DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Egm and Acox2

DIOPT Version :9

Sequence 1:	NP_610687.1	Gene:	Egm / 36242	FlyBaseID:	FBgn0086712	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_665713.2	Gene:	Acox2 / 252898	RGDID:	628684	Length:	681	Species:	Rattus norvegicus

Alignment Length:	564	Identity:	109/564 - (19%)
Similarity:	188/564 - (33%)	Gaps:	159/564 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 FVEPRETEETSPETLRQLGLYGLNV-STDYEGKGYGWSASLMASEPDSTDINVTLGLQTHRVVVD 171
            :::..|||.|..|..::..::...: ||.:.....|||.:........|.:.|..|:  |..:|.
  Rat   161 YLQGLETEATYDEARQEFVIHSPTMTSTKWWPGDLGWSVTHAVVLAQLTCLGVRHGM--HAFIVP 223

  Fly   172 LLKEVGTPLQQQRYLQDLATGKL---IGTEAI-------YEISPPEEDYFNTTAELFPEYGKWQL 226
            :     ..|:....|..:..|.:   :|.|.|       ..:..|.|:..:..||:.|: |.:|.
  Rat   224 I-----RSLEDHTPLPGITVGDIGPKMGLEHIDNGFLQLNHVRVPRENMLSRFAEVLPD-GTYQR 282

  Fly   227 NGEKSFVICTPGERQLFLVLAQTQQPNVPGVLGRG-----------TTIFLVDSQQEGVRLGEKH 280
            .|       ||....|.:::.:.|      :|.:|           .|.:.|...|..:|..:..
  Rat   283 LG-------TPQSNYLGMLVTRVQ------LLCKGILPSLQKACIIATRYSVIRHQSRLRPSDPE 334

  Fly   281 ATFGCRKAEIRRV----------HFEGVKLGEDQVVGLPHDGNRYSEQLVRSSRLRGSLVGLSLA 335
            |.....:.:.:::          ||....|.|     ..|  :.||..|.|...|...|..||..
  Rat   335 AKILEYQTQQQKLLPQLAVSYAFHFTATSLSE-----FFH--SSYSAILKRDFSLLPELHALSTG 392

  Fly   336 KKLLNELAQYTVNTTQ-----CG----VQLQDLELTRIHMSRAMCSVYAMESMLYLTAGLLDEFR 391
            .|.  ..|.:.....:     ||    .:|..|. |.:..:.|.|:.....::|||
  Rat   393 MKA--TFADFCAQGAEICRRACGGHGYSKLSGLP-TLVARATASCTYEGENTVLYL--------- 445

  Fly   392 AQDVTLESAITKYFTLRQVYAIASQNLGVVGPKSLLSGE---TTELGLRDAAQLCTQGESLD--- 450
                    .:.::  |.:.|..|..:.|....|.|....   .|:...|.:||........|
  Rat   446 --------QVARF--LMKSYLQAQASPGATPQKPLPQSVMYIATQRPARCSAQTAADFRCPDVYT 500

  Fly   451 TLGMFIALTGLQHAGQAMNTGVRKSRNPLFNPGHIFGKFLDNNSIDNPKTKMQLSEHVHPSLEAA 515
            |...:::...::.|.....|        |...|      :|.:...|..|.:.|.       .|.
  Rat   501 TAWAYVSTRLIRDAAHRTQT--------LMKSG------VDQHDAWNQTTVIHLQ-------AAK 544

  Fly   516 AQCIELSVARLQMAVELMFTKHGNAVVERQSEMQRLAEVGTLIYAM-----------------WA 563
            |.|..::|...:.|||.:         :::.|:||:.:....:||:                 .|
  Rat   545 AYCYFITVKNFKEAVEKL---------DKEPEIQRVLQRLCDLYALHGVLTNSGDFLHDGFLSGA 600

  Fly   564 SVARASRSYCIGLPL--------------ADHELLTATAICSEG 593
            .|..|..::...|||              :||.|.:|.. |.:|
  Rat   601 QVDMAREAFLDLLPLIRKDAILLTDAFDFSDHCLNSALG-CYDG 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Egm	NP_610687.1	ACAD	92..457	CDD:173838	77/395 (19%)
Egm	NP_610687.1	CaiA	122..439	CDD:224871	68/360 (19%)
Acox2	NP_665713.2	AXO	20..655	CDD:173839	109/564 (19%)
Acox2	NP_665713.2	Microbody targeting signal. /evidence=ECO:0000255	679..681
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900