DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Egm and Acadvl

DIOPT Version :9

Sequence 1:	NP_610687.1	Gene:	Egm / 36242	FlyBaseID:	FBgn0086712	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_037023.1	Gene:	Acadvl / 25363	RGDID:	2014	Length:	655	Species:	Rattus norvegicus

Alignment Length:	664	Identity:	165/664 - (24%)
Similarity:	293/664 - (44%)	Gaps:	68/664 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GKLLTRGRSTKATSSSLDSQHQDAATTE---GGRAESVEESPE------QQRKLPTREPLAKNFF 74
            |:.|.|..:..:.|::|..|.:..:...   ....::|.|.||      ..|:.|.|.. :|:|.
  Rat    11 GRQLLRLGARSSRSAALQGQPRPTSAQRLYASEATQAVLEKPETLSSDASTREKPARAE-SKSFA 74

  Fly    75 IGVVDKEL-----LAYPEVIPRDEMAQLENSLLPLKNYFVEPRE---------TEETSPETLRQL 125
            :|:...:|     ..||.|:...:...|:..:.|:..:|.|..:         .||.:.:.|::|
  Rat    75 VGMFKGQLTTDQVFPYPSVLNEGQTQFLKELVGPVARFFEEVNDPAKNDSLEKVEEDTLQGLKEL 139

  Fly   126 GLYGLNVSTDYEGKG-----YGWSASLMASEPDSTDINVTLGLQTHRVVVDLLKEV---GTPLQQ 182
            |.:||.|.::..|.|     |...|.::...    |:.|::.|..|:.:.  .|.:   ||..|:
  Rat   140 GAFGLQVPSELGGLGLSNTQYARLAEIVGMH----DLGVSVTLGAHQSIG--FKGILLYGTKAQK 198

  Fly   183 QRYLQDLATGKLIGTEAIYEISPPEEDYFNTTAELFPE-YGK-WQLNGEKSFVICTPGERQLFLV 245
            ::||..:|:|:.:....:.|.| ...|..:..:...|. .|| :.|||.|.: |...|...:|.|
  Rat   199 EKYLPRVASGQALAAFCLTEPS-SGSDVASIRSSAVPSPCGKYYTLNGSKIW-ISNGGLADIFTV 261

  Fly   246 LAQTQ-QPNVPGVLGRGTTIFLVDSQQEGVRLGEKHATFGCRKAEIRRVHFEGVKLGEDQVVGLP 309
            .|:|. :....|.:....|.|:|:....||..|......|.:.:....|:|:|||:..:.|:|..
  Rat   262 FAKTPIKDAATGAVKEKITAFVVERSFGGVTHGLPEKKMGIKASNTSEVYFDGVKVPAENVLGEV 326

  Fly   310 HDGNRYSEQLVRSSR--LRGSLVGLSLAKKLLNELAQYTVNTTQCGVQLQDLELTRIHMSRAMCS 372
            .||.:.:..::.:.|  :..:|.|  ..|.::.:...:..|.||.|.::.:..:.:..::|....
  Rat   327 GDGFKVAVNILNNGRFGMAATLAG--TMKAIIAKAVDHATNRTQFGDKIHNFGVIQEKLARMAIL 389

  Fly   373 VYAMESMLYLTAGLLDE-FRAQDVTLESAITKYFTLRQVYAIASQNLGVVGPKSLLSGETTELGL 436
            .|..|||.|:.:..:|: |:  |..:|:||:|.|.....:.:..:.:.::|....:.....|..|
  Rat   390 QYVTESMAYMLSANMDQGFK--DFQIEAAISKIFGSEAAWKVTDECIQIMGGMGFMKEPGVERVL 452

  Fly   437 RDAAQLCTQGESLDTLGMFIALTGLQHAGQAMNTGVRKS-RNPLFNPGHIFG---KFLDNNSIDN 497
            ||.........:.|.|.:|:||.|....|:.: ||:..: :|||.|.|.:.|   |.|...:  .
  Rat   453 RDIRIFRIFEGTNDILRLFVALQGCMDKGKEL-TGLGNALKNPLGNVGLLIGEASKQLRRRT--G 514

  Fly   498 PKTKMQLSEHVHPSLEAAAQCIELSVARLQMAVELMFTKHGNAVVERQSEMQRLAEVGTLIYAMW 562
            ..:.:.||..|||.|..:.:....::.:....||....||...:|..|..:||||:....:|||.
  Rat   515 IGSGLSLSGIVHPELSRSGELAVQALEQFATVVEAKLMKHKKGIVNEQFLLQRLADGAIDLYAMV 579

  Fly   563 ASVARASRSYCIGLPLADHELLTATAICSEGRDRVRTLCTEIYGGHFVNND------NNLVRLSK 621
            ..::|||||...|.|.|.||.:...:.|.|...|:|.....:.     :|.      .|...:||
  Rat   580 VVLSRASRSLSEGYPTAQHEKMLCDSWCIEAATRIRENMASLQ-----SNPQQQELFRNFRSISK 639

  Fly   622 QVAKSKGYFAVHPL 635
            .:.::.|....:||
  Rat   640 AMVENGGLVTSNPL 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Egm	NP_610687.1	ACAD	92..457	CDD:173838	91/387 (24%)
Egm	NP_610687.1	CaiA	122..439	CDD:224871	81/330 (25%)
Acadvl	NP_037023.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..70		13/59 (22%)
		Catalytic. /evidence=ECO:0000250\|UniProtKB:P49748	41..482		108/453 (24%)
		VLCAD	72..481	CDD:173850	100/420 (24%)
		CaiA	100..473	CDD:224871	91/384 (24%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P49748	461..463		0/1 (0%)
		Membrane-anchoring. /evidence=ECO:0000250\|UniProtKB:P49748	483..516		10/35 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D163462at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820