DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9005 and Fam214b

DIOPT Version :9

Sequence 1:	NP_001369081.1	Gene:	CG9005 / 36243	FlyBaseID:	FBgn0033638	Length:	1338	Species:	Drosophila melanogaster
Sequence 2:	NP_001013953.1	Gene:	Fam214b / 298201	RGDID:	1311249	Length:	538	Species:	Rattus norvegicus

Alignment Length:	783	Identity:	197/783 - (25%)
Similarity:	268/783 - (34%)	Gaps:	265/783 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   521 HVE-PLPPSPAPRSLRPCGGDPASTPTGGGGLHAATPTGLGARTSALTPTTTAGGSNCDNGKPGM 584
            ||: .|.||..|.:      .|:..|...|.|......|.          :.|||:.    .||:
  Rat     3 HVQAELSPSSEPEA------GPSQPPVTQGTLQGGLLMGY----------SPAGGAT----SPGV 47

  Fly   585 GQILDELDGDTSLSHRERQLQKYRKRMQRRDKKRERKATPDRLNSRQQSEEPMDEGEESQTQSQT 649
            .|: ........:|...|.|   ::.....:..||.|..|. |.:|:
  Rat    48 YQV-SIFSPSAGVSEPPRAL---KRPAPSTEGPRELKRGPG-LGARE------------------ 89

  Fly   650 TSETQSLALTLQQPRRIAMIS-TGTQTSLSSCQQCGSEKTLLCLSCTGGGGAHGGSNGTANGSTN 713
                   .|..::|..:.::| .|....|....|..|.              ||.......||..
  Rat    90 -------GLPPEEPSTVGLVSPEGLGLGLGVASQHFSH--------------HGLRVVEQGGSAT 133

  Fly   714 GATDDGDDSDTTASEMEETSSC-SLSSADLIVGTPRNNAELLLQAIQRTPKNRNRKPHPGVLDQV 777
            .:...|..|....|   ..:|| :|.:.|.  ..|....:..|          ...|.|....|:
  Rat   134 SSWTSGTQSTPWPS---SNASCNTLHTRDW--AFPDQGGQGCL----------GESPGPAPSGQL 183

  Fly   778 SCRNADLN-----GGQNNNLLKATPATSGCQVCKRQKTQHNFANGKVHQPTNGKQASNGYASMHL 837
            ...:.||:     ||      |:..|..|              ||....|......:||::..|
  Rat   184 HTLDTDLHNLAQIGG------KSPVARVG--------------NGSNPWPRESHGTANGHSPEH- 227

  Fly   838 EAEKQPDVVQILATKLTPNIERCSLNPVERCKTPP-PGVADHIVVQFKTPLSQVPAKHQPDAMVP 901
                                            ||| ||                     |....|
  Rat   228 --------------------------------TPPGPG---------------------PPGPCP 239

  Fly   902 LQQQQLGKSSSKPAQLRLNCGSNLLESETPPPMTSPQMRKALPKVNLTTIFCSSAPIAIGCP--A 964
            .:::.|      ||...|:..|   |.|.|    :|:.|:.                .:|||  |
  Rat   240 TKRRLL------PAGEALDVSS---EDEGP----APRRRRG----------------TLGCPLAA 275

  Fly   965 FSFDPAALSHARSQLLAPDVSVTPPVQKSFSAPTLPHAASLSVSPRFSKQALAAHKRRSRHLSDR 1029
            .|.|..|.......|..|...|..|..:|.....|..|..|.:|                  |.|
  Rat   276 NSSDAKATPFWSHLLPGPKEPVLDPTDRSPMGRRLKGARRLKLS------------------SLR 322

  Fly  1030 SDRSSLGSDEQLSDEDLESGLCSPAGGSPLKCRARLAAQFGGRPLLGNLEESLLQRRLMPKIEVM 1094
            :.|..             .||.||...||....|      ..|.||||.|||||:.|..|...:.
  Rat   323 TLRKG-------------PGLLSPPSASPFPTPA------VSRTLLGNFEESLLRGRFAPSGHIE 368

  Fly  1095 GFTLQLGASGGFCPTQVNIPAVSYFYELHGETLSTPYLCEI---RLPRKGYSVPRSGTVQATLLN 1156
            |||.::||||.:||..|.:|....|:::..:....|:|..:   .|.|||||||:.||:|.||.|
  Rat   369 GFTAEIGASGSYCPQHVTLPVTVTFFDVSEQNAPAPFLGVVDLNPLGRKGYSVPKVGTIQVTLFN 433

  Fly  1157 PIGTVVRMFVIPYDMRDMPPLHRTFIRQRILAEELSQDQDEGHKVPRSPTVTSTTSKLGHFISAE 1221
            |..|||:||::.:|..|||..|.||:|.|:....:.   :||:        .|.|.:|
  Rat   434 PNQTVVKMFLVTFDFSDMPAAHMTFLRHRLFLVPVG---EEGN--------VSPTHRL------- 480

  Fly  1222 QMKRLRYSIHLKFQTSRSGRLCLHTDIRLLISRRT-DCDTAAAHAKGVLEAPNELVTDTMMPAEP 1285
                |.|.:||:|::||||||.||.|||||.|||: :.||.         .|.||...|..|..|
  Rat   481 ----LCYLLHLRFRSSRSGRLSLHGDIRLLFSRRSLELDTG---------LPYELQAVTEAPHNP 532

  Fly  1286 RYS 1288
            |||
  Rat   533 RYS 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9005	NP_001369081.1	DUF4210	1074..1131	CDD:404751	23/56 (41%)
CG9005	NP_001369081.1	Chromosome_seg	1226..1290	CDD:404729	32/64 (50%)
Fam214b	NP_001013953.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..103		28/149 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	130..149		5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..185		5/31 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	199..272		27/169 (16%)
		DUF4210	348..405	CDD:404751	23/56 (41%)
		Chromosome_seg	480..536	CDD:404729	33/76 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9405
eggNOG	1	0.900	-	-		E1_KOG2306
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002608
OrthoInspector	1	1.000	-	-		otm45715
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13199
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.910