DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Egm and acox1

DIOPT Version :9

Sequence 1:	NP_610687.1	Gene:	Egm / 36242	FlyBaseID:	FBgn0086712	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001005933.1	Gene:	acox1 / 449662	ZFINID:	ZDB-GENE-041010-219	Length:	660	Species:	Danio rerio

Alignment Length:	525	Identity:	101/525 - (19%)
Similarity:	170/525 - (32%)	Gaps:	174/525 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 EQQRKLPTREPLAKNF-FIGVVDKELLAYPEVI----------PRDEMAQLENSLLPLKNYFVEP 111
            ||::|.   .|||::| .:|...:..|.:...|          |..:...|.:|.:....::  |
Zfish   118 EQRKKW---IPLAESFHMLGTYAQTELGHGTHIRALETTATYDPSTQEFVLNSSTISSIKWW--P 177

  Fly   112 RETEETSPETLRQLGLYGLNVSTDYEGKGYGWSASLMASEPDSTDINVTLGLQTHR-----VVVD 171
            ....:||...:....||       .:||.:|..|.:       |.|..   ::||.     ||.|
Zfish   178 GGLGKTSNHAIVLAQLY-------TQGKCHGLHAFI-------TPIRC---MKTHMPLPGVVVGD 225

  Fly   172 LLKEVGTPLQQQRYLQDLATGKLIGTEAIYEISPPEEDYFNTTAELFPE------------YG-- 222
            :..:.|.......||:            :..:..|.|:.....|::.|:            ||
Zfish   226 IGPKFGFDEVDNGYLK------------LENVRIPRENMLMKYAQVEPDGTYVKPPSDKLTYGTM 278

  Fly   223 ---KWQLNGEKSFVI---CT---------------PGERQLFLVLAQTQQPNVPGVLGRGTTIFL 266
               :..:.||.:..:   ||               |||.:..::..||||..:..:|........
Zfish   279 VFIRSMIVGESARALSKSCTIAIRYSAVRHQSELRPGEPEPQILDYQTQQYKLFPLLATAYAFHF 343

  Fly   267 VDSQQE--------GVRLG------EKHATFGCRKA----------EIRRVHFEGVKLGEDQVVG 307
            |.....        .:.||      |.||.....||          |:.|:...|  .|..:...
Zfish   344 VGQYMNKTYHRISGDISLGDFSELPELHALSAGLKAFTTWAANTGIEVCRMSCGG--HGYSRCSS 406

  Fly   308 LP-----------HDGN---------RYSEQLVRSSRLRGSLVGL-SLAKKLLNELAQYTVNTTQ 351
            ||           ::|.         ||..:..:.:|....|.|: |...:..:.:..::|::..
Zfish   407 LPDIYVTFTPTCTYEGENTVMMLQTARYLVKSYKQARAGQQLTGIVSYLNESQSRIQPHSVSSRP 471

  Fly   352 CGVQLQDL-ELTRIHMSRA--MCSVYAMESMLYLTAG----------LLDEFRAQDVTLESAITK 403
            ..|.:.|| .|...:..||  :..|.|....|.|...          .:|..||.|......:.|
Zfish   472 TVVNINDLVSLVEAYKFRAAKLVEVAAKNLQLELQHSKSNEDAWNNTSIDLVRASDAHCHYVVVK 536

  Fly   404 YFTLRQVYAIASQNLGVVGPKSLLSGETTELGLRDAAQLCTQGESLDTLGMFIALTGL-QHAGQA 467
            .|..:         |..:|.|::.|                   .|.||.:..||.|: |::|..
Zfish   537 LFAAK---------LSEIGDKAVHS-------------------VLSTLALLYALHGVAQNSGDF 573

  Fly   468 MNTGV 472
            :..|:
Zfish   574 LKAGL 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Egm	NP_610687.1	ACAD	92..457	CDD:173838	84/462 (18%)
Egm	NP_610687.1	CaiA	122..439	CDD:224871	76/414 (18%)
acox1	NP_001005933.1	AXO	3..637	CDD:173839	101/525 (19%)
acox1	NP_001005933.1	PLN02443	5..656	CDD:178062	101/525 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900