DRSC/TRiP Functional Genomics Resources

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Protein Alignment tou and polybromo

DIOPT Version :9

Sequence 1:NP_001097270.1 Gene:tou / 36241 FlyBaseID:FBgn0033636 Length:3131 Species:Drosophila melanogaster
Sequence 2:NP_651288.1 Gene:polybromo / 42954 FlyBaseID:FBgn0039227 Length:1654 Species:Drosophila melanogaster


Alignment Length:1767 Identity:305/1767 - (17%)
Similarity:579/1767 - (32%) Gaps:654/1767 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly  1044 DEDVAKRLED-------LKVFTRQTLNVEQRIEIAKQQQAMRDA-KKLQKE-------------- 1086
            ||| ..:|:|       ::..|.|:...::|::..:..|.:.|: :.::||              
  Fly    16 DED-PLQLDDSTPEQSPVQQTTTQSARKKRRLDPTELCQQLYDSIRNIKKEDGSMLCDTFIRVPK 79

  Fly  1087 ---------------ELARNKEKARQEKNSKLEQQRKDKEL--------------KNQQAV---- 1118
                           :|.:.::|.:.:....|:....|.||              ::|.||    
  Fly    80 RRQEPSYYDVVVNPIDLLKVQQKLKTDSYDDLDDLMADLELLIGNAKAFYIPGSSEHQDAVSLWQ 144

  Fly  1119 --EERKKRQEELDRLKQEELLKKQQEKEKRRQEAIL------AKEQELQKQKEM----LLAAEME 1171
              ..:::|..|.:.|.:||...::..::.||..:..      |.:.|..:.:|:    :.|.:..
  Fly   145 HIHSQRQRIMEANGLAEEEPRARRMSRQVRRMTSSTEPGGDGATDDEYNQYEELFASVMTATDPV 209

  Fly  1172 RERRRQHMSLIRMLELRRKFED-REKKKHQLVLDRLLLRERRM------AERKRDAEILQLIRRP 1229
            .:|....|  .::|..::.:.| .:..:|.:.| ||:..:.:|      ||.:||  :||:.:..
  Fly   210 GDRLMHRM--FQLLPSKKIYPDYYDVIEHPIDL-RLIATKIQMNAYSSLAEMERD--LLQMTKNA 269

  Fly  1230 NEDSEMPQELV--IPELDRIAGNR-----------------LPGQAMADL--------------- 1260
            ...:|...::.  ...|.||...|                 |...|:|.|               
  Fly   270 CLFNEPGSQIYKDAKSLKRIFTQRRIELEMGKGKLAKRVKSLSSAAIAALKEEVDSSDDEETSKK 334

  Fly  1261 -----LMVFEFLHN----------FGETLGFDMESLP----------------SLQNLHDALMSD 1294
                 ..:|:.|:|          .|..||..:..||                |:..:|..|...
  Fly   335 GEGPMWALFDHLYNAPGTSEHPGVTGPPLGNSLWKLPVRRFHPEYFELIKRPISMSQIHTKLKKG 399

  Fly  1295 SNADAEEELLSVMTHLLVCAIEDPGVPNPGRHTT----LLGQSLRNADITNSNVSEILRIYLYAT 1355
            ..|:     :|.:|..|...:::.....|..|.|    |....|.||.:...::.|...:   ..
  Fly   400 DYAN-----ISDLTADLYLMLDNAKKAFPTSHRTHKDALKMLKLMNAKLVEESLEEGSDL---DD 456

  Fly  1356 ATGEVRQMHGITVDRERERRVPDHHQLDSDTTTH-SHSVKNQEYYKLLHENDTWKLSQSLKDRPF 1419
            ...|.......||..:.|:|.|...:::|::.:: ||:..|               |.|.|.   
  Fly   457 EDAEEMDTEVFTVSTQPEKRKPGRPRINSNSNSNASHTPNN---------------SNSPKS--- 503

  Fly  1420 VALNPTRKAQMLAHLCNDLLMNKAVLRQIDGSLETCAQMRKEKYMTDMKVRKYKALHM------R 1478
                            |.:.:|.|:.::|         :..:||:.|..:...:.:.|      |
  Fly   504 ----------------NRIAINAAIKKKI---------LSIQKYLVDYSLGNRRPIEMFMEKPPR 543

  Fly  1479 KARIEAYERAQ-------------AEREAAMQALMAQQKLDAERLKAEEEAKAAAAEEAAAAAGT 1530
            |...:.|:..|             .:|.||::.:::..:|.....:...|..:...|:|......
  Fly   544 KIYPDYYDIIQNPIDMNTIEHNIRTDRYAAVEDVVSDYRLMFSNCRQYNEEGSNIYEDANILERA 608

  Fly  1531 DGEATKGGSPNGEKP--EDGDQNEEGAAK------------------EPQQQQQQPMEVDGVVDE 1575
            ..|..|      |.|  .:|.::::..:|                  |..::.|:|         
  Fly   609 LNEKLK------EFPGLTEGKKSQQKYSKVGRKLKTAVITERLWQFYETVKEYQEP--------- 658

  Fly  1576 ASLVSPAKTIIQTDNSLTPSKQDMPTPTYQINGSSTPTTSGVTGGDMNVLLQAKKSGARNSIND- 1639
                 ..|..:....:..|||.:.| ..|.|.....         ||:.:.|..|.||.::::| 
  Fly   659 -----KGKRQLSLIFTKLPSKSEYP-DYYDIIREPI---------DMDRIAQKLKQGAYDTLDDL 708

  Fly  1640 -------------------EHHHDVSIID--------------DDLSDLDSEITNV--------- 1662
                               :.:.|..::.              |.|.|:...:..:         
  Fly   709 AADFLLMLENACKYNEPDSQIYKDALVLQQLTLQLKQQLRTERDSLPDVPLAVQELFLTLFTTIY 773

  Fly  1663 -EEDEDNRLSADELQK--KLDKI-----VRA-SLN-CKEALEKSTNQLRAACFGQDRF--WRRYW 1715
             .:||:.|..:|.|.:  :.|:|     ||. ||: .|..|:|...: |...:.:|.|  ..|..
  Fly   774 NHQDEEGRCYSDSLAELPEYDEIGEGPKVRGISLDLVKRRLDKGAYK-RLDVYQEDIFACLERAR 837

  Fly  1716 KLPKA-GGIFIEALE------SAQNDICDYHEALEAMDDKKDANDEKENSENEKDVAAESSEQPM 1773
            ||.:. ..||.:::|      ..::::|                         ||..:.|:    
  Fly   838 KLSRTDSDIFQDSIELQTYFIRKRDELC-------------------------KDTLSSSA---- 873

  Fly  1774 EVDESITKLEDGVPASDVGMPESNQQNAHQDEEDDDDD--VTEINKVEPEIVDLGDDDDDAAPPL 1836
             ::.|:.:|     .:||.:  ..||...|:|:|.:.|  ..|.|..:.|.:.:   :.....|.
  Fly   874 -LNFSLERL-----MADVEL--CRQQKMQQEEQDQEQDKEKDEFNAAKGESMTI---NQQVFSPG 927

  Fly  1837 PKIEPPRPEIKVKS------------EMELM------GPPPTTMISTKTDFEAEIKIPSMPGILM 1883
            ..:....||.|:.|            ..:||      .|..|..::|:...|.|:...|:...: 
  Fly   928 DYVYVQMPENKIPSICCIERLWTSPTNEKLMQASIFVRPHETYHVTTRKFLEKEVFKSSLSQTI- 991

  Fly  1884 PPTLNNNNTNNNNNNNGSDNCDKLETGLGLGQQQQNFSQSVIKTEDVKKEDDCIIVSTSSVDDTP 1948
                               :.||:: |:......:::.:  ::.|::.::|  :.|..|..:...
  Fly   992 -------------------SMDKVQ-GMCYVMNIKDYIK--MRPENLPEKD--VYVCESRYNIQG 1032

  Fly  1949 KWF---------------SIVRREVPL-------------------ISELPAEEGGVVGQELQIS 1979
            :||               ..|.||.||                   :.||..:|..|..::..:|
  Fly  1033 RWFKKLKSWPPVREGSSVKFVPREQPLELKRVMSVFKERLEKHKGELEELKLQETLVEKEKPNVS 1097

  Fly  1980 -------------YANQN--CS--------------------AQLQLQGHPWDLINNMQYYS--- 2006
                         |...|  ||                    ||:|   ..|:. |...|:.   
  Fly  1098 CDPPPNAEVGSTYYQQYNTICSGAIKTGDFVYVATQTGKQSVAQVQ---QIWEQ-NGKSYFKGPW 1158

  Fly  2007 -IPMDECKVDTSKLGNECIFSLSGLDEKQMLAKVEEY--------KAHKVESKNGLGSPHRHHET 2062
             :|..|   .|..||.:.      ..::.:|:.|||.        :...:|....:.|  |..|.
  Fly  1159 LLPPSE---TTPGLGKQF------YRQELLLSTVEEVSPVVGIVGRCAVLEYSEFISS--RPTEI 1212

  Fly  2063 KDDE--------EQAKLKLDKEIDTEM-ETDADDLAGKEKFFRLRSDVPPDTGGGVSEGTDVKPK 2118
            .:.:        ::.|..|.|.:...| :........:::.|..::.:.|        ..|.|.:
  Fly  1213 SESDVYICESVYDELKKALRKLVTGNMRKFQHSPSVTEDEIFYFKTPIKP--------SKDFKNE 1269

  Fly  2119 I-EL-RLDEAL---SQAYYHNIANMSLSSVQTYIPIDIPLP-LSMTPDEHRLLEQVKLAGFPERV 2177
            : || .|::::   :.:...:||.||           .|.| ::.||    |..:||.|...::.
  Fly  1270 LNELGMLEDSMDGDTPSLSSDIAAMS-----------SPAPSVNSTP----LTSKVKAAKSAKKC 1319

  Fly  2178 HGVYVPRRQRYGWWQLDDEQKLRQLLKTLNPSGLRERELQENLQRFLG-LEQPLGVNYK-LKSDI 2240
            ...|:                       |..|.:|:...|.|.....| :.:.:|..:| |.|.:
  Fly  1320 LTGYI-----------------------LYSSEVRKSICQSNPDATFGDISRMVGTEWKNLPSSV 1361

  Fly  2241 DFPEEFLMPDKKGDWNPKVAKRVE--LALIEQLESLEDKVASASMQLKNWQLPNRVESE-LTLDS 2302
                       |..|..:.:::.|  .||..:|:.:::..:.:|      |:...|..: ||.:.
  Fly  1362 -----------KQSWEDRASRQNEETAALRRELDDVQNSASPSS------QVSQDVFGQVLTFEC 1409

  Fly  2303 QEDVTEEDFVSIIPMIRERIIDLEANIERRYLKPPLGSQT------------------------- 2342
            |.|..:..|..:.......:.|...:|:|.   |..|.:|                         
  Fly  1410 QWDKCDFQFEELSDCTEHCMSDSTGHIQRH---PQAGVETEYVCLWRNCPRVKKSVQAFPNVLRL 1471

  Fly  2343 ----GDAHLAVIAQNQHTTTQTQN-----------------------SASAAAYL--LQMQQQQQ 2378
                .:.||:...:......:::|                       |..|.:.|  :|:||||.
  Fly  1472 IKHVREVHLSKCGKTISAADRSKNFVPRRQKHAQLATTVPIPPSLAQSPRAPSNLEAVQLQQQQH 1536

  Fly  2379 QQQLAQQQQQQQ 2390
            .||...|.||||
  Fly  1537 PQQNMHQLQQQQ 1548

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
touNP_001097270.1 HAT_MBD 953..1027 CDD:238691
ZapA 1021..1127 CDD:294720 22/139 (16%)
MAP7 1043..1198 CDD:283355 36/221 (16%)
RILP-like 1085..>1179 CDD:304877 23/152 (15%)
DDT 1255..1317 CDD:280886 18/107 (17%)
WHIM1 1406..1455 CDD:292246 7/48 (15%)
WHIM3 2190..2224 CDD:292248 5/33 (15%)
PHD_BAZ2A_like 2640..2685 CDD:277020
RanBP2-type Zn finger 2640..2659 CDD:275375
RanBP2-type Zn finger 2680..2698 CDD:275376
PHD 2695..2744 CDD:279022
Bromo_BAZ2A_B_like 3027..3123 CDD:99935
polybromoNP_651288.1 Bromodomain 46..158 CDD:295360 15/111 (14%)
Bromo_polybromo_II 191..294 CDD:99948 22/107 (21%)
Bromo_polybromo_III 335..443 CDD:99951 22/112 (20%)
Bromo_polybromo_IV 512..613 CDD:99949 17/109 (16%)
Bromo_polybromo_V 641..733 CDD:99946 17/115 (15%)
Bromo_polybromo_VI 758..867 CDD:99956 24/134 (18%)
BAH_polybromo 921..1040 CDD:240068 22/143 (15%)
BAH_polybromo 1120..1234 CDD:240068 21/128 (16%)
HMG-box 1320..1375 CDD:238037 13/88 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5076
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.900

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