DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tou and RSC4

DIOPT Version :9

Sequence 1:	NP_001097270.1	Gene:	tou / 36241	FlyBaseID:	FBgn0033636	Length:	3131	Species:	Drosophila melanogaster
Sequence 2:	NP_012933.4	Gene:	RSC4 / 853877	SGDID:	S000001716	Length:	625	Species:	Saccharomyces cerevisiae

Alignment Length:	663	Identity:	125/663 - (18%)
Similarity:	222/663 - (33%)	Gaps:	199/663 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1111 ELKNQQAVEERKKRQEELDR-----LKQEELLKK--QQEKE------KRRQEAILAKEQELQKQK 1162
            :::...::.|.|.|..|.:.     |...|||.|  |...|      |...:.::..|.|:.|.|
Yeast    95 KIQQPMSINEIKSRDYEYEDGPSNFLLDVELLTKNCQAYNEYDSLIVKNSMQVVMLIEFEVLKAK 159

  Fly  1163 EM----LLAAEMERERRRQHMSLIRMLELRRKFED-REKKKHQLVL---------DRLLLRE--R 1211
            .:    |:.:|::          .::|....|..| .|||.:|.:|         |::.|.|  .
Yeast   160 NLKRNYLINSEVK----------AKLLHYLNKLVDATEKKINQALLGASSPKNLDDKVKLSEPFM 214

  Fly  1212 RMAERKRDAEILQLIRRPNEDSEMPQELVIPELDRIAGNRLPGQAMADLLMVFEFLHNFGE---- 1272
            .:.::....|..:::..|...|.:.|.|.|.:..:|.      ..:.|:|:||:..|.|.:
Yeast   215 ELVDKDELPEYYEIVHSPMALSIVKQNLEIGQYSKIY------DFIIDMLLVFQNAHIFNDPSAL 273

  Fly  1273 ------TLG------FDMESLPSLQNLHDALMSDSNADAEEELLSVMTHLLVCAIEDPGVPNPGR 1325
                  ||.      ...|..|.||:|::.    ...:.|.:......:|.:      |...|..
Yeast   274 IYKDATTLTNYFNYLIQKEFFPELQDLNER----GEINLEFDKFEFENYLAI------GGGGPAA 328

  Fly  1326 HTTLLGQSLRNADITNSNVSEILRIYLYATATGEVRQMHGITVDRERERRVPDHHQLDSDTTTHS 1390
            ...|...:|.|.....||..:::                               .|.|.| ..|.
Yeast   329 AGALAISALDNDIEPESNREDLI-------------------------------DQADYD-FNHF 361

  Fly  1391 HSVKNQEYYKLLHENDTWKLSQSLKDRPFVALNPTRKAQMLAHLCNDLLMNKAVLRQIDGSLETC 1455
            ..:.|.....||.|                                |.|:|....:::....||.
Yeast   362 EGLGNGYNRSLLTE--------------------------------DYLLNPNNFKKLIAKPETV 394

  Fly  1456 AQMRKEKYMTDMKVRKYKALHMRKARIEAYERAQAEREAAMQALMAQQKLDAERLKAEEEAKAAA 1520
            ....|.:..|...:.|..:|.....:|..|...:: .:..||:|..|..::.:..|..::....:
Yeast   395 QSEVKNERSTTSDIEKTNSLESEHLKIPKYNVIKS-MQKEMQSLSEQHTMEYKPYKLIQQIYIFS 458

  Fly  1521 AEEAAAAAGTDGEATK---GGSP-----------NGEKPEDGDQNEEGAAKEPQQQQQQPMEVDG 1571
            ::...:      :|||   |..|           ||   .:..|||...:     ...|||:. .
Yeast   459 SKNLYS------QATKPLLGSRPSCNQNWVEYIFNG---NELSQNENAFS-----FMLQPMQT-F 508

  Fly  1572 VVDEASLVSPAKTIIQTDNSLTPSKQDMPTPTYQINGS-STP--TTSGVTGGDMNVLLQAKKSGA 1633
            :..::.|.|..|   .|:..||.:|:.:.:.|..:|.: |.|  ..:.|.|.|....::....|.
Yeast   509 LTLQSHLTSSLK---DTETLLTINKEPVKSRTSNVNSNLSQPQQQENDVIGNDTKQDIENLTIGG 570

  Fly  1634 RNSINDEHHHDVSIIDDDLSDLDSEITNVEEDEDNRLSADELQKKLDKIVRASLNCKEALEKSTN 1698
            .|: ||       |:.:|    :.:..|:.|..|.|||        :.:......|::.:...|.
Yeast   571 GNN-ND-------IVGND----NDKRNNITEIFDIRLS--------EGLNHLMFRCEDKISHETE 615

  Fly  1699 QLRAACFGQDRFW 1711
            .:        .||
Yeast   616 FM--------NFW 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tou	NP_001097270.1	HAT_MBD	953..1027	CDD:238691
		ZapA	1021..1127	CDD:294720	3/15 (20%)
		MAP7	1043..1198	CDD:283355	23/104 (22%)
		RILP-like	1085..>1179	CDD:304877	18/84 (21%)
		DDT	1255..1317	CDD:280886	15/77 (19%)
		WHIM1	1406..1455	CDD:292246	4/48 (8%)
		WHIM3	2190..2224	CDD:292248
		PHD_BAZ2A_like	2640..2685	CDD:277020
		RanBP2-type Zn finger	2640..2659	CDD:275375
		RanBP2-type Zn finger	2680..2698	CDD:275376
		PHD	2695..2744	CDD:279022
		Bromo_BAZ2A_B_like	3027..3123	CDD:99935
RSC4	NP_012933.4	COG5076	40..423	CDD:227408	76/417 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900