAL 311

  Fly   465 QKLCVSKCADLTDLTLLSLSQHNHLLNTLEVSGCRNFTDIGFQALGRNCKYLERMDLEECSQITD 529
            ::|.:|.|..:.|..|..:::....|..|.|:.|...||:|.:.:.|.|..|..::...|..:||
Zfish   312 RELSLSDCHLVGDFGLREVARLEGRLRYLSVAHCMRITDVGLRYVARYCPRLRYLNARGCEGLTD 376

  Fly   530 LTLAHLATGCPSLEKLTLSHCELITDDGIRHLTTGSCAAEILSVLELDNCPLITDRTLEHLV-SC 593
            ..|::||..||.|..:.:..|.|::|.|:..|  ..| .::|..|.|..|..:|.|.|..|. .|
Zfish   377 QGLSYLARNCPRLRSIDVGRCPLVSDAGLEVL--AHC-CKMLRRLSLRGCESLTGRGLMALAEGC 438

  Fly   594 HNLQRIELFDCQLITRTAIRKLKNH 618
            ..||.:.:.:|. :...|:|.::.|
Zfish   439 PELQLLNVQECD-VPPEALRLVRQH 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9003	NP_001097271.1	F-box-like	240..285	CDD:289689	20/44 (45%)
		leucine-rich repeat	280..307	CDD:275381	5/26 (19%)
		AMN1	<308..453	CDD:187754	43/152 (28%)
		leucine-rich repeat	308..327	CDD:275381	6/18 (33%)
		leucine-rich repeat	334..359	CDD:275381	7/24 (29%)
		leucine-rich repeat	360..385	CDD:275381	4/24 (17%)
		leucine-rich repeat	386..411	CDD:275381	8/32 (25%)
		AMN1	<409..586	CDD:187754	56/176 (32%)
		leucine-rich repeat	412..437	CDD:275381	6/24 (25%)
		leucine-rich repeat	438..463	CDD:275381	13/24 (54%)
		leucine-rich repeat	464..515	CDD:275381	15/50 (30%)
		leucine-rich repeat	516..541	CDD:275381	8/24 (33%)
		leucine-rich repeat	542..561	CDD:275381	5/18 (28%)
		leucine-rich repeat	571..595	CDD:275381	9/24 (38%)
		leucine-rich repeat	596..621	CDD:275381	6/23 (26%)
si:dkey-192l18.9	XP_001344855.1	F-box-like	99..145	CDD:289689	21/52 (40%)
		leucine-rich repeat	114..138	CDD:275381	10/23 (43%)
		leucine-rich repeat	139..172	CDD:275381	13/52 (25%)
		leucine-rich repeat	173..198	CDD:275381	7/24 (29%)
		leucine-rich repeat	199..220	CDD:275381	3/20 (15%)
		LRR_CC	222..246	CDD:197685	9/23 (39%)
		leucine-rich repeat	225..258	CDD:275381	8/32 (25%)
		leucine-rich repeat	259..284	CDD:275381	6/24 (25%)
		AMN1	280..465	CDD:187754	61/187 (33%)
		leucine-rich repeat	285..310	CDD:275381	13/24 (54%)
		leucine-rich repeat	311..336	CDD:275381	6/24 (25%)
		leucine-rich repeat	337..362	CDD:275381	9/24 (38%)
		leucine-rich repeat	363..388	CDD:275381	8/24 (33%)
		leucine-rich repeat	389..414	CDD:275381	7/27 (26%)
		leucine-rich repeat	415..440	CDD:275381	9/24 (38%)
		leucine-rich repeat	441..465	CDD:275381	6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588045
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52856
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2139
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.880