DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Egm and Acadvl

DIOPT Version :9

Sequence 1:	NP_610687.1	Gene:	Egm / 36242	FlyBaseID:	FBgn0086712	Length:	639	Species:	Drosophila melanogaster
Sequence 2:	NP_059062.1	Gene:	Acadvl / 11370	MGIID:	895149	Length:	656	Species:	Mus musculus

Alignment Length:	690	Identity:	170/690 - (24%)
Similarity:	297/690 - (43%)	Gaps:	96/690 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRPNLFSGASRLLTYSRNGKLLTRGR----------STKATSSSLDSQH---QDAATTE-GGRAE 51
            |.|::.....||...|.....:.:|:          :.:||.:.||...   .||:|.| ..|||
Mouse     6 MTPSVGRQLLRLGARSSRSTTVLQGQPRPISAQRLYAREATQAVLDKPETLSSDASTREKPARAE 70

  Fly    52 SVEESPEQQRKLPTREPLAKNFFIGVVDKEL-----LAYPEVIPRDEMAQLENSLLPLKNYFVEP 111
            |                  |:|.:|:...:|     ..||.|:..::...|:..:.|:..:|.|.
Mouse    71 S------------------KSFAVGMFKGQLTIDQVFPYPSVLSEEQAQFLKELVGPVARFFEEV 117

  Fly   112 RE---------TEETSPETLRQLGLYGLNVSTDYEGKG-----YGWSASLMASEPDSTDINVTLG 162
            .:         .|:.:.:.|::||.:||.|.::..|.|     |...|.::...    |:.|::.
Mouse   118 NDPAKNDALEKVEDDTLQGLKELGAFGLQVPSELGGLGLSNTQYARLAEIVGMH----DLGVSVT 178

  Fly   163 LQTHRVVVDLLKEV---GTPLQQQRYLQDLATGKLIGTEAIYEISPPEEDYFNTTAELFPE-YGK 223
            |..|:.:.  .|.:   ||..|:::||..:|:|:.:....:.|.| ...|..:..:...|. .||
Mouse   179 LGAHQSIG--FKGILLYGTKAQREKYLPRVASGQALAAFCLTEPS-SGSDVASIRSSAIPSPCGK 240

  Fly   224 -WQLNGEKSFVICTPGERQLFLVLAQTQ-QPNVPGVLGRGTTIFLVDSQQEGVRLGEKHATFGCR 286
             :.|||.|.: |...|...:|.|.|:|. :....|.:....|.|:|:....||..|......|.:
Mouse   241 YYTLNGSKIW-ISNGGLADIFTVFAKTPIKDAATGAVKEKITAFVVERSFGGVTHGLPEKKMGIK 304

  Fly   287 KAEIRRVHFEGVKLGEDQVVGLPHDGNRYSEQLVRSSR--LRGSLVGLSLAKKLLNELAQYTVNT 349
            .:....|:|:|||:..:.|:|...||.:.:..::.:.|  :..:|.|  ..|.|:.:...:..|.
Mouse   305 ASNTSEVYFDGVKVPSENVLGEVGDGFKVAVNILNNGRFGMAATLAG--TMKSLIAKAVDHATNR 367

  Fly   350 TQCGVQLQDLELTRIHMSRAMCSVYAMESMLYLTAGLLDE-FRAQDVTLESAITKYFTLRQVYAI 413
            ||.|.::.:..:.:..::|.....|..|||.|:.:..:|: |:  |..:|:||:|.|.....:.:
Mouse   368 TQFGDKIHNFGVIQEKLARMAILQYVTESMAYMLSANMDQGFK--DFQIEAAISKIFCSEAAWKV 430

  Fly   414 ASQNLGVVGPKSLLSGETTELGLRDAAQLCTQGESLDTLGMFIALTGLQHAGQAMNTGVRKS-RN 477
            |.:.:.::|....:.....|..|||.........:.|.|.:|:||.|....|:.: ||:..: :|
Mouse   431 ADECIQIMGGMGFMKEPGVERVLRDIRIFRIFEGANDILRLFVALQGCMDKGKEL-TGLGNALKN 494

  Fly   478 PLFNPGHIF---GKFLDNNSIDNPKTKMQLSEHVHPSLEAAAQCIELSVARLQMAVELMFTKHGN 539
            |..|.|.:.   ||.|...:  ...:.:.||..|||.|..:.:....::.:....||....||..
Mouse   495 PFGNVGLLMGEAGKQLRRRT--GIGSGLSLSGIVHPELSRSGELAVQALDQFATVVEAKLVKHKK 557

  Fly   540 AVVERQSEMQRLAEVGTLIYAMWASVARASRSYCIGLPLADHELLTATAICSEGRDRVRTLCT-- 602
            .:|..|..:||||:....:|||...::|||||...|.|.|.||.:...:.|.|...|:|....
Mouse   558 GIVNEQFLLQRLADGAIDLYAMVVVLSRASRSLSEGYPTAQHEKMLCDSWCIEAATRIRENMASL 622

  Fly   603 -------EIYGGHFVNNDNNLVRLSKQVAKSKGYFAVHPL 635
                   |::        .|...:||.:.::.|....:||
Mouse   623 QSSPQHQELF--------RNFRSISKAMVENGGLVTGNPL 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Egm	NP_610687.1	ACAD	92..457	CDD:173838	92/387 (24%)
Egm	NP_610687.1	CaiA	122..439	CDD:224871	83/330 (25%)
Acadvl	NP_059062.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		6/26 (23%)
		Catalytic. /evidence=ECO:0000250\|UniProtKB:P49748	42..483		114/470 (24%)
		VLCAD	73..482	CDD:173850	101/420 (24%)
		CaiA	95..474	CDD:224871	92/390 (24%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P49748	462..464		0/1 (0%)
		Membrane-anchoring. /evidence=ECO:0000250\|UniProtKB:P49748	484..517		9/35 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D163462at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820