DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Egm and Acadm

DIOPT Version :9

Sequence 1:NP_610687.1 Gene:Egm / 36242 FlyBaseID:FBgn0086712 Length:639 Species:Drosophila melanogaster
Sequence 2:NP_058682.2 Gene:Acadm / 24158 RGDID:2012 Length:421 Species:Rattus norvegicus


Alignment Length:454 Identity:101/454 - (22%)
Similarity:177/454 - (38%) Gaps:100/454 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 LTRGRSTKATSSSLD--SQH-QDAATTEGGRAESVEESPEQQRKLPTREPLAKNFFIGVVDKELL 83
            |.||.....:.|..:  :|| :.:...|.|...|.|.: |||::..|   :|:.|          
  Rat     5 LRRGYKVLRSVSHFECRAQHTKPSLKQEPGLGFSFELT-EQQKEFQT---IARKF---------- 55

  Fly    84 AYPEVIP----RDEMAQLENSL------LPLKNYFVEPRETEETSPETLRQLGLYGLNVSTDYEG 138
            |..|:||    .|:..:....|      |.|.|..:         ||:...|||...:.....|.
  Rat    56 AREEIIPVAPDYDKSGEYPFPLIKRAWELGLINTHI---------PESCGGLGLGTFDACLITEE 111

  Fly   139 KGYGWSASLMASEPDSTDINVTLGLQTHRVVVDLLKEVGTPLQQQRYLQDLATGKLIGTEAI--- 200
            ..||.:....|.|.:|      ||...  |::     .|...|:::||     |::  ||.:   
  Rat   112 LAYGCTGVQTAIEANS------LGQMP--VII-----AGNDQQKKKYL-----GRM--TEQLMMC 156

  Fly   201 -YEISPPE--EDYFNTTAELFPEYGKWQLNGEKSFVICTPGERQLFLVLAQTQ-QPNVPGVLGRG 261
             |.::.|.  .|......:...:..::.:||:|.: |...|:...:.||.::. .|.||.  .:.
  Rat   157 AYCVTEPSAGSDVAGIKTKAEKKGDEYVINGQKMW-ITNGGKANWYFVLTRSNPDPKVPA--SKA 218

  Fly   262 TTIFLVDSQQEGVRLGEKHATFGCRKAEIRRVHFEGVKLGEDQVVGLPHDGNRYSEQLVRSSRLR 326
            .|.|:|::...|:.:|:|....|.|.::.|.:.||.|::.::.|  |..:|..:...:....|.|
  Rat   219 FTGFIVEADTPGIHIGKKELNMGQRCSDTRGITFEDVRVPKENV--LIGEGAGFKIAMGAFDRTR 281

  Fly   327 GSLV--GLSLAKKLLNELAQYTVNTTQCGVQLQD--------------LELTRIHMSRAMCSVYA 375
            .::.  .:.||::.|:|..:|.::....|..|.:              :||.|:...||...|  
  Rat   282 PTVAAGAVGLAQRALDEATKYALDRKTFGKLLVEHQGVSFLLAEMAMKVELARLSYQRAAWEV-- 344

  Fly   376 MESMLYLTAGLLDEFRAQDVTLESAITKYFTLRQVYAIASQNLGVVGPKSLLSGETTELGLRDA 439
                        |..|..  |..::|.|.|.......:|:..:.:.|.....:....|..:|||
  Rat   345 ------------DSGRRN--TYFASIAKAFAGDIANQLATDAVQIFGGYGFNTEYPVEKLMRDA 394

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EgmNP_610687.1 ACAD 92..457 CDD:173838 81/377 (21%)
CaiA 122..439 CDD:224871 72/339 (21%)
AcadmNP_058682.2 CaiA 39..420 CDD:224871 92/420 (22%)
MCAD 41..418 CDD:173846 91/418 (22%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:P41367 278..281 1/2 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1960
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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