DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tou and Cecr2

DIOPT Version :9

Sequence 1:	NP_001097270.1	Gene:	tou / 36241	FlyBaseID:	FBgn0033636	Length:	3131	Species:	Drosophila melanogaster
Sequence 2:	XP_008761473.1	Gene:	Cecr2 / 500308	RGDID:	1564182	Length:	1465	Species:	Rattus norvegicus

Alignment Length:	1623	Identity:	302/1623 - (18%)
Similarity:	496/1623 - (30%)	Gaps:	515/1623 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1702 AACFGQDRFWRRYWKLPKAG---GIF----------IEALESA-QNDICDYHEALEAMDDKKDAN 1752
            ||..|:.|.|   |::|...   .:|          ||.||:| ..|..|:...|.|.
  Rat     8 AAGLGELRSW---WEVPAIAHFCSLFRTAFRLPDFEIEELEAALHRDDVDFISDLIAC------- 62

  Fly  1753 DEKENSENEKDVAAESSEQPME-VDESITKLEDGVP-----ASDVGMP-ESNQQNAHQ--DEEDD 1808
             ..:.....:|:..::....:| :.....:||:|.|     ||...:| .:..:..|:  |...|
  Rat    63 -LLQGCYQRRDITPQTFHSYLEDIINYRWELEEGKPNPLREASFQDLPLRTRVEILHRLCDYRLD 126

  Fly  1809 DDDVTEINK--------VEPEIVDLGDDDDDA------APPLPKIEPPRPEIKVKSEMELMGPPP 1859
            .|||.::.|        |||    ||:|:..|      ...:.|.:|    ::.:|..||
  Rat   127 ADDVFDLLKGLDADSLRVEP----LGEDNSGALYWYFYGTRMYKEDP----VQGRSNGEL----- 178

  Fly  1860 TTMISTKTDFEAEIKIPSMPGIL-----MPPTL--------------NNNNTNNNNNNNGSDNCD 1905
                |...:.|.:..:.::||..     .||..              .|:.|::....|||
  Rat   179 ----SLSRESERQKNVSNVPGKTGKRRGRPPKRKKLQEEIISSEKQEENSLTSDLQTRNGS---- 235

  Fly  1906 KLETGLGLG------QQQQNFSQSVIKTEDVKKEDDCIIVSTSSVDDTPKWFSIVRREVPLISEL 1964
               .|.|.|      |.::.:.|   .||..::.        :|:.:...:..:....:|.|..:
  Rat   236 ---RGPGQGTWWLLCQTEEEWRQ---VTESFRER--------TSLRERQLYKLLSEDFLPEICNM 286

  Fly  1965 PAEEGGVVGQELQISYANQNCSAQLQLQGHPWDLINNMQYYSIPMDECKVDTSKLGNECIFSLSG 2029
            .|::|          ...|....:||              :....|...:.::|
  Rat   287 IAQKG----------KRPQRTKPELQ--------------HRFMSDHLSIKSTK----------- 316

  Fly  2030 LDEKQMLAKVEEYKAHKVESKNGLGSPHRHHETKDDEEQAKLKLDKEIDTEMETDADDLAGKEKF 2094
            |:|..||.|:|:.|..:.|.:..|   ....:.|:.|:..|.:..:|::.:::. .:|.|.:.|.
  Rat   317 LEETPMLTKIEKQKRKEEEEERQL---LLAVQKKEQEQMLKEERKRELEEKVKA-VEDRAKRRKL 377

  Fly  2095 FRLRS-------DVPP-----DTGGGVSEGTDVKPKIELRLD-----EALSQAYYHNIANMSLSS 2142
            ...|:       ::||     |....:.||...|...||..|     :.|.....|..:...|..
  Rat   378 REERAWLLAQGKELPPELSHLDLNSPMREGKKTKDIFELDDDFTAMYKVLDVVKAHKDSWPFLEP 442

  Fly  2143 V-QTYIP-----IDIPLPLSMTPDEHRLLEQVKLAGFPERVHGVYVPRRQRYGWWQLDDEQKLRQ 2201
            | ::|.|     |.||:.:|..        :.||.|      |:|..:.:     .::|.:.:.:
  Rat   443 VDESYAPNYYQIIKIPMDISSM--------EKKLNG------GLYCTKEE-----FVNDMKTMFR 488

  Fly  2202 LLKTLNPSGLRERELQENLQR---------FLGLEQPLGVNYKLKSDIDFPEEFLMPDKKGDWNP 2257
            ..:..|.......::.|||:|         |.|            .|.|..|||        |..
  Rat   489 NCRKYNGDSSEYTKMSENLERCFHRAMTKHFPG------------EDGDTDEEF--------WIR 533

  Fly  2258 KVAKRVELALIEQLESLEDKVASASMQLKNWQLPNRVESELTLDSQEDVTEEDFVSIIPMIRERI 2322
            :..||      |:..|...:.:.:.:    |......|..   ..::...|....|:.|..|...
  Rat   534 EDEKR------EKRRSRAGRSSGSHV----WTRSRDTEGS---SRKQPPMENGGKSLPPARRAAS 585

  Fly  2323 IDLEANIERRYLKPPLGSQTG-----DAHLAVIAQNQHTTTQTQNSASAAAYLLQMQQQQQQQQL 2382
            ...:.:.....|.|.:|:..|     ..|.:.:........|.:.:||.....||
  Rat   586 SGDDQSSSSIQLPPEVGTSNGRGFFHPLHYSRVPSQAPPLNQMRPAASGTFGSLQ---------- 640

  Fly  2383 AQQQQQQQQGSG------AGNSLNPSSF---------NERTMALAAAAAASGP-----GNATGVA 2427
             ........||.      .|..|....|         |.|...|:|      |     |..|.::
  Rat   641 -GSDPTNLHGSSRIPEVPPGEPLQHPPFAIQAPVGISNHRGSRLSA------PEEKMCGGLTHLS 698

  Fly  2428 N-----SAVVAGATPCESGSGE------------PNSGNASPASNCDSDRDEKVEQIPKGLVQWR 2475
            |     .::..|...|.|..|.            |:....:||.  ..|..|..|..|..:....
  Rat   699 NMGSHVPSLQLGQMNCNSQDGNIYPPAPFQAGFIPSRHGGTPAR--PPDFPESSEIPPSHIYHSY 761

  Fly  2476 DAVSRSHTTAQLAMALYVLESCVAW-----------------------------------DKSIM 2505
            ..::|.|.              ..|                                   |..:|
  Rat   762 KYLNRVHP--------------AVWNGNHGTTNPGRLGPDEKPLVGPGASHHPHALGHMMDGRVM 812

  Fly  2506 KAYATKNKSSKKKSSAKKQATPSKKQQQKKNKKE-QQLTPNGKESKSKSAINKPENQAPLSIKIN 2569
            :.....|:.: |:||......||....|...|.. .:|.|....:.|      |..:.|
  Rat   813 RQPIPPNQWT-KQSSFLPPGVPSSGYMQPPCKSAGHRLQPPPTPAPS------PRFRGP------ 864

  Fly  2570 LKAL--AQNGQCLL------------------------KTKTPPIL-----------------TK 2591
            .:||  ||.|:.::                        :..|||.|                 .|
  Rat   865 SQALRGAQGGESMMDSPEMIAMQQLSSRVCPPGVPYHPRQPTPPQLPGPFPQVAHSASVCVSAPK 929

  Fly  2592 SPTASPSSHPNTSDSDSDFGKRTKKKSGGKRRRSANNTNSSKYSNSLQN-----CQFCT------ 2645
            ....:|.|....|::....|.|.:...|.:.:.::..::...|...|.:     ...||
  Rat   930 PALDNPGSTQEISETQEPEGDRAEPVPGLEEKAASICSSEGLYLKQLPHPAPPLSASCTRQSSPH 994

  Fly  2646 SGENEDKLLLCDGCDKGYHTYCFKPKMDNIPDGDWYCYECVNKAT--------NERKCIVCGGHR 2702
            ..|.||..|..|..|.. .||  |...:..|   |......|.|.        .:...:...|:.
  Rat   995 ERETEDSQLKSDASDSA-DTY--KASKNKNP---WPLDNSYNSAAVQGALHGGRDLAIVTERGNL 1053

  Fly  2703 P--SPVGKMIYC--------------DLCPR--------------AYHADCYIPPL--------- 2728
            |  ..||:...|              .||||              |....|..|.|
  Rat  1054 PENGVVGEASPCRSEGKGLGGSGSEKPLCPRGKTLQETVPCTGQNATTPPCTDPNLMAGTVNQFS 1118

  Fly  2729 -LKVPRGKWYCHGCISRAPPPKKRSAGGTSGSSSKSRRDRDRESGGSAKRRSDNSKTPAM--EHM 2790
             |.:| |..|.:........|..:..|...|:.|..    .:....|.:....|...|.:  .:.
  Rat  1119 PLYMP-GIEYSNSATHYPMSPSLQGLGSMMGAKSPG----SQPQSFSPRSFQANGPHPGLFPRYR 1178

  Fly  2791 QQQQMPLA---GGDSHHHHHQQPP--SLNSSHDESMNSLPA--APLSPAHSVVSATNYDDQHHAN 2848
            .||.|..:   .....:|.:|:.|  :......:...|||:  :|..|..|......:.|: :|.
  Rat  1179 PQQGMRYSYQPSSQPSYHPYQRTPYYTCPQGFSDWQRSLPSQRSPSGPPGSHPPRPLFSDK-NAL 1242

  Fly  2849 NSVDGSSRFHAHLIPPSNNGTAALLEDVPGGANVMP-------GVYPVYTP---VAAGNFSAGLI 2903
            .|:.|....:|.|..|:.....|.....|.|.|..|       .:....:|   :...|.:|...
  Rat  1243 TSLQGCETLNAALTSPTQMDAVAAKVVPPDGHNSGPEEEKMDESMERPESPKEFLDLDNHNAATK 1307

  Fly  2904 NQA--------------PVQPAMPFANVVAMSPRAV--------TPTRTRT---PTPTPAPTPPP 2943
            .|:              |:...|.|.: .|..|.:|        ||.|:.:   |....:|.|..
  Rat  1308 RQSSLSTNDYLYGAPPPPLSSGMTFGS-SAFPPHSVMLQTGSPYTPQRSASHFQPRAYASPVPAH 1371

  Fly  2944 PPPTPLLMQASPTATALHVNACQSPPQQQHAQLMTMPSPPAIGV-GTATNQMSPPPINIHAIQ 3005
            |||.|:..|.:..:....:..||..........|...:....|: |:..:...||.:.:|.||
  Rat  1372 PPPHPVATQPNGLSPEGPLYCCQEEGLGHFQAAMMEQTGTGSGIRGSFQDAHRPPGLQMHPIQ 1434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tou	NP_001097270.1	HAT_MBD	953..1027	CDD:238691
		ZapA	1021..1127	CDD:294720
		MAP7	1043..1198	CDD:283355
		RILP-like	1085..>1179	CDD:304877
		DDT	1255..1317	CDD:280886
		WHIM1	1406..1455	CDD:292246
		WHIM3	2190..2224	CDD:292248	6/42 (14%)
		PHD_BAZ2A_like	2640..2685	CDD:277020	13/55 (24%)
		RanBP2-type Zn finger	2640..2659	CDD:275375	7/29 (24%)
		RanBP2-type Zn finger	2680..2698	CDD:275376	3/25 (12%)
		PHD	2695..2744	CDD:279022	17/88 (19%)
		Bromo_BAZ2A_B_like	3027..3123	CDD:99935
Cecr2	XP_008761473.1	WHIM3	244..284	CDD:292248	6/50 (12%)
Cecr2	XP_008761473.1	Bromo_gcn5_like	418..518	CDD:99941	22/118 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900