Protein Alignment CG9005 and FAM214A

DIOPT Version :9

• Sequence 1: NP_001369081.1
• Gene: CG9005 / 36243
• FlyBaseID: FBgn0033638
• Length: 1338
• Species: Drosophila melanogaster
• Sequence 2: NP_001273424.1
• Gene: FAM214A / 56204
• HGNCID: 25609
• Length: 1083
• Species: Homo sapiens
• Alignment Length: 1215
• Identity: 270/1215 - (22%)
• Similarity: 413/1215 - (33%)
• Gaps: 454/1215 - (37%)

  Fly   333 EHICDMSYVNMTCNRWRAYCMKMEAILARREPVCIEVYL---------GPVSH------------ 376
            :|.|......  |.:.|....::..:.....|:.:|:.|         ||.:.
Human    65 KHECSDKLAQ--CRQARRTRSEVTLLWKNNLPIMVEMMLLPDCCYSDDGPTTEGIDLNDPAIKQD 127

  Fly   377 KLLLEQWIICGREKVPPPT----MTLPSLCSAIRSQLYFSQIVAWCDLLRKCDPSVYDSGRVIFS 437
            .||||:||:   |.||...    :...:|..|:||.::|||:.||
Human   128 ALLLERWIL---EPVPRQNGDRFIEEKTLLLAVRSFVFFSQLSAW-------------------- 169

  Fly   438 NCGNNAGDLATSYTTCGGQKRPRLNIFYRIKQHTTTNSNSGLHQEDGFSAKANVHNFPNVNVSES 502
                    |:.|:...     || ||.|||       |.:.:..:..||.....|.||..|||.:
Human   170 --------LSVSHGAI-----PR-NILYRI-------SAADVDLQWNFSQTPIEHVFPVPNVSHN 213

  Fly   503 YSISVSVRSLPR------------INGGL------PHVEPLPPSPAPRSLRPCGGDPAS------ 543
            .::.|||:||||            .|.||      .|.........|.....||.:.:.
Human   214 VALKVSVQSLPRQSNYPVLTCSIHTNIGLYEKRIQQHKLKTHQHHNPNEAEQCGTNSSQRLCSKQ 278

  Fly   544 --TPTGGGGLHAATPTGLGARTSALTPTTTAG----------GSNCDNGK--------PGMGQIL 588
              |......|||         .|..:|..||.          ||..|:|.        .|:|.|.
Human   279 TWTMAPESVLHA---------KSGPSPEYTAAVKNIKLYPGTGSKSDHGTSQANILGFSGIGDIK 334

  Fly   589 DELDG----------DTSLSHR-------------------ERQ--LQKYRKRMQRRD------- 615
            .:...          |:|:|:|                   |||  :.:..:.:...|
Human   335 SQETSVRTLKSFSMVDSSISNRQSFWQSAGETNPLIGSLIQERQEIIARIAQHLIHCDPSTSHVS 399

  Fly   616 ----KKRERKATPDRLNSRQQSEEPMDEGEE--SQT------------------------QSQT- 649
                ..:|..:...:|....|..|.:.:|:|  |.|                        :|:|
Human   400 GRPFNTQESSSLHSKLFRVSQENENVGKGKEAFSMTFGSPEFSSPEDTNEGKIRLKPETPRSETC 464

  Fly   650 ----------TSETQSLALTLQQPRR--IAMI-------------------------STGTQTSL 677
                      ..||..|..:|.|.|:  ||.|                         |..::...
Human   465 ISNDFYSHMPVGETNPLIGSLLQERQDVIARIAQHLEHIDPTASHIPRQSFNMHDSSSVASKVFR 529

  Fly   678 SSCQQCGSEKTLL------------CLSCTGGGGAHGGSNGTAN----GSTNGATD--------- 717
            ||.:    :|.||            ...|:..|....|.|...|    ...|.:.:
Human   530 SSYE----DKNLLKKNKDESSVSISHTKCSLLGDISDGKNLVPNKCFTSFKNNSKEKCSLKHQTR 590

  Fly   718 ---DGDDSDTTASEMEET--SSCSLSSADLIVGTPRNNAELLLQAIQRTPKNRNRKPHPG--VLD 775
               ..:.|:...|..:||  .|.|||::.::.....||.:|..:..::...|...|.:..  .:|
Human   591 NQCQNNPSEIIQSTYQETQNKSSSLSTSSILSQHKENNLDLTSRFKEQEMSNGIDKQYSNCTTID 655

  Fly   776 QVSCRN--------------------ADLNGGQNNNLLKAT-----------PATSGCQVCKR-- 807
            :..|.|                    :| :..:|::.:|.|           .:.|..:..||
Human   656 KQICTNKYKEKIINENYNPKFFGNLQSD-DSKKNDSKIKVTVLEMSEYLNKYESMSSNKDSKRPK 719

  Fly   808 ---QKTQHNFANGKVHQPTNGKQASNGYASMHLEAEKQPDVVQILATKLTP--NIERCSLNPVER 867
               |.||.|.....:::...|.:.... ..:..|.:||.|.....:...:.  :|:.|    :..
Human   720 TCEQNTQLNSIENYLNKDNEGFKCKKS-DQLKNEQDKQEDPTNEKSQNYSQRRSIKDC----LST 779

  Fly   868 CKTPPPGVADHIVVQFKTPLSQVPAKHQPDAMVPLQQQQLGKSSSKPAQLRLNCGSNLLESETPP 932
            |:.|.           .|.:.:...||                            ||:.......
Human   780 CEQPK-----------NTEVLRTTLKH----------------------------SNVWRKHNFH 805

  Fly   933 PMTSPQMRKALPKVNLTTIFCSSAPI-----AIGCPAFSFDPAALSHARSQLLAPDVSVTPPVQK 992
            .:.....|...|:..|..:   |:|:     ..||  |..| ::|.|.                |
Human   806 SLDGTSTRAFHPQTGLPLL---SSPVPQRKTQSGC--FDLD-SSLLHL----------------K 848

  Fly   993 SFSAPTLPHAASLSVSPRFSKQALAAHKRRSRHLSDRSDRSSLGSDEQLSDEDLESGLCSPAGGS 1057
            |||:                                ||.|..|..::   |.|:.......:...
Human   849 SFSS--------------------------------RSPRPCLNIED---DPDIHEKPFLSSSAP 878

  Fly  1058 PLKCRARLAAQFGGRPLLGNLEESLLQRRLMPKIEVMGFTLQLGASGGFCPTQVNIPAVSYFYEL 1122
            |:...:          ||||.|||:|..|..|...|.|||.::||||.||||.:.:|....||.:
Human   879 PITSLS----------LLGNFEESVLNYRFDPLGIVDGFTAEVGASGAFCPTHLTLPVEVSFYSV 933

  Fly  1123 HGETLSTPYLCEIRLP---RKGYSVPRSGTVQATLLNPIGTVVRMFVIPYDMRDMPPLHRTFIRQ 1184
            ..:...:||:..|.|.   ::||.||.|||:|.||.||..|||:|||:.||:||||..|:||:||
Human   934 SDDNAPSPYMGVITLESLGKRGYRVPPSGTIQVTLFNPNKTVVKMFVVIYDLRDMPANHQTFLRQ 998

  Fly  1185 RILAEELSQDQDEGHKVPRS---PTVTSTTSKLGHFISAEQMKRLRYSIHLKFQTSRSGRLCLHT 1246
            |..:..:.|:      |.||   ..:..|..:|           |||.|||:||:|:||::.||.
Human   999 RTFSVPVKQE------VKRSVNKENIRHTEERL-----------LRYLIHLRFQSSKSGKIYLHR 1046

  Fly  1247 DIRLLISRRT-DCDTAAAHAKGVLEAPNELVTDTMMPAEPRYSAR 1290
            |:|||.||:: :.|:.||:         ||.:.|..|..|::|.|
Human  1047 DVRLLFSRKSMEVDSGAAY---------ELKSYTESPTNPQFSPR 1082

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9005	NP_001369081.1	DUF4210	1074..1131	CDD:404751	25/56 (45%)
		Chromosome_seg	1226..1290	CDD:404729	28/64 (44%)
FAM214A	NP_001273424.1	TroA-like	<477..>527	CDD:294188	10/49 (20%)
		DUF4210	885..942	CDD:290626	25/56 (45%)
		Chromosome_seg	1025..1082	CDD:290600	29/76 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	71	1.000	Domainoid score	I9456
eggNOG	1	0.900	-	-		E1_KOG2306
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	195	1.000	Inparanoid score	I3832
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002608
OrthoInspector	1	1.000	-	-		otm41591
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13199
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1702
SonicParanoid	1	1.000	-	-		X5857
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.950