DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tou and KAT2B

DIOPT Version :9

Sequence 1:NP_001097270.1 Gene:tou / 36241 FlyBaseID:FBgn0033636 Length:3131 Species:Drosophila melanogaster
Sequence 2:NP_003875.3 Gene:KAT2B / 8850 HGNCID:8638 Length:832 Species:Homo sapiens


Alignment Length:927 Identity:173/927 - (18%)
Similarity:311/927 - (33%) Gaps:296/927 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  2392 GSGAGNSLNPSSFNERTMALAAA-------AAASGPGNATGVANSAVVAGATPCESGSGEPNSGN 2449
            |:|||....|.:...:..||..|       |||:|...|.|.|.:...||......|.|...   
Human    13 GAGAGAGAGPGALPPQPAALPPAPPQGSPCAAAAGGSGACGPATAVAAAGTAEGPGGGGSAR--- 74

  Fly  2450 ASPASNCDSDRDEKVEQIPKGLVQWRDAVSRSHTTAQLAMALYVLESCVAWDKSIMKAYATKNKS 2514
                                  :..:.|..||...|:....|.|..:|.|.:......:...|.|
Human    75 ----------------------IAVKKAQLRSAPRAKKLEKLGVYSACKAEESCKCNGWKNPNPS 117

  Fly  2515 SKKKSSAKKQATPSKKQQQKKNKKEQQLTPNGKESKSKSAINK----------------PENQAP 2563
            .....:..:|...|..:..:..........:..|:.|:..:|:                .|..|.
Human   118 PTPPRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEEDAD 182

  Fly  2564 LS------IKINLKALAQNGQCLLKTKTPPILTKSPTASPSSHPNTSDSDSDFGKRTKKKSGGKR 2622
            ..      .|:..|::.|.|:.:::..    |.|.|   |...|:.....::|.:........|.
Human   183 TKQVYFYLFKLLRKSILQRGKPVVEGS----LEKKP---PFEKPSIEQGVNNFVQYKFSHLPAKE 240

  Fly  2623 RRSANN-----TNSSKYSNSLQNCQFCTSGENEDKLLLCDGCDKGYH---TYCFKPKM-DNIPDG 2678
            |::...     .|...|.:.....|......|:|    ..|..:.|.   .||..|:. |::|. 
Human   241 RQTIVELAKMFLNRINYWHLEAPSQRRLRSPNDD----ISGYKENYTRWLCYCNVPQFCDSLPR- 300

  Fly  2679 DWYCYECV---------------------------NKATNERKCIVCGGHRP------------- 2703
                ||..                           :|...|::.::. .|.|             
Human   301 ----YETTQVFGRTLLRSVFTVMRRQLLEQARQEKDKLPLEKRTLIL-THFPKFLSMLEEEVYSQ 360

  Fly  2704 -SPVGKMIYCDLCPRAYHADCYIPPLLKVPRGKWYCHGCISRAPPPKKRSAGGT----------- 2756
             ||:....:.....|.  :...|..::.               |||    ..||           
Human   361 NSPIWDQDFLSASSRT--SQLGIQTVIN---------------PPP----VAGTISYNSTSSSLE 404

  Fly  2757 ---SGSSSKS-RRDRDRESGGSAKRRSDNSKTPAMEHMQQQQMPLAGGDSHHHHHQQPPSLNSSH 2817
               :||||.: :.....|:....||:..:|..     :::.:.|...||.       |..|   .
Human   405 QPNAGSSSPACKASSGLEANPGEKRKMTDSHV-----LEEAKKPRVMGDI-------PMEL---I 454

  Fly  2818 DESMNSL--PAAPLSPAHSVVSATNYDDQ-------------HHANNSVD------------GSS 2855
            :|.|:::  |||.|.|..:.:||.:..|:             |...||::            |..
Human   455 NEVMSTITDPAAMLGPETNFLSAHSARDEAARLEERRGVIEFHVVGNSLNQKPNKKILMWLVGLQ 519

  Fly  2856 RFHAHLIP-------------PSNNGTAALLED--VPGGANVMPGVYP-------VYTPVAAG-- 2896
            ...:|.:|             |.:. |.||::|  |.||  :...::|       |:..|.:.  
Human   520 NVFSHQLPRMPKEYITRLVFDPKHK-TLALIKDGRVIGG--ICFRMFPSQGFTEIVFCAVTSNEQ 581

  Fly  2897 --NFSAGLIN-------QAPVQPAMPFANVVAMS-------PRAVTPTRTRTPTPTPAPTPPPPP 2945
              .:...|:|       :..:...:.:|:..|:.       .:.:...:|:...           
Human   582 VKGYGTHLMNHLKEYHIKHDILNFLTYADEYAIGYFKKQGFSKEIKIPKTKYVG----------- 635

  Fly  2946 PTPLLMQASPTATALHVNACQSPP----------------------QQQHAQLMTM-PSPPAIGV 2987
                .::....||.:   .|:..|                      :::.||:..: |     |:
Human   636 ----YIKDYEGATLM---GCELNPRIPYTEFSVIIKKQKEIIKKLIERKQAQIRKVYP-----GL 688

  Fly  2988 GTATNQMSPPPI-NIHAIQEA--KEKLKQEKKEKHATKKLMKELAVCKTLLGEMELHEDSWPFLL 3049
            ....:.:...|| :|..|:|.  |...|::.||.....:|...|   |::|.:::.|:.:|||:.
Human   689 SCFKDGVRQIPIESIPGIRETGWKPSGKEKSKEPRDPDQLYSTL---KSILQQVKSHQSAWPFME 750

  Fly  3050 PVNTKQFPTYRKIIKTPMDLSTIKKKLQDLSYKTREDFCVDVRQIFDNCEMFNEDDSPVGKAGHG 3114
            ||...:.|.|.::|:.||||.|:.::|::..|.:::.|..|::::|.||:.:|..:|...|..:.
Human   751 PVKRTEAPGYYEVIRFPMDLKTMSERLKNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCANI 815

  Fly  3115 MRKFFESRWGE--LTDK 3129
            :.|||.|:..|  |.||
Human   816 LEKFFFSKIKEAGLIDK 832

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
touNP_001097270.1 HAT_MBD 953..1027 CDD:238691
ZapA 1021..1127 CDD:294720
MAP7 1043..1198 CDD:283355
RILP-like 1085..>1179 CDD:304877
DDT 1255..1317 CDD:280886
WHIM1 1406..1455 CDD:292246
WHIM3 2190..2224 CDD:292248
PHD_BAZ2A_like 2640..2685 CDD:277020 11/48 (23%)
RanBP2-type Zn finger 2640..2659 CDD:275375 3/18 (17%)
RanBP2-type Zn finger 2680..2698 CDD:275376 4/44 (9%)
PHD 2695..2744 CDD:279022 6/62 (10%)
Bromo_BAZ2A_B_like 3027..3123 CDD:99935 31/95 (33%)
KAT2BNP_003875.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..54 13/40 (33%)
PCAF_N 75..325 CDD:368925 43/265 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 395..436 8/40 (20%)
COG5076 487..826 CDD:227408 71/367 (19%)
Acetyl-CoA binding. /evidence=ECO:0000269|PubMed:10393169 574..576 0/1 (0%)
Acetyl-CoA binding. /evidence=ECO:0000269|PubMed:10393169 581..587 0/5 (0%)
Acetyl-CoA binding. /evidence=ECO:0000269|PubMed:10393169 612..615 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 706..725 6/18 (33%)
Bromo_gcn5_like 727..826 CDD:99941 32/101 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5076
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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