DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tou and BRD3

DIOPT Version :9

Sequence 1:	NP_001097270.1	Gene:	tou / 36241	FlyBaseID:	FBgn0033636	Length:	3131	Species:	Drosophila melanogaster
Sequence 2:	NP_031397.1	Gene:	BRD3 / 8019	HGNCID:	1104	Length:	726	Species:	Homo sapiens

Alignment Length:	295	Identity:	94/295 - (31%)
Similarity:	130/295 - (44%)	Gaps:	60/295 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  2872 LLEDVPGGANVMPGVYPVYTPVAAGNFSAGLINQA---PVQPAMPFANV---VAMSP-RAVTPTR 2929
            ||...|.|....|         |||..|||....|   .|.||.||.:|   |:.:| .|.||..
Human   147 LLPPAPKGKGRKP---------AAGAQSAGTQQVAAVSSVSPATPFQSVPPTVSQTPVIAATPVP 202

  Fly  2930 TRTPTPTPAPTP----PPPPPTPLLMQASPTATALHVNACQSPPQQQHAQL-----MTMPSPPAI 2985
            |.|...|..|.|    ||||.||::....||           ||..:...:     .|.|:..||
Human   203 TITANVTSVPVPPAAAPPPPATPIVPVVPPT-----------PPVVKKKGVKRKADTTTPTTSAI 256

  Fly  2986 GVGTATNQMSPPPINI--------------HAIQEAKEKLKQEKKEKHATK--KLMKELAVCKTL 3034
               ||:...||||::.              ..|:..|:.|:..:..:||.|  ||.:.|..|.::
Human   257 ---TASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLRYCDSI 318

  Fly  3035 LGEM--ELHED-SWPFLLPVNTK--QFPTYRKIIKTPMDLSTIKKKLQDLSYKTREDFCVDVRQI 3094
            |.||  :.|.. :|||..||:.:  :...|..|||.||||||:|:|:....|...:.|..|||.:
Human   319 LREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLM 383

  Fly  3095 FDNCEMFNEDDSPVGKAGHGMRKFFESRWGELTDK 3129
            |.||..:|..|..|......::..||.|:.::.|:
Human   384 FSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDE 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tou	NP_001097270.1	HAT_MBD	953..1027	CDD:238691
		ZapA	1021..1127	CDD:294720
		MAP7	1043..1198	CDD:283355
		RILP-like	1085..>1179	CDD:304877
		DDT	1255..1317	CDD:280886
		WHIM1	1406..1455	CDD:292246
		WHIM3	2190..2224	CDD:292248
		PHD_BAZ2A_like	2640..2685	CDD:277020
		RanBP2-type Zn finger	2640..2659	CDD:275375
		RanBP2-type Zn finger	2680..2698	CDD:275376
		PHD	2695..2744	CDD:279022
		Bromo_BAZ2A_B_like	3027..3123	CDD:99935	36/100 (36%)
BRD3	NP_031397.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		Bromo_Brdt_I_like	34..140	CDD:99929
		Acetylated histone H3 binding. /evidence=ECO:0000269\|PubMed:27105114	78..80
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..169		9/28 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	237..305		15/70 (21%)
		Bromo_Brdt_II_like	311..412	CDD:99930	36/100 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	421..462
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..575
		BET	571..635	CDD:293640
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	637..726
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900