Protein Alignment tou and ITC1

DIOPT Version :10

• Sequence 1: NP_001097270.1
• Gene: tou / 36241
• FlyBaseID: FBgn0033636
• Length: 3131
• Species: Drosophila melanogaster
• Sequence 2: NP_011382.1
• Gene: ITC1 / 852744
• SGDID: S000003101
• Length: 1264
• Species: Saccharomyces cerevisiae
• Alignment Length: 1292
• Identity: 235/1292 - (18%)
• Similarity: 428/1292 - (33%)
• Gaps: 420/1292 - (32%)

  Fly   922 HMETSTDSESVAAESGLSESESED-ANILNVAELRVPLELGWKRETVIRGLTKQGQIRGEVTYYA 985
            ::....||.:.::.|..|..:.:| ..|.:|....:| :..::|..||:     .:::...|...
Yeast   125 YLRKQKDSSTTSSNSQQSTPQPDDMVEINSVGNPGLP-QYQYQRRYVIK-----EKVQFNATINP 183

  Fly   986 PGSTTPLKSNGQVFAILEQQPSNLS---------RENFSFSARAIVGSF---LQPAP----PPYA 1034
            ......:.::.:...|.|...||.|         |:..:|:...|...|   ||.|.    .|:.
Yeast   184 ESREIVMPAHTKYMLIEEAASSNKSFIVDQGQIYRDRSTFTKHLIKCFFKITLQRASSKMGAPWC 248

  Fly  1035 NDGEYIRM------TDEDVAKRLEDLKVFTRQ--TLNVEQRIEIAKQQQAMRDAKKLQKEELARN 1091
            ...||:.|      ..:|:.|..||..|..|:  :.||... |..|.::..:.:.|......|.|
Yeast   249 VKPEYLAMYGLTMEWPKDMLKYKEDEPVVARRSNSANVSSP-ESEKNKRQSKSSGKSNTSNDASN 312

  Fly  1092 KEKARQ----------EKNSKLEQQRKDKELKNQQAVEERKKRQEELDRLKQEELLKKQQEKE-- 1144
            |::.::          |.||..|.::|.:.:.::...::|||...|....:..|.:......|
Yeast   313 KKETKKKRKPTEVNDSENNSSEEDKKKGQNVTSETHSKKRKKEANEEPNTENVESVPTPANAEPQ 377

  Fly  1145 ----------------------------KRRQEAILAKEQELQKQKE---MLLAA-----EMERE 1173
                                        ..:.|.|.....:|.:..:   .||.|     ....:
Yeast   378 AVTITSIMDDLALPYQHPPNIFPNLTYYNEKLECISLGSTKLSRPFDSFGKLLQAYQFLNTFGSK 442

  Fly  1174 RRRQHMSLIRML---------ELRRK-----FEDREKKKHQLVLDRLLLRERRMAERKRDAE--- 1221
            ....|.||.:.:         ||:.:     ...:..|:.::..:.|.::.:.....:.|:|
Yeast   443 ICLSHFSLDQFITSLKCTDPYELKGEVVLVNIRTQTSKEQEIENNGLPMKNKAETTTEEDSENPS 507

  Fly  1222 -------ILQLIRRPNEDSEMPQELVIPE------LDRIAGNRLPGQAMADLLMVFE-----FLH 1268
                   |..:|.:.|.| ::..::|..:      ||.|..|   |.|:  |:.||.     |::
Yeast   508 DWQRNSFIRDMIMKRNSD-KVEYKIVHDDPASDDILDNINHN---GSAL--LIEVFTALLRLFIN 566

  Fly  1269 NFGE----------------------------------TLGFDMESLPSLQNLHDALM------- 1292
            ..|:                                  ..|:.::....:.||.|.|.
Yeast   567 EEGDWSCIVVENWIIDDKGVLMERKDERGEGEAKQKRNAHGYFLQDKEKIDNLKDTLKENATEVQ 631

  Fly  1293 ------------SDSNADAEEE-----LLSVMTHLLVCAIEDPGVPNPGRHTTLLGQSLRNADIT 1340
                        |||.:|::.|     |...:.:..|..||                .|......
Yeast   632 KESDAKNETNSESDSKSDSDSEERDPKLEKCLNYRNVNWIE----------------RLTKRQFN 680

  Fly  1341 NSNVSEILRIYLYATATGEVRQ-----MHGITVDRERERRVPDHHQLDSDTTTHSHSVKNQEYYK 1400
            ||        |......|.:..     |:...:|...|:.:|             ..:...:..|
Yeast   681 NS--------YWLIILLGVLEDCRHLPMYTEFIDSFIEKIIP-------------KDISATQLPK 724

  Fly  1401 LLHENDTWKLSQSLKDRPFVALNPTRKAQMLAHLCNDLLMNKAVLRQIDGSLETCAQMRKEKYMT 1465
            .|..|...|||.|.|......|     ..:::|...|:   ||.   :|.|:|.|.|:|.|::
Yeast   725 QLWRNFCRKLSFSDKVNALWIL-----VDLVSHFSPDI---KAA---VDDSMELCGQIRSERF-- 776

  Fly  1466 DMKVRKYKALHMRKARIEAYERAQAEREAAMQALMAQQKLDAERLKAEEEAKAAAAEEAAAAAGT 1530
              ||       .|:.:.||  ...:..:..:||:  |:||:    |.:|...:|
Yeast   777 --KV-------ARELKTEA--AVLSNLQGDLQAI--QEKLN----KTDENTPSA----------- 813

  Fly  1531 DGEATKGGSPNGEKPEDGDQNEEG-----AAKEPQQQQQQPMEVDGVVDEASLVSPAKTIIQTD- 1589
            ||         .:|.:|.:.|.|.     ..|:.:..::|..:|..:..:.:.:.  ..:.:.|
Yeast   814 DG---------ADKKDDSESNSEPIDLIIIEKKQKLIEEQDKKVQALQSDKNFLD--NCLFENDL 867

  Fly  1590 NSLTPSKQD-------------MPTPTYQINGSSTP-TTSGVTGGDMNVLLQAKKSGARN---SI 1637
            ..|.|...|             :|.|.|....:.|| :.:.::.....:|:|..|:.:..   ::
Yeast   868 QRLKPLGLDRYGNRYFWLDHNGVPFPQYPAGMNETPKSNNSLSYHSGRLLIQGPKASSAKFFLNV 932

  Fly  1638 NDEHHHDVSII--DDDLSDLDSEITNVEE------------------DEDNR----LSADELQKK 1678
            :||...:...|  .:.:|:...|:..:.:                  |.::|    :....:|||
Yeast   933 SDEQLSNWQKIRNSEGISEATREVFGISKTSSGSYNYVENGIEVELLDSNDRVNPLIELTPIQKK 997

  Fly  1679 L--DKIVRASLN-----CKEALE------------------------------KSTNQLRAACFG 1706
            :  :...|..|:     |.:.||                              ||:..||.....
Yeast   998 IMDETPSRLLLSPDQWYCIDKLEDLSRIMDWLDNWGRKEHDLLRQIRPIMERIKSSLSLRDHALS 1062

  Fly  1707 QDRFWRRYWKLPKAGGIFIEALESAQNDICDYHEALEAMDDKKDANDEKENSENEKDVAAESSE- 1770
            ...|.:...||.|.    :|..|..:|         |...|..|.:|:....::|.||..::.|
Yeast  1063 LTAFTKNEEKLLKE----LENNEFTEN---------ELNVDSMDVDDKNSGVKSEVDVQVDAEEK 1114

  Fly  1771 QPMEVDESITKLEDGVPASDVGMPESNQQNAHQDEEDDDDDVTE-----INKVEPEIVDLGDDDD 1830
            :...:||.:..:.|.:...|......|..|..|:.||..|::.|     ||...|
Yeast  1115 REAVIDEKLEVIADELMKLDDSSKTRNVLNRIQELEDQRDELLEQKKSIINSQRP---------- 1169

  Fly  1831 DAAPPLPKIEPPRPEI----KVKSEMELMGPPPTTMISTKTDFEAEIKIPSMPGILMPPTLNNNN 1891
             .|..|.:.|..|.:|    ||..::|::    |.:::.: .|:|...:.:...:|......::.
Yeast  1170 -GARILARSERKRTKISRGNKVNKQIEIL----TDLVNYR-HFKAMEDVIAWKNVLANSIWGSSL 1228

  Fly  1892 TNNNNNNNGSDNCDKLETGLGLGQQQQNFSQSVIKTEDVKKEDDCIIVSTSSVDDTP 1948
            ..|.:.|..|                     .||:|.|.|.:|   ||..:|...||
Yeast  1229 RKNASGNKRS---------------------GVIETVDDKLKD---IVGQTSRTVTP 1261

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tou	NP_001097270.1	HAT_MBD	953..1027	CDD:238691	14/85 (16%)
		TPH	<1041..1228	CDD:464007	43/266 (16%)
		PTZ00121	<1045..1681	CDD:173412	143/832 (17%)
		DDT	1255..1317	CDD:460696	19/124 (15%)
		WSD	1700..>1726	CDD:464775	6/25 (24%)
		WSD	<2173..2222	CDD:464775
		PHD_BAZ2A_like	2640..2685	CDD:277020
		RanBP2-type Zn finger	2680..2698	CDD:275376
		PHD	2695..2741	CDD:214584
		Bromo_BAZ2A_B_like	3027..3123	CDD:99935
ITC1	NP_011382.1	WAC_Acf1_DNA_bd	24..124	CDD:463140
		DDT	423..483	CDD:214726	9/59 (15%)
		WSD	869..952	CDD:464775	15/82 (18%)