DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Egm and Acox3

DIOPT Version :9

Sequence 1:NP_610687.1 Gene:Egm / 36242 FlyBaseID:FBgn0086712 Length:639 Species:Drosophila melanogaster
Sequence 2:XP_006504259.1 Gene:Acox3 / 80911 MGIID:1933156 Length:755 Species:Mus musculus


Alignment Length:595 Identity:102/595 - (17%)
Similarity:186/595 - (31%) Gaps:226/595 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   184 RYLQDLATGKLIGTEAIYEIS-PPEEDYFNTTAELFPEYGKWQLNGEKSFVICTPG-ERQLF--- 243
            :||:.:.:.::.|..|:.|:| ........|||...|:        .:.|::.:|. |...|   
Mouse   142 KYLEKIYSLEIFGCFALTELSHGSNTKAMRTTAHYDPD--------TQEFILHSPDFEAAKFWVG 198

  Fly   244 ---------LVLAQTQQPNVPGVLGR--GTTIFLVDSQ-------QEGVRLGEKHATFGCRKAEI 290
                     :|.||...|:     |:  |...|||..:       ..||.:|:.....|....:.
Mouse   199 NLGKTATHAVVFAQLYMPD-----GQCHGLHSFLVQIRDTKTLLPMTGVMVGDIGKKLGQNGLDN 258

  Fly   291 RRVHFEGVKLGEDQVVGLPHDGNRYSEQLVRS------SRLRGSLVGLSLAK-----------KL 338
            ....|..|::....:  |...||..||....|      .||..||..||..:           ||
Mouse   259 GFAMFNKVRIPRQNL--LDRTGNITSEGTYNSPFKDVRQRLGASLGSLSSGRISIISMSVVNLKL 321

  Fly   339 LNELA-QYTVNTTQCG------VQLQDLELTRIHMSRAMCSVYAME---SMLYL------TAGLL 387
            ...:| :::....|.|      :.:.:..|.:..:...:.:.||::   ..:::      :|.|.
Mouse   322 AVSIAIRFSATRCQFGPTDKEEIPVLEYPLQQWRILPYLAAAYALDHFSKTIFMDLIEVQSARLR 386

  Fly   388 DEFRAQDVTLESAITKYFTLRQVYAIAS------------------------------------- 415
            .:...|...|.         |:::|:||                                     
Mouse   387 GDHSDQQAELG---------REIHALASAGKPLASWTAQRGIQECREACGGHGYLAMNRFGDLRN 442

  Fly   416 ---QNLGVVGPKSLLSGETT-------ELGLRDAAQLCTQGESLDTLGMFIALTGLQHAGQA--- 467
               .|....|..::|..:|:       |..|:|.|...:..:::|.|..:..:.|.:..|.:   
Mouse   443 DNDPNCTYEGDNNVLLQQTSNYLLSLLEPPLQDGAHFTSPLKTVDFLEAYPGILGQKFLGSSKAD 507

  Fly   468 -MNTGV-----------------------RKSRNPLF---NPGHIFGKFLDNNSIDNPKTKMQLS 505
             |::..                       :|||...|   |...::|                  
Mouse   508 WMDSAAPLAAYRWLVCYLLQESHRRYCQEKKSRGSDFEARNNSQVYG------------------ 554

  Fly   506 EHVHPSLEAAAQCIELSVARLQMAVELMFTKHGNAVVERQSEMQRLAEVGTLIYAMWASVARASR 570
                        |..|::|.:::.|...|.:|.::.....|....|..:.|| |.:|        
Mouse   555 ------------CRPLALAFMELTVMQRFHEHIHSSGLSPSLRTVLGRLSTL-YGLW-------- 598

  Fly   571 SYCIGLPLA-----------------DHELLTATAICSEGRDRVRTLCTEIYGGHFVNNDNNLVR 618
              |:...:|                 :..:||   :|.:.:|....|...|....||        
Mouse   599 --CLSQHMALLYRGGYISGEQTGRAMEDAILT---LCEQLKDDAVALVDVIAPSDFV-------- 650

  Fly   619 LSKQVAKSKG 628
            |:..:||:.|
Mouse   651 LNSPIAKADG 660

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgmNP_610687.1 ACAD 92..457 CDD:173838 67/375 (18%)
CaiA 122..439 CDD:224871 63/357 (18%)
Acox3XP_006504259.1 AXO 19..663 CDD:173839 102/595 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1960
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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