DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tou and Chd5

DIOPT Version :9

Sequence 1:	NP_001097270.1	Gene:	tou / 36241	FlyBaseID:	FBgn0033636	Length:	3131	Species:	Drosophila melanogaster
Sequence 2:	XP_017449128.1	Gene:	Chd5 / 691589	RGDID:	1582725	Length:	2000	Species:	Rattus norvegicus

Alignment Length:	611	Identity:	125/611 - (20%)
Similarity:	197/611 - (32%)	Gaps:	205/611 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  2193 LDDEQKLRQLLKTLNPSGLRERELQENL--QRFLGLE--------QPLGVNYKLKSDIDFPEEFL 2247
            |..|::|.:|.       ..|.|.:|.:  :...|||        :|:.:..|.      |::..
  Rat     5 LGTEEELPRLF-------AEEMENEEEMSEEEDGGLEGFEDFFPAEPVSLPKKK------PKKLK 56

  Fly  2248 MPDKKGDWNPKVAKRVELALIEQLESLEDKVASASMQLKNWQLPNRVESELTLDSQEDVTEEDFV 2312
            ....||....|.....||:  |..|.||:|..|......    |.:.:.:...:.:|...:.
  Rat    57 ESKSKGKRKKKEGSNDELS--ENEEDLEEKSESEGSDYS----PTKKKKKKLKEKKEKKAKR--- 112

  Fly  2313 SIIPMIRERIIDLEANIERRYLKPP-----LGSQTG--DAHLAVIAQNQHTTTQTQNSASAAAYL 2370
                  ::|..|.|.| |...||.|     |.::.|  |........:.||.|
  Rat   113 ------KKRDEDEEDN-EDGGLKEPKSSGQLMAEWGLDDVDYLFSEDDYHTLT------------ 158

  Fly  2371 LQMQQQQQQQQLAQQQQQQQQGSGAGNSLNPSSFNERTMALAAAAAASGPGNATGVANSAVVAGA 2435
                                         |..:|::....|.|......|     ::....|.||
  Rat   159 -----------------------------NYKAFSQFLRPLIAKKNPKIP-----MSKMMTVLGA 189

  Fly  2436 TPCESGSGEPNSGNASPASNCDSDRDEKVEQIPKGLVQWRDAVSRSHTTAQLAMALYVLESCVAW 2500
            ...|..:..|..|:::.|:..                    ||:.:..|..:|..|.:....|..
  Rat   190 KWREFSANNPFKGSSAAAAAA--------------------AVAAAVETVTIAPPLAISPQQVPQ 234

  Fly  2501 DKSIMKAYATKNKSSKKKSSAKKQATPSKKQQQKKNKKEQQLTPNGKESKSKSAINKPENQAPLS 2565
            ...:.||   |.|..|...            .:||||       ..|:||.|.     ..:....
  Rat   235 PLPVRKA---KTKEGKGPG------------VRKKNK-------GAKDSKKKG-----RGKRVAG 272

  Fly  2566 IKINLKALAQNGQCLLKTKTPPILTKSPTASPSSHPNTSDSD--------------SDFGKRTKK 2616
            :|.....:::.              |..::|....|..||.|              :..||:.|
  Rat   273 LKFRFGGISKR--------------KKGSSSEEDEPEDSDLDNASIHSSSVRSECSAALGKKNK- 322

  Fly  2617 KSGGKRRRSANNTNSSKYSNSLQN-CQFCTSGENEDKLLLCDGCDKGYHTYCFKPKMDNIPDGDW 2680
                :||:.....:...|....|: |:.|..|   .:::|||.|.:.||..|..|:::..|:|.|
  Rat   323 ----RRRKKKRIDDGDGYETDHQDYCEVCQQG---GEIILCDTCPRAYHLVCLDPELEKAPEGKW 380

  Fly  2681 YCYECVN-------KATNERK---------------CIVCGGHRPSPVGKMIYCDLCPRAYHADC 2723
            .|..|..       |..:|.:               |.||     ...|:::.||.||.:||..|
  Rat   381 SCPHCEKEGIQWEPKDDDEEEEEGGCEEEEDDHMEFCRVC-----KDGGELLCCDACPSSYHLHC 440

  Fly  2724 YIPPLLKVPRGKWYCHGCISRAPPPK 2749
            ..|||.::|.|:|.|..|  ..||.|
  Rat   441 LNPPLPEIPNGEWLCPRC--TCPPLK 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tou	NP_001097270.1	HAT_MBD	953..1027	CDD:238691
		ZapA	1021..1127	CDD:294720
		MAP7	1043..1198	CDD:283355
		RILP-like	1085..>1179	CDD:304877
		DDT	1255..1317	CDD:280886
		WHIM1	1406..1455	CDD:292246
		WHIM3	2190..2224	CDD:292248	7/32 (22%)
		PHD_BAZ2A_like	2640..2685	CDD:277020	15/45 (33%)
		RanBP2-type Zn finger	2640..2659	CDD:275375	6/19 (32%)
		RanBP2-type Zn finger	2680..2698	CDD:275376	6/39 (15%)
		PHD	2695..2744	CDD:279022	19/48 (40%)
		Bromo_BAZ2A_B_like	3027..3123	CDD:99935
Chd5	XP_017449128.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0383
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900