DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tou and SPT7

DIOPT Version :9

Sequence 1:	NP_001097270.1	Gene:	tou / 36241	FlyBaseID:	FBgn0033636	Length:	3131	Species:	Drosophila melanogaster
Sequence 2:	NP_009637.1	Gene:	SPT7 / 852373	SGDID:	S000000285	Length:	1332	Species:	Saccharomyces cerevisiae

Alignment Length:	1579	Identity:	307/1579 - (19%)
Similarity:	524/1579 - (33%)	Gaps:	519/1579 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   927 TDSESVAAESGLSESESED----------ANI-LNVAELRVPLELGWKRETVIRGLTKQGQIRGE 980
            |..:.|..|..||.|..||          .|| ||| |...|             ||::.:..|.
Yeast    36 TSQQLVVLEYLLSISSEEDKLKAWDYFLKGNIALNV-EKSFP-------------LTQEEEHHGA 86

  Fly   981 VTYYAPG--------STTPLKSNGQVFAILEQQPSNLSRENFSFSARAIVGSFLQPAPPPYANDG 1037
            |   :|.        |:..:|.|...     ...:::|.||.      :............||:.
Yeast    87 V---SPAVDTRSDDVSSQTIKDNNNT-----NTNTSISNENH------VENEIEDKGDNAIANED 137

  Fly  1038 EYIR-----MTDEDVAK-RLEDLK---VFTRQTLNVEQRIEIAKQQQA----------------- 1076
            .::.     ..:||:.| .|||||   ..||...|:..:|.....|.|
Yeast   138 NFVNNDESDNVEEDLFKLDLEDLKQQISGTRFIGNLSLKIRYVLWQCAIDYIYCDRNEFGDENDT 202

  Fly  1077 ---MRDAKKLQKEELARNKEKARQEKNSKL--------EQQRKDKELKNQQAVEERKKRQEELDR 1130
               :.|.::.::||:.:|::...:|..||.        |.:..|::..:.:.|::..|   .||.
Yeast   203 EYTLLDVEEKEEEEIGKNEKPQNKEGISKFAEDEDYDDEDENYDEDSTDVKNVDDPPK---NLDS 264

  Fly  1131 LKQEELLKKQQEKEKRRQEAILAKEQELQKQKEMLLAAEMERERRRQHM------SLIRMLELRR 1189
            :....:   :.:.|:|....|...::.|.|.|...:...|....:..|.      ::|:.|:|..
Yeast   265 ISSSNI---EIDDERRLVLNISISKETLSKLKTNNVEEIMGNWNKIYHSFEYDKETMIKRLKLEE 326

  Fly  1190 --KFEDREKKKHQLVLDRLLLRERRMAERKRDAEILQLIRRPNEDSEMPQELVIPELDRIA--GN 1250
              |..::.|||          |.|...|...|.:..:   ..|::.:..|:|..||....:  ||
Yeast   327 SDKMIEKGKKK----------RSRSDLEAATDEQDRE---NTNDEPDTNQKLPTPEGSTFSDTGN 378

  Fly  1251 RLPGQAMADLLMVFEFLHNFGETLGFDMESLPSLQNLHDALMSDSN----ADAEEELLSVMTHLL 1311
            :.|.|:..||            |:...:|:| ||::|..::....:    :|.|      :.||:
Yeast   379 KRPKQSNLDL------------TVNLGIENL-SLKHLLSSIQQKKSQLGISDYE------LKHLI 424

  Fly  1312 VCAIEDPGVPNPGRHTT--LLGQSLRNADITNSNVSEILRIYLYATATGEVRQMHGIT------V 1368
            :...:     |..:.|:  .:||.                 .||......|.::...|      :
Yeast   425 MDVRK-----NRSKWTSDERIGQE-----------------ELYEACEKVVLELRNYTEHSTPFL 467

  Fly  1369 DRERERRVPDHHQL---DSDTTTHSHSVKNQEYYKLLHEND----TWKLSQSLKDRP--FV---A 1421
            ::..:|..|::||:   ..|..|....:|:.:|.......|    .||...:....|  |:   |
Yeast   468 NKVSKREAPNYHQIIKKSMDLNTVLKKLKSFQYDSKQEFVDDIMLIWKNCLTYNSDPSHFLRGHA 532

  Fly  1422 LNPTRKA-QMLAHLCNDLLMNKAVLRQIDGSLETCAQMRKEKYMTDMKVRKYKALHMRKARIEAY 1485
            :...:|: |::..:.|..:.|:|.|               ||.:.||:..|            .|
Yeast   533 IAMQKKSLQLIRMIPNITIRNRADL---------------EKEIEDMEKDK------------DY 570

  Fly  1486 ERAQAEREA--AMQAL-MAQQKLDAERLKAEEEAKAAAAEEAAAAAGTDGEATKGGSPNGEKPED 1547
            |..:.|..|  ..:.| |....|..|..|..|:..:...::.|.   |:.:......|.|||.:|
Yeast   571 ELDEEEEVAGSGRKGLNMGAHMLAKENGKVSEKDSSKTVKDEAP---TNDDKLTSVIPEGEKEKD 632

  Fly  1548 G------------DQNEEGAAKEPQQQQQQPMEVDGVVDEASLVSPAKTIIQTDNSLTPSKQDMP 1600
            .            ::||   .||..:.::|.|     |:|:|         :|::|   ||
Yeast   633 KTASSTVTVHENVNKNE---IKENGKNEEQDM-----VEESS---------KTEDS---SK---- 673

  Fly  1601 TPTYQINGSSTPTTSGVTGGDMNVLLQAKKSGARNSINDEHHHDVSIIDDDLSDLDSEITNVEED 1665
                ..:.:...|..|:    .:...:.|::|.    |:|...|....|:|...:||:...:|:|
Yeast   674 ----DADAAKKDTEDGL----QDKTAENKEAGE----NNEEEEDDDDEDEDEDMVDSQSYLLEKD 726

  Fly  1666 EDNRLSADELQKKLDKIVRASLNCKEALEKSTNQLRAACFGQD--RFWRRYWKLPKAGGIFIEAL 1728
            :|.    |:|:..:.|.|.|.:..:..| |.|...:......|  .|.:...::.:...:|:|..
Yeast   727 DDR----DDLEISVWKTVTAKVRAEICL-KRTEYFKNGKLNSDSEAFLKNPQRMKRFDQLFLEYK 786

  Fly  1729 ESAQNDICDYHEALEAMDDKKDANDEKENSENEKDVAAESSEQPMEVDESITKLEDGVPASDVGM 1793
            |         .:|||:...|.:.|...:|...                 ::.|.||
Yeast   787 E---------QKALESYRQKIEQNSIMKNGFG-----------------TVLKQED--------- 816

  Fly  1794 PESNQQNAHQDEEDDDDDVTEINKVEPEIVDLGD----DDDDAAPPLPKIEPPRPEIKVKSEMEL 1854
              .:|...|.|...:.::..|   .:|..::|.|    .:.|.:..:|.|.......|...:||
Yeast   817 --DDQLQFHNDHSLNGNEAFE---KQPNDIELDDTRFLQEYDISNAIPDIVYEGVNTKTLDKME- 875

  Fly  1855 MGPPPTTMISTKTDFEAEIKIPSMPGILMPPTLNNNNTNNNNNNNGSDNCDKLETGLGLGQQQQN 1919
                           :|.:......||        |..:....|.......|:...:.|.||.::
Yeast   876 ---------------DASVDRMLQNGI--------NKQSRFLANKDLGLTPKMNQNITLIQQIRH 917

  Fly  1920 FSQSVIKTEDVKKEDDCIIVSTSSVDDTPKWFSIVRREVPLISELPAEEGGVVGQELQISYANQN 1984
            ....:                           |::|.   |.|.|.|          |.|.:|.|
Yeast   918 ICHKI---------------------------SLIRM---LQSPLSA----------QNSRSNPN 942

  Fly  1985 CSAQLQLQGHPWDLINNMQY-YSIPMDECKVD-TSKLGNECIFSLSGLDEKQMLAKVEEYKAHKV 2047
            .            .:||..| |:|..|...:| .|:|...     ...:.::::.|.......||
Yeast   943 A------------FLNNHIYNYTIIDDSLDIDPVSQLPTH-----DYKNNRELIWKFMHKNISKV 990

  Fly  2048 ESKNGLGSPHRHHETKDDEEQAKLKLDKEIDTEMETDADDLAGKEKFFRLRSDVPPDTGGGVSEG 2112
            ...||..:.|                ...|:...|...|.|:...|..:|..:.     ..::.|
Yeast   991 AMANGFETAH----------------PSAINMLTEIAGDYLSNLIKTLKLHHET-----NSLNRG 1034

  Fly  2113 TDVKPKIELRLDEALSQAYYHNIANMSLSSVQTYIPIDIPLPLSMTPDEHRLLEQVKLAGFPERV 2177
            |:|         |.|......|..|                    .||:        |..:.|..
Yeast  1035 TNV---------EMLQTTLLENGIN--------------------RPDD--------LFSYVESE 1062

  Fly  2178 HGVYVPRRQRYGWWQLDDEQKLRQLLKT-LNPS--GLRERELQENLQRF---------------- 2223
            .|....:.|       |.:|||...|:. |.|:  .|.||..::..|.|
Yeast  1063 FGKKTKKLQ-------DIKQKLESFLRALLRPTLQELSERNFEDESQSFFTGDFASELTGEDFFG 1120

  Fly  2224 ---LGLEQPLGVNYKLKSDIDFPEEFLMPD-KKGDWNPKV-AKRVELALIEQLESLEDKVASASM 2283
               ||||:..||   |.|.:  |.:.|... :..|...|| ||:::   .|:.:|:..|..:..|
Yeast  1121 FRELGLEKEFGV---LSSSV--PLQLLTTQFQTVDGETKVQAKKIQ---PEESDSIVYKKITKGM 1177

  Fly  2284 ----QLKNWQLP------------------NRVESELTLDSQED-----VTEEDFVSIIPMIRER 2321
                ...|..||                  :....:.::.|.||     :.|:.|||.....:.|
Yeast  1178 LDAGSFWNTLLPLLQKDYERSKAYIAKQSKSSANDKTSMTSTEDNSFALLEEDQFVSKKTATKAR 1242

  Fly  2322 IIDLEANIERRYLKPPLGS 2340
             :.....|...|.|.|:.|
Yeast  1243 -LPPTGKISTTYKKKPIAS 1260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tou	NP_001097270.1	HAT_MBD	953..1027	CDD:238691	13/81 (16%)
		ZapA	1021..1127	CDD:294720	27/142 (19%)
		MAP7	1043..1198	CDD:283355	40/194 (21%)
		RILP-like	1085..>1179	CDD:304877	19/101 (19%)
		DDT	1255..1317	CDD:280886	13/65 (20%)
		WHIM1	1406..1455	CDD:292246	12/58 (21%)
		WHIM3	2190..2224	CDD:292248	12/55 (22%)
		PHD_BAZ2A_like	2640..2685	CDD:277020
		RanBP2-type Zn finger	2640..2659	CDD:275375
		RanBP2-type Zn finger	2680..2698	CDD:275376
		PHD	2695..2744	CDD:279022
		Bromo_BAZ2A_B_like	3027..3123	CDD:99935
SPT7	NP_009637.1	COG5076	282..680	CDD:227408	101/509 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900