DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Egm and Acox1

DIOPT Version :9

Sequence 1:	NP_610687.1	Gene:	Egm / 36242	FlyBaseID:	FBgn0086712	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_001258827.1	Gene:	Acox1 / 11430	MGIID:	1330812	Length:	661	Species:	Mus musculus

Alignment Length:	451	Identity:	92/451 - (20%)
Similarity:	145/451 - (32%)	Gaps:	152/451 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SRLLTYSRNGKLLTRGRSTKATSSSLDSQHQDAATTEGGRAESVEESPEQQRKLPTREPLAKNF- 73
            |..|||..  .:..|.....:.:.||..     |.|...|..:|....|.:|..|  ||...:|
Mouse   270 SNKLTYGT--MVFVRSFLVGSAAQSLSK-----ACTIAIRYSAVRRQSEIKRSEP--EPQILDFQ 325

  Fly    74 -----------------FIGVVDKE-LLAYPEVIPRDEMAQLENSLLPLKNYFVEPRETEETSPE 120
                             |:|...|| .:...|.|.:.::::|                     ||
Mouse   326 TQQYKLFPLLATAYAFHFLGRYIKETYMRINESIGQGDLSEL---------------------PE 369

  Fly   121 TLRQLGLYGLNVSTDYE-------------GKGYGWSASL----MASEPDST--DINVTLGLQTH 166
             |..| ..||...|.:.             |.||..|:.:    :...|..|  ..|..:.|||.
Mouse   370 -LHAL-TAGLKAFTTWTANAGIEECRMACGGHGYSHSSGIPNIYVTFTPACTFEGENTVMMLQTA 432

  Fly   167 RVVVDLLKEVGTPLQQQRYLQDLATGKLIGTEAIY-------EISPPEEDYFNTTAEL-----FP 219
            |.::.:..:|             .:|||:|....|       .|.|.:...:.|..::     ..
Mouse   433 RFLMKIYDQV-------------QSGKLVGGMVSYLNDLPSQRIQPQQVAVWPTLVDINSLDSLT 484

  Fly   220 EYGKWQLNGEKSFVICTPGERQLFLVLAQTQQPNVPGVLGRGTTIFLVDSQQEGVRLGEKHATFG 284
            |  .::|...:...|....      :.||........|....|::.|       ||..|.|.
Mouse   485 E--AYKLRAARLVEIAAKN------LQAQVSHRKSKEVAWNLTSVDL-------VRASEAHC--- 531

  Fly   285 CRKAEIRRVHFEGVKLGEDQVVGLPHDGNRYSEQLVRSSRLRGSLVGLS------LAKKLLNELA 343
                     |:..||:..|:   ||...:|..:.::|:..|..||.|:|      |...::....
Mouse   532 ---------HYVTVKVFADK---LPKIQDRAVQAVLRNLCLLYSLYGISQKGGDFLEGNIITGAQ 584

  Fly   344 QYTVNTTQCGVQLQDLELTRIHMSRAMCSVYAMESMLYLTAGLLDEFRAQDVTLESAITKY 404
            ...||:       :.|||..:....|:              .|:|.|..:||||.|.:.:|
Mouse   585 MSQVNS-------RILELLTVTRPNAV--------------ALVDAFDFKDVTLGSVLGRY 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Egm	NP_610687.1	ACAD	92..457	CDD:173838	69/350 (20%)
Egm	NP_610687.1	CaiA	122..439	CDD:224871	66/320 (21%)
Acox1	NP_001258827.1	AXO	3..638	CDD:173839	92/451 (20%)
Acox1	NP_001258827.1	Microbody targeting signal	659..661
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900