DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Egm and acad9

DIOPT Version :9

Sequence 1:	NP_610687.1	Gene:	Egm / 36242	FlyBaseID:	FBgn0086712	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001038772.1	Gene:	acad9 / 724002	ZFINID:	ZDB-GENE-060616-196	Length:	630	Species:	Danio rerio

Alignment Length:	598	Identity:	169/598 - (28%)
Similarity:	287/598 - (47%)	Gaps:	45/598 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 AKNFFIGVVD-KELLAYPEVIPRDEMAQLENSLLPLKNYFVEPRETEETS------PET---LRQ 124
            ||:.|:|.|: ||:..||| |..:|:.:|...:.|::.:|.|..::.:..      |||   |::
Zfish    50 AKDLFLGKVNKKEVFPYPE-ISNEELEELNQFVQPVEKFFNESVDSAKIDREANIPPETLDGLKE 113

  Fly   125 LGLYGLNVSTDYEGKGYGWSASLMASEPDSTDINVTLGLQTHRVVVDLLKEV---GTPLQQQRYL 186
            |||:|:.:..:|.|.|...:......|..|.|.::.:.|..|:.:.  ||.:   ||..|:.:||
Zfish   114 LGLFGIQIPEEYGGLGLSNTMYARLGEITSLDGSIAVTLAAHQAIG--LKGILIAGTDAQKAKYL 176

  Fly   187 QDLATGKLIGTEAIYEISPPEEDYFNTTAEL---FPEYGK-WQLNGEKSFVICTPGERQLFLVLA 247
            ..||||:.|   |.:.::.|.......:.:|   ..|.|| :.|||.| |.|...|...:..|.|
Zfish   177 PKLATGEHI---AAFCLTEPGSGSDAASIQLRATLTEDGKHYLLNGTK-FWISNGGWADIMTVFA 237

  Fly   248 QTQQPNVPGVLGRGTTIFLVDSQQEGVRLGEKHATFGCRKAEIRRVHFEGVKLGEDQVVGLPHDG 312
            :|:..:..|......|.|:|:....||..|:.....|.|.:....:.||..|:..:.|:|...||
Zfish   238 RTEVVDKDGQKKDKITAFIVERAFGGVTSGKPEDKLGIRGSNTTEITFEDTKVPIENVIGEVGDG 302

  Fly   313 NRYSEQLVRSSRLRGSLVGLSLAKKLLNELAQYTVNTTQCGVQLQDLELTRIHMSRAMCSVYAME 377
            .:.:..::.:.|......|..:.|||:...|:|.....|...:|.:..:.:...:....:||.||
Zfish   303 FKVAMNILNNGRFSMGGAGAGVVKKLIELSAEYAGTRKQFNRRLSEFGMIQDKFATMALNVYVME 367

  Fly   378 SMLYLTAGLLDEFRAQDVTLESAITKYFTLRQVYAIASQNLGVVGPKSLLSGETTELGLRDAAQL 442
            ||.|||||::|.....|.:||:|:.|.|:....:...|:.|.|:|..........|..|||...|
Zfish   368 SMAYLTAGMMDRPGLPDCSLEAAMVKVFSSEGTWICVSEALQVLGGLGFTKNYPYERYLRDCRIL 432

  Fly   443 CTQGESLDTLGMFIALTGLQHAGQAMNTGVRKSRNPLFNPGHIF---GKFLDNNSIDNPKTKMQL 504
            .....:.:.|.|::||||:||||:.:...:::.:..  |.|.:|   ||.:        |..:|.
Zfish   433 QIFEGTNEILRMYVALTGMQHAGKILTGKIKEMKKG--NLGVVFEILGKKI--------KDTVQT 487

  Fly   505 SEH--------VHPSLEAAAQCIELSVARLQMAVELMFTKHGNAVVERQSEMQRLAEVGTLIYAM 561
            ::.        |||||..:|:..|.:.|.....||.:..::|..:|:.|..::::|:|...:|||
Zfish   488 ADFGLTGKDGVVHPSLTESAKMFEQNAACFGSTVEGLLYRYGKTIVDEQLLLKKVADVLINLYAM 552

  Fly   562 WASVARASRSYCIGLPLADHELLTATAICSEGRDRVRTLCTEIYGGHFVNNDNNLVRLSKQVAKS 626
            .|.::|:|||..|||...|||:|.....|.:...:...:.:::......|:|.|:.::::.|...
Zfish   553 TAVLSRSSRSISIGLRNHDHEVLLTNTFCKDAHFKNNYMLSQLQRYSPENDDANIKKIAQDVLAK 617

  Fly   627 KGYFAVHPLTFNF 639
            :.|...|||...|
Zfish   618 RAYICSHPLERTF 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Egm	NP_610687.1	ACAD	92..457	CDD:173838	103/380 (27%)
Egm	NP_610687.1	CaiA	122..439	CDD:224871	91/323 (28%)
acad9	NP_001038772.1	CaiA	75..447	CDD:224871	102/377 (27%)
acad9	NP_001038772.1	VLCAD	48..455	CDD:173850	120/411 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D163462at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820