DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tou and Pbrm1

DIOPT Version :9

Sequence 1:	NP_001097270.1	Gene:	tou / 36241	FlyBaseID:	FBgn0033636	Length:	3131	Species:	Drosophila melanogaster
Sequence 2:	NP_001074720.1	Gene:	Pbrm1 / 66923	MGIID:	1923998	Length:	1704	Species:	Mus musculus

Alignment Length:	2060	Identity:	359/2060 - (17%)
Similarity:	637/2060 - (30%)	Gaps:	737/2060 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1174 RRRQHMSLIRML-------ELRRKFEDREKKKHQLVLDRLLLRERRMAERKRDAEILQLIRRPNE 1231
            |:|:.:|.:..:       ||.....|.:.::.:|:.:..:    |..:|:...:..:::.:|.:
Mouse    33 RKRRRLSNLPTVDPIAVCHELYNTIRDYKDEQGRLLCELFI----RAPKRRNQPDYYEVVSQPID 93

  Fly  1232 DSEMPQELVIPELDRIAGNRLPGQAMADLLMVFEFLHNFGETLGFDMESLPSLQNLH----DALM 1292
            ..::.|:|.:.|.|.:  |.|    .||..::|.....:.:....:.::...|.:|:    :..:
Mouse    94 LMKIQQKLKMEEYDDV--NLL----TADFQLLFNNAKAYYKPDSPEYKAACKLWDLYLRTRNEFV 152

  Fly  1293 SDSNADAEEELLSVMTHLLVCAIEDPGVPNPGRHTTLLGQSLRNADITNSNVSEILRIYLYA--T 1355
            ....||.|::             ::.|..|.|   ||...|      :...:.|||...|.|  .
Mouse   153 QKGEADDEDD-------------DEDGQDNQG---TLADGS------SPGYLKEILEQLLEAIVV 195

  Fly  1356 ATGEVRQMHGITVDRERERRVPDHHQLDSDTTTHSHSVKNQEYYKLLHEN-DTWKLSQSLKDRPF 1419
            ||....::..     |..:::|.             .|:..:||.::.|. |...::|.:::..:
Mouse   196 ATNPSGRLIS-----ELFQKLPS-------------KVQYPDYYAIIKEPIDLKTIAQRIQNGSY 242

  Fly  1420 VALNPTRKAQMLAHLCNDLLMNKAVLRQIDGSLETCAQMRKEKYMTDMKVRKYKALHMRKARIEA 1484
            .:::...|.       .|||...|......||     |:.|:  ...:|    |..:|:||.||.
Mouse   243 KSIHAMAKD-------IDLLAKNAKTYNEPGS-----QVFKD--ANSIK----KIFYMKKAEIEH 289

  Fly  1485 YERAQAEREAAMQALMAQQKLDAERLKAEEEAKAAAAEEAAAAAG--TDGEATKGG--SPNGEKP 1545
            :|..::...     :.....|.|.||......|::..||....:.  .:..|.:||  |......
Mouse   290 HEMTKSSLR-----IRTASNLAAARLTGPSHNKSSLGEERNPTSKYYRNKRAVQGGRLSAITMAL 349

  Fly  1546 EDGDQNEEGAAKEPQQQQQQPMEVDGVVDEASLVSPAKTIIQTDNSL--------------TPSK 1596
            :.|.::||.||....:.::...|.:.:.....:.:|...:..|..|.              .|||
Mouse   350 QYGSESEEDAALAAARYEEGESEAESITSFMDVSNPFHQLYDTVRSCRNHQGQLIAEPFFHLPSK 414

  Fly  1597 QDMPTPTYQINGSSTPTTSGVTGGDMNVLLQAKKSGARNSINDEHHH---DVSII---------- 1648
            :..|....||.              |.:.||..::..:|...:...|   |::::
Mouse   415 KKYPDYYQQIK--------------MPISLQQIRTKLKNQEYETLDHLECDLNLMFENAKRYNVP 465

  Fly  1649 ------------------------DDDLSDLDSEITNVEEDEDN----------------RLSAD 1673
                                    .||:.|.||.|::...|..:                |||:.
Mouse   466 NSAIYKRVLKLQQVMQAKKKELARRDDIEDGDSMISSATSDTGSAKRKRNTHDSEMLGLRRLSSK 530

  Fly  1674 E-LQKKLDKIVRASLN-CKEALEKSTNQLRAACFGQDRFWRRYWKLPKAGGIFIEALESAQNDIC 1736
            : ::|:..||:   .| ..||.|..:.  |..|   |.|                .::.::.|..
Mouse   531 KNIRKQRMKIL---FNVVLEAREPGSG--RRLC---DLF----------------MVKPSKKDYP 571

  Fly  1737 DYHE-ALEAMDDKKDANDEKENSENEKDVAAESSEQPMEVDESITKLEDGVPASDVGMPESNQ-- 1798
            ||:: .||.||.|    ..:.|..|:|                        .|.:.||.|..:
Mouse   572 DYYKIILEPMDLK----IIEHNIRNDK------------------------YAGEEGMMEDMKLM 608

  Fly  1799 -QNA-HQDEED----DDDDVTE--INKVEPEIVDLGDDDDDAAPPL---------PKIE------ 1840
             :|| |.:||.    :|..:.|  :.....|:..|.||||.|:|.|         ||..
Mouse   609 FRNARHYNEEGSQVYNDAHILEKLLKDKRKELGPLPDDDDMASPKLKLSRKSGVSPKKSKYMTPM 673

  Fly  1841 -----------------------------PPRPE-----IKVKSEMELMGPPPTTMISTKTDFEA 1871
                                         |.|.|     :.:|..|::.......|.:...|.::
Mouse   674 QQKLNEVYEAVKNYTDKRGRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDS 738

  Fly  1872 EIKIPSMPGILMPPTLNNNNTNNNNNN--------------------NGSDNCDKLETGLGLGQQ 1916
            .::    ..::|   .||..|.|...:                    .|.::.......|.:.:.
Mouse   739 MVE----DFVMM---FNNACTYNEPESLIYKDALVLHKVLLETRRDLEGDEDSHVPNVTLLIQEL 796

  Fly  1917 QQNFSQSVIKTEDVKKEDDCI--------IVSTSSVDDTPKWFSIVRREVPLISELPAEEGGVVG 1973
            ..|...||:..:|  .|..|.        .|..:|.:..|..|.|:|:.|
Mouse   797 IHNLFVSVMSHQD--DEGRCYSDSLAEIPAVDPNSPNKPPLTFDIIRKNV--------------- 844

  Fly  1974 QELQISYANQNCSAQLQL-QGHPWDLINNMQYYSIPMDECKVDTSKLGNECIFSLSGLDEKQMLA 2037
                    ..|...:|.| |.|.::::...:..:....|...|..:|             :|...
Mouse   845 --------ESNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVEL-------------QQFFI 888

  Fly  2038 KVEEYKAHKVESKNG--LGSPHRHHETK----DDEEQAKLKLDKEIDTEMETDADDLAGKEKFFR 2096
            ::.:...     |||  |.||...:.||    |.|::.|.||.|||      :.|.|..:|:  :
Mouse   889 RIRDELC-----KNGEILLSPALSYTTKHLHNDVEKEKKEKLPKEI------EEDKLKREEE--K 940

  Fly  2097 LRSDVPPDTGG--GVSEGTDVKPKIELRLDEALSQAYYHNIA-NMSLSSVQTYIPIDIPLPLSMT 2158
            ..::...|:.|  |:|               .|.:.|..:.: ..|:..|..|:.:: |...::.
Mouse   941 REAEKSEDSSGTTGLS---------------GLHRTYSQDCSFKNSMYHVGDYVYVE-PAEANLQ 989

  Fly  2159 PDEHRLLEQVKLAGFPERVHGVYVPR--------RQRYGWWQLDDEQKLRQLLKTLNPSGLRERE 2215
            |                  |.|.:.|        :..||.|.....:......:..    |.:..
Mouse   990 P------------------HIVCIERLWEDSAGEKWLYGCWFYRPNETFHLATRKF----LEKEV 1032

  Fly  2216 LQENLQRFLGLEQPLGVNYKLKSDIDFPEEF--LMPDKKGDWNPKVAKRVELALIEQLESLEDKV 2278
            .:.:....:.:.:.||     |..:.|.:|:  |.|:...|.:..|.           ||.....
Mouse  1033 FKSDYYNKVPVSKILG-----KCVVMFVKEYFKLCPENFRDEDVFVC-----------ESRYSAK 1081

  Fly  2279 ASASMQLKNWQLPNRVESELTLDSQEDVTEEDFVSIIPMIRERIIDLEANIERRYLKPPLGSQTG 2343
            ..:..::|.|.:|        :.|...|..:     :|:...|:..:.||.::           |
Mouse  1082 TKSFKKIKLWTMP--------ISSVRFVPRD-----VPLPVVRVASVFANADK-----------G 1122

  Fly  2344 DAHLAVIAQNQHTTTQTQNSASAAAYLLQMQQQQQQQQLAQQQQQQQQGSGAGNSLNPSSFNERT 2408
            |        ::..|..:.::.:...:.|:.:::....:::       .|....:......:|:..
Mouse  1123 D--------DEKNTDNSDDNRAEDNFNLEKEKEDVPVEMS-------NGEPGCHYFEQLRYNDMW 1172

  Fly  2409 MALAAAAAASGPGNATGVANSAVVAGATPCESGSGEPNSGNASPASNCDSD---------RDEKV 2464
            :.:         |:...:.:..:|           .|..|........|..         ..|:.
Mouse  1173 LKV---------GDCVFIKSHGLV-----------RPRVGRIEKVWVRDGAAYFYGPIFIHPEET 1217

  Fly  2465 EQIPKGLVQWRDA-VSRSHTTAQLAMALYVLESCVAW--------------DKSIMKAYATKNKS 2514
            |..|..:...::. :|....|..::.   :|..|...              :..|:...:..|:|
Mouse  1218 EHEPTKMFYKKEVFLSNLEETCPMSC---ILGKCAVLSFKDFLSCRPTEIPENDILLCESRYNES 1279

  Fly  2515 SKKKS----------SAK----------KQATPSKKQQQKKNKKEQQLTPN-------------- 2545
            .|:..          |||          |...|.|:......||.|.|...
Mouse  1280 DKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIIPQKEPSPLLEKKIQLLEAKFAELEGGDDDIEEM 1344

  Fly  2546 GKE-SKSKSAINKPENQAPLSIKINLKALAQNGQCLLKTKTPPILTKSPTASPSSHPNTSDSDSD 2609
            |:| |:...|.:.|:.|.||:.:::|                     .|...|.|.|.::
Mouse  1345 GEEDSEVIEAPSLPQLQTPLANELDL---------------------MPYTPPQSTPKSA----- 1383

  Fly  2610 FGKRTKKKSGGKRRRSANNTNSSKYSNSLQNCQFCTSGENEDKLLLCDGCDKGYHTYCFKPKMDN 2674
              |.:.||...||:     .|.|.|.......:.....::.|              |.| .::..
Mouse  1384 --KGSAKKESSKRK-----INMSGYILFSSEMRAVIKAQHPD--------------YSF-GELSR 1426

  Fly  2675 IPDGDWYCYECVNKAT-NERKCIVCGGHRPSPVGKMIYCDLCPRAYHADCYIPPLLKVPRGKWYC 2738
            :...:|...|...||. .||...|..........:.......|||           ..|.|
Mouse  1427 LVGTEWRNLETAKKAEYEERAAKVAEQQERERAAQQQQPSASPRA-----------GTPVG---- 1476

  Fly  2739 HGCISRAPPPKKRSAGGTSGSSSKSRRDRDRESGGSAKRRSDNSKTPAMEHMQQQQMPLAGGDSH 2803
             ..:...|||                                   || |..:.||..|:||....
Mouse  1477 -ALMGVVPPP-----------------------------------TP-MGMLNQQLTPVAGMMGG 1504

  Fly  2804 HHHHQQPPSLNSSHDESMNSLPAAPL-SPAHSVVSATNYDDQHHANNSVDGSSRFHAHLIPPSNN 2867
            :     ||.|             .|| .|...:||..:....|.....        .|.:||.
Mouse  1505 Y-----PPGL-------------PPLQGPVDGLVSMGSMQPLHPGGPP--------PHHLPPG-- 1541

  Fly  2868 GTAALLEDVPGGANVMPGVYPVYTPVAAGNFSAGLINQ-------APVQPAMPFANVVAMSPRAV 2925
                    |||    :||:.|           .|::||       .|.....|:...|.:    :
Mouse  1542 --------VPG----LPGIPP-----------PGVMNQGVAPMVGTPAPGGSPYGQQVGV----L 1579

  Fly  2926 TPTRTRTPTPTPAPTPPPP-----PPTPLLMQASP-TATALHVNA 2964
            .|...:.|.|.|.|.|..|     |.||:.:...| |...||..|
Mouse  1580 GPPGQQAPPPYPGPHPAGPPVIQQPTTPMFVAPPPKTQRLLHSEA 1624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tou	NP_001097270.1	HAT_MBD	953..1027	CDD:238691
		ZapA	1021..1127	CDD:294720
		MAP7	1043..1198	CDD:283355	6/30 (20%)
		RILP-like	1085..>1179	CDD:304877	2/4 (50%)
		DDT	1255..1317	CDD:280886	8/65 (12%)
		WHIM1	1406..1455	CDD:292246	9/48 (19%)
		WHIM3	2190..2224	CDD:292248	2/33 (6%)
		PHD_BAZ2A_like	2640..2685	CDD:277020	4/44 (9%)
		RanBP2-type Zn finger	2640..2659	CDD:275375	1/18 (6%)
		RanBP2-type Zn finger	2680..2698	CDD:275376	6/18 (33%)
		PHD	2695..2744	CDD:279022	6/48 (13%)
		Bromo_BAZ2A_B_like	3027..3123	CDD:99935
Pbrm1	NP_001074720.1	Bromo_polybromo_I	44..156	CDD:99954	18/121 (15%)
		Bromo_polybromo_II	182..284	CDD:99948	27/137 (20%)
		Bromo_polybromo_III	383..484	CDD:99951	15/114 (13%)
		Bromo_polybromo_IV	534..637	CDD:99949	33/154 (21%)
		Bromo_polybromo_V	673..777	CDD:99946	12/110 (11%)
		Bromo_polybromo_VI	790..897	CDD:99956	23/149 (15%)
		BAH_polybromo	972..1089	CDD:240068	22/155 (14%)
		BAH_polybromo	1170..1288	CDD:240068	16/140 (11%)
		HMG-box	1395..1459	CDD:238037	13/83 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900