DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Egm and ACOX1

DIOPT Version :9

Sequence 1:	NP_610687.1	Gene:	Egm / 36242	FlyBaseID:	FBgn0086712	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_004026.2	Gene:	ACOX1 / 51	HGNCID:	119	Length:	660	Species:	Homo sapiens

Alignment Length:	682	Identity:	143/682 - (20%)
Similarity:	231/682 - (33%)	Gaps:	192/682 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRPNL------FSGASRLLTYSRNG---KLLTRGRSTKATSSSLDSQHQDA-ATTEGGRAE-SVE 54
            |.|:|      .|....|||:..:|   |...|........:..|.||:|. ..|...|.| :|.
Human     1 MNPDLRRERDSASFNPELLTHILDGSPEKTRRRREIENMILNDPDFQHEDLNFLTRSQRYEVAVR 65

  Fly    55 ESPEQQRKLPTREPLAKNFFIGVVD-KELLAYPEVIPRDEMAQLENSL---LPL----------K 105
            :|....:|:  ||       .|:.| .|::.:...:.|.....|:..|   ||.          :
Human    66 KSAIMVKKM--RE-------FGIADPDEIMWFKNFVHRGRPEPLDLHLGMFLPTLLHQATAEQQE 121

  Fly   106 NYFVEPRETEETSPETLRQLG----LYGLNVSTDYEGKGYGWSASLMASEPDSTDINVTLG---- 162
            .:|:.....|........::|    |.||..:..|:.:    :...:.:.|..|.|....|
Human   122 RFFMPAWNLEIIGTYAQTEMGHGTHLRGLETTATYDPE----TQEFILNSPTVTSIKWWPGGLGK 182

  Fly   163 LQTHRVVVDLLKEVGTPLQQQRYLQDLATGKLIGTEA----IYEISPPEEDYFNTTAELFPEYGK 223
            ...|.:|:               .|.:..||..|..|    |.||...:.....|..::.|::|.
Human   183 TSNHAIVL---------------AQLITKGKCYGLHAFIVPIREIGTHKPLPGITVGDIGPKFGY 232

  Fly   224 WQL-NGEKSFVICTPGERQLFLVLAQ-----TQQPNVPGVLGRGTTI----FLVDSQQEGVRLGE 278
            .:: ||.............:.:..||     |....:...|..||.:    |||.   |..|...
Human   233 DEIDNGYLKMDNHRIPRENMLMKYAQVKPDGTYVKPLSNKLTYGTMVFVRSFLVG---EAARALS 294

  Fly   279 KHATFGCRKAEIRRVHFEGVKLGEDQVVGLPHDGNRYSEQLVRSSRLRGSLVGLSLAKKLLNELA 343
            |..|...|.:.:|  |...:|.||.:...|.....:|.         ...|:..:.|.:.:....
Human   295 KACTIAIRYSAVR--HQSEIKPGEPEPQILDFQTQQYK---------LFPLLATAYAFQFVGAYM 348

  Fly   344 QYTVNTTQCGVQLQDL-ELTRIHMSRAMCSVYAMESMLYLTAGLLDEFRAQDVTLESAITKYFTL 407
            :.|.:....|:...|| ||..:|.               |||||      :..|..:|.|.....
Human   349 KETYHRINEGIGQGDLSELPELHA---------------LTAGL------KAFTSWTANTGIEAC 392

  Fly   408 RQV-----YAIAS--QNLGV-VGPKSLLSGETTELGLRDAAQLCTQGESLDTLGMFIALTGLQHA 464
            |..     |:..|  .|:.| ..|.....||.|.:.|:.|..|.   :|.|.:          |:
Human   393 RMACGGHGYSHCSGLPNIYVNFTPSCTFEGENTVMMLQTARFLM---KSYDQV----------HS 444

  Fly   465 GQAMNTGVRKSRNPLFNPGHIFGKFLDNNSIDNPKTKMQLSE-HVHPSL------EAAAQCIELS 522
            |:.: .|:....|                  |.|..::|..: .|.|::      |:..:..:|.
Human   445 GKLV-CGMVSYLN------------------DLPSQRIQPQQVAVWPTMVDINSPESLTEAYKLR 490

  Fly   523 VARLQMAVELMFTKHGNAVVERQSEMQRLAEVGTLIYAMW----ASVARASRSYC--IGLPLADH 581
            .|||   ||:........|:.|:|:     ||.      |    ..:.|||.::|  :.:.|...
Human   491 AARL---VEIAAKNLQKEVIHRKSK-----EVA------WNLTSVDLVRASEAHCHYVVVKLFSE 541

  Fly   582 ELLTATAICSEGRDR-----VRTLCT--EIYG 606
            :||..       :|:     :|:||.  .:||
Human   542 KLLKI-------QDKAIQAVLRSLCLLYSLYG 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Egm	NP_610687.1	ACAD	92..457	CDD:173838	82/408 (20%)
Egm	NP_610687.1	CaiA	122..439	CDD:224871	72/347 (21%)
ACOX1	NP_004026.2	AXO	3..637	CDD:173839	142/680 (21%)
ACOX1	NP_004026.2	PLN02443	5..651	CDD:178062	141/678 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900