DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tou and PHF21A

DIOPT Version :9

Sequence 1:	NP_001097270.1	Gene:	tou / 36241	FlyBaseID:	FBgn0033636	Length:	3131	Species:	Drosophila melanogaster
Sequence 2:	XP_011518459.1	Gene:	PHF21A / 51317	HGNCID:	24156	Length:	688	Species:	Homo sapiens

Alignment Length:	893	Identity:	172/893 - (19%)
Similarity:	265/893 - (29%)	Gaps:	388/893 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly  2215 ELQENLQRFLGLEQPLGVNYKL----KSDIDFPEEFLMPDKKGDWNPKVAKRVELALIEQLESLE 2275
            ||| .||..|.:|  :.|:.||    |.|   |:.|.:.::..|            |.:||..|:
Human     2 ELQ-TLQEALKVE--IQVHQKLVAQMKQD---PQIFFLSNQNAD------------LKKQLHELQ 48

  Fly  2276 DKVASASMQLKNWQLPNRVESELTLDSQEDVTEEDFVSIIPMIRERIIDLEANIERRYLKPPLGS 2340
            .|:.:.|                  :.|:.|.|:        :|:.:|..:...::..::|
Human    49 AKITALS------------------EKQKRVVEQ--------LRKNLIVKQEQPDKFQIQP---- 83

  Fly  2341 QTGDAHLAVIAQNQHTTTQTQNSASAAAYLLQMQQQQQQQQLAQQQQ----QQQQGSGAGNSLNP 2401
                            ..|::|.       ||..|||..|||.||||    ..||.:.|..:|..
Human    84 ----------------LPQSENK-------LQTAQQQPLQQLQQQQQYHHHHAQQSAAASPNLTA 125

  Fly  2402 SSFNERTMALAA------------AAAASGPGNATGVANSAVVAGATPCESGSGEPNSGNASPAS 2454
            |   ::|:..|:            ||.|:.|.:..|...:..:..|.         ||..|..::
Human   126 S---QKTVTTASMITTKTLPLVLKAATATMPASVVGQRPTIAMVTAI---------NSQKAVLST 178

  Fly  2455 NCDSDRDEKVEQIPKGLVQWRDAVSRSHTTAQLAMALYVLESCVAWDKSIMKAYATKNKSSKKKS 2519
            :        |:..|..|      .:.|..|...|.|:.::                    :|...
Human   179 D--------VQNTPVNL------QTSSKVTGPGAEAVQIV--------------------AKNTV 209

  Fly  2520 SAKKQATPSKKQQQKKNKKEQQLTPNGK-----ESKSKSAINKPENQAP--------------LS 2565
            :.:.||||.:..:..:.....:|||...     ..|..:..|.|...||              :.
Human   210 TLQVQATPPQPIKVPQFIPPPRLTPRPNFLPQVRPKPVAQNNIPIAPAPPPMLAAPQLIQRPVML 274

  Fly  2566 IKINLKAL-----------AQNGQCLLKTKTPPI--LTKSPTASP-------------------- 2597
            .|.....|           ..|||.....||.|:  ||....|:|
Human   275 TKFTPTTLPTSQNSIHPVRVVNGQTATIAKTFPMAQLTSIVIATPGTRLAGPQTVQLSKPSLEKQ 339

  Fly  2598 --SSHPNTSDSDSDFGKRT------------------------------------KKKSGGKRRR 2624
              .||..|.:..::  .||                                    .|:...|||.
Human   340 TVKSHTETDEKQTE--SRTITPPAAPKPKREENPQKLAFMVSLGLVTHDHLEEIQSKRQERKRRT 402

  Fly  2625 SANNTNSS------------KYSNSLQN---------------------------CQFCTSGENE 2650
            :||...|.            .|.||..:                           .....|.|||
Human   403 TANPVYSGAVFEPERKKSAVTYLNSTMHPGTRKRGRPPKYNAVLGFGALTPTSPQSSHPDSPENE 467

  Fly  2651 DKLLLCDGCDKGYHTYCFKPKMD--NIP-----DGDWYCYECVNKATNERKCIVCGGHRPSPVGK 2708
                      |...|:.|...:.  ::|     |||          .:|..|.||   |.|  |:
Human   468 ----------KTETTFTFPAPVQPVSLPSPTSTDGD----------IHEDFCSVC---RKS--GQ 507

  Fly  2709 MIYCDLCPRAYHADCYIPPLLKVPRGKWYCHGCISRAPPPKKRSA---GGT-----SGSSSKSRR 2765
            ::.||.|.|.||.||..|||..:|:|.|.|..|..:.  .||..|   .||     |..:.|:.:
Human   508 LLMCDTCSRVYHLDCLDPPLKTIPKGMWICPRCQDQM--LKKEEAIPWPGTLAIVHSYIAYKAAK 570

  Fly  2766 DRDRESGGSAKRRSDNSKTPAMEHMQQQQMPLAGGDSHHHHHQQPPSLNSSHDESMNSLPAAPLS 2830
            :.:::.  ..|..||         ::|::..|         .|:...|::|..:.|..
Human   571 EEEKQK--LLKWSSD---------LKQEREQL---------EQKVKQLSNSISKCMEM------- 608

  Fly  2831 PAHSVVSATNYDDQHHANNSVDGSSRFHAHLIPPSNNGTAALLEDVPGGANVMPGV---YPVYTP 2892
                            .|..:......|:.            ||.|.....::.|:   .||.:.
Human   609 ----------------KNTILARQKEMHSS------------LEKVKQLIRLIHGIDLSKPVDSE 645

  Fly  2893 VAAGNFSAGLINQAPVQPAMPFANVVAMSPRAVTPTRTRTPTPTPAPT 2940
            ...|..|.|                    |....|....|.||.|:|:
Human   646 ATVGAISNG--------------------PDCTPPANAATSTPAPSPS 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tou	NP_001097270.1	HAT_MBD	953..1027	CDD:238691
		ZapA	1021..1127	CDD:294720
		MAP7	1043..1198	CDD:283355
		RILP-like	1085..>1179	CDD:304877
		DDT	1255..1317	CDD:280886
		WHIM1	1406..1455	CDD:292246
		WHIM3	2190..2224	CDD:292248	5/8 (63%)
		PHD_BAZ2A_like	2640..2685	CDD:277020	11/78 (14%)
		RanBP2-type Zn finger	2640..2659	CDD:275375	4/45 (9%)
		RanBP2-type Zn finger	2680..2698	CDD:275376	2/17 (12%)
		PHD	2695..2744	CDD:279022	22/48 (46%)
		Bromo_BAZ2A_B_like	3027..3123	CDD:99935
PHF21A	XP_011518459.1	ING	<382..544	CDD:331088	44/186 (24%)
PHF21A	XP_011518459.1	PHD_PHF21A	498..540	CDD:276998	21/46 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0383
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900