DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Egm and Acad9

DIOPT Version :9

Sequence 1:	NP_610687.1	Gene:	Egm / 36242	FlyBaseID:	FBgn0086712	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_861433.2	Gene:	Acad9 / 294973	RGDID:	727973	Length:	625	Species:	Rattus norvegicus

Alignment Length:	640	Identity:	183/640 - (28%)
Similarity:	300/640 - (46%)	Gaps:	49/640 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LLTRGRSTKATSSSLDSQHQDAATTEGGRAESVEESPEQQRKLPTRE---PLAKNFFIG-VVDKE 81
            |.:||    ||::        ||.....|...|  ..|::|.|.|..   ..||..|:| :..|.
  Rat     6 LFSRG----ATAA--------AAAARASRVLRV--FTERRRTLHTSLQSCSFAKELFLGHIQQKG 56

  Fly    82 LLAYPEVIPRDEMAQLENSLLPLKNYFVEPRETEETSPE---------TLRQLGLYGLNVSTDYE 137
            :..:||| .::|::::...:.||:.:|.|..::.:...|         .|:.|||:|:.|..:|.
  Rat    57 VFPFPEV-SQEELSEINQFVGPLEKFFNEEVDSRKIDQEGKIPADTLAKLKSLGLFGIQVPEEYG 120

  Fly   138 GKGYGWSASLMASEPDSTDINVTLGLQTHRVVVDLLKE---VGTPLQQQRYLQDLATGKLIGTEA 199
            |.|...:......|..|.|.::|:.|..|:.:.  ||.   ||...|:.:||..|::|:.|....
  Rat   121 GLGLSNTMYARLGEIISMDASITVTLAAHQAIG--LKGIILVGNEEQKAKYLPKLSSGEHIAAFC 183

  Fly   200 IYE-ISPPEEDYFNTTAELFPEYGKWQLNGEKSFVICTPGERQLFLVLAQTQQPNVPGVLGRGTT 263
            :.| .|..:.....|.|.|..:...:.|||.|.: |...|...:|.|.|:|:..:..|.:....|
  Rat   184 LTEPASGSDAASIQTRATLSEDKKYFVLNGSKVW-ITNGGLANIFTVFAKTEVVDSDGSIKDKMT 247

  Fly   264 IFLVDSQQEGVRLGEKHATFGCRKAEIRRVHFEGVKLGEDQVVGLPHDGNRYSEQLVRSSRL-RG 327
            .|:|:....|:..|:.....|.|.:....||||..::..:.|:|....|.:.:..::.|.|. .|
  Rat   248 AFIVERDFGGITNGKPEDKLGIRGSNTCEVHFENTRVPVENVLGEVGGGFKVAMNILNSGRFSMG 312

  Fly   328 SLVGLSLAKKLLNELAQYTVNTTQCGVQLQDLELTRIHMSRAMCSVYAMESMLYLTAGLLDEFRA 392
            |.|. .:.|||:.:.|:|.....|....|.:..|.:...:......|.||||.|||:|:||:...
  Rat   313 SAVA-GMLKKLIEQTAEYACTRKQFNRNLSEFGLIQEKFALMAQKAYVMESMAYLTSGMLDQPGF 376

  Fly   393 QDVTLESAITKYFTLRQVYAIASQNLGVVGPKSLLSGETTELGLRDAAQLCTQGESLDTLGMFIA 457
            .|.::|:|:.|.|:....:...|:.|.::|....:.....|..||||..|.....:.:.|.:|||
  Rat   377 PDCSIEAAMVKVFSSEAAWQCVSEALQILGGSGYMKDYPYERMLRDARILLIFEGTNEILRLFIA 441

  Fly   458 LTGLQHAGQAMNTGVR--KSRNPLFNPGHIFGKFLDN--NSIDNPKTKMQLSEH---VHPSLEAA 515
            ||||||||:.:.:.::  ||.|.......|..|..|:  .::|     :.||.:   |||||..:
  Rat   442 LTGLQHAGRILTSRIKELKSGNVTTVMETIGRKLRDSLGRTVD-----LGLSSNIAVVHPSLGDS 501

  Fly   516 AQCIELSVARLQMAVELMFTKHGNAVVERQSEMQRLAEVGTLIYAMWASVARASRSYCIGLPLAD 580
            |..:|.:|......||.:..:.|..:||.|..::|:|.:...:|.|.|.::|||||..|||...|
  Rat   502 ANKLEENVHYFGRTVETLLLRFGKTIVEEQLVLKRVANILINLYGMTAVLSRASRSIRIGLKNHD 566

  Fly   581 HELLTATAICSEGRDRVRTLCTEIYGGHFVNNDNNLVRLSKQVAKSKGYFAVHPL 635
            ||:|.|...|.|...:.....:::......|.|..:.::|:|:.:.:.|...|||
  Rat   567 HEILLANMFCVEAYFQNLFSLSQLDKYAPENLDEQIKKVSQQILEKRAYICAHPL 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Egm	NP_610687.1	ACAD	92..457	CDD:173838	101/378 (27%)
Egm	NP_610687.1	CaiA	122..439	CDD:224871	90/321 (28%)
Acad9	NP_861433.2	VLCAD	42..449	CDD:173850	117/411 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D163462at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920