DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tou and phf21ab

DIOPT Version :9

Sequence 1:	NP_001097270.1	Gene:	tou / 36241	FlyBaseID:	FBgn0033636	Length:	3131	Species:	Drosophila melanogaster
Sequence 2:	XP_021326289.1	Gene:	phf21ab / 565544	ZFINID:	ZDB-GENE-030131-6456	Length:	892	Species:	Danio rerio

Alignment Length:	892	Identity:	172/892 - (19%)
Similarity:	301/892 - (33%)	Gaps:	244/892 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   452 STGVSPSATVTSSPHHSSQQQQQMGGNSSTSGSGKSSSKDYMMGTG---SEHPSLLGVRLPPDTE 513
            :..|||:.|              ..|.||.|..|:::...:::...   |..|.|...||....:
Zfish     6 TASVSPTVT--------------WRGCSSESSDGRANDPAHLLHCHKFLSSGPLLFSDRLKVSRD 56

  Fly   514 IIKYTSSIVGPKIPGTTSRGRKKTISETEQQTTQQQQKQQHQAEQHLLQQQQQ------AQKELD 572
            .:.:                  :|.|..|.||.|:..|.:.|..|.|:.|.:|      .:|:|.
Zfish    57 SLFW------------------RTGSMMELQTLQEALKVEIQVHQKLVAQMKQDPQNADLKKQLH 103

  Fly   573 STKNAISSLLAFPGLSPAKRARLEMEYAAMAAAAQQQHQQAQQQHQAQQQLHGMLGAAGIPGMAG 637
            ..:..|::|        :::.:..:|........:|:.....|...|......:|..|..|....
Zfish   104 ELQAKITAL--------SEKQKKVVEQLRKELLVKQEPDLKPQTFAATTDGKTVLLTAACPASQP 160

  Fly   638 LVGLPGMSGNPLDQLSVS------------KASSSTAPTTSTSSSSA-------------GSNLL 677
            :.|.|...|.|...|:|:            ||::||.|.:..:..||             |:|..
Zfish   161 ISGPPHNQGAPQKTLTVTPVITAKTLPLVLKAATSTMPASMATQRSAVAMVTAINNPTRPGANSD 225

  Fly   678 NQSNSDRVEVI-KLPPTITSNGAYNLSSKGKEVHDLTTDMATNSGGVNLSLKSNAGSSALTPSGA 741
            :||....:::. |||...|..|. .:.||...|...||
Zfish   226 SQSTPINLQMASKLPNQDTDAGT-RIVSKNVIVVQATT--------------------------- 262

  Fly   742 VGSASNPITIDDFDAPLNLS--------MKPSDKSNSSSSNAAAGGSSSSSAAL--------ANL 790
              :::.||.:..|..|..|:        ::|...:..:...|.|......:|.|        ..|
Zfish   263 --TSAQPIKVPQFVPPPRLTPRPTFQPQVRPKPPTPINVPIAPAPPPPMVAAPLIQRPLMLTTKL 325

  Fly   791 ASDYQAASSGQ-------SGNSLQSLSSITAALGGTGGMPGGSISGSGGTSPAPAGAGSGATGGG 848
            .|.. .||:|.       :|....::...|..:.||..:.|..|      |||.....|......
Zfish   326 TSSL-PASAGPIHQVRIVNGQQCTTIDKTTTTVTGTTQLAGIVI------SPAQTLQISNLNSDL 383

  Fly   849 SGSGGSGGGSSSYKEGRPRN---LGRGVSKPKKNTVASLLAQSRAVGLKPMLATQQLLQQGADIE 910
            ......||......:..|.:   |....:|.|:......||...::|    |.|...|::
Zfish   384 KTVKPQGGPEQVVIKTPPSSSPPLPPPPAKVKREESPQKLAFMVSLG----LVTHDHLEE----- 439

  Fly   911 KIRLALSEANAHMETSTDSESVAAESGLSESESEDANILNVAELRVPLELGWKRETVIRGLTKQG 975
                 :.......:..|.:..|.:.:.......:.|    |..|..||..|.::
Zfish   440 -----IQSRRQERKRRTTANPVYSGAVFEPERKKSA----VTYLNTPLHQGTRK----------- 484

  Fly   976 QIRGEVTYYAPGSTTPLKSNGQVFAILEQQPSNLSRENFSFSA-----RAIVGSF-------LQP 1028
              ||....|:..:||...|:   .|:.|...:.|.....|..|     |...|.|       ..|
Zfish   485 --RGRPPKYSTTTTTTTSSS---TAVPELGCNPLLSPTSSLPASPAPERPDTGGFPLSVHPHSVP 544

  Fly  1029 APPPYANDGE-------YIRMTDE----DVAKRLEDLKVFTRQTLNVEQRIEIAKQQQAMRDAKK 1082
            .|.|.:.||:       ..|.:.:    |...|:..|........|:.:.:.|..:.|    .:.
Zfish   545 QPSPSSGDGDIHEDFCTVCRRSGQLLMCDTCSRVYHLDCLDPPLKNIPKGMWICPKCQ----DQI 605

  Fly  1083 LQKEE-------LA------RNKEKARQEKNSKLEQQRKDKELKNQQAVEERKKRQEELDRLKQE 1134
            |:|||       ||      ..|| |::|:..||.:...:.:|:.:| :|:|.|:
Zfish   606 LKKEEAIPWPGTLAIVHSYIAYKE-AKEEEKQKLMKWSAELKLEREQ-LEQRVKQ---------- 658

  Fly  1135 ELLKKQQEKEKRRQEAILAKEQELQKQKEMLLAAEMERERRRQHMSLIRMLELRRKFEDREKKKH 1199
              |.....|....:.:|||:::::|        |.:|:.:.     |:|:::   .|...:..:.
Zfish   659 --LSNSITKCMETKNSILARQKDMQ--------ASLEKVKH-----LVRLIQ---SFNFTQPMET 705

  Fly  1200 QLVLD-RLLLRERRMAERKRDAEILQLIRRPNEDS-EMPQELVIPEL 1244
            :.:.| :....|....:..:|...:.:...|.|.| ::|..:.:||:
Zfish   706 ETLKDSKQDCAESGSIKDSKDTTQVCVQESPTEPSVQVPAAVAVPEV 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tou	NP_001097270.1	HAT_MBD	953..1027	CDD:238691	18/85 (21%)
		ZapA	1021..1127	CDD:294720	31/136 (23%)
		MAP7	1043..1198	CDD:283355	34/171 (20%)
		RILP-like	1085..>1179	CDD:304877	24/106 (23%)
		DDT	1255..1317	CDD:280886
		WHIM1	1406..1455	CDD:292246
		WHIM3	2190..2224	CDD:292248
		PHD_BAZ2A_like	2640..2685	CDD:277020
		RanBP2-type Zn finger	2640..2659	CDD:275375
		RanBP2-type Zn finger	2680..2698	CDD:275376
		PHD	2695..2744	CDD:279022
		Bromo_BAZ2A_B_like	3027..3123	CDD:99935
phf21ab	XP_021326289.1	STAT_alpha	64..>125	CDD:307245	16/68 (24%)
phf21ab	XP_021326289.1	PHD_PHF21A	559..601	CDD:276998	6/41 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0383
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900