DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tou and Cecr2

DIOPT Version :9

Sequence 1:	NP_001097270.1	Gene:	tou / 36241	FlyBaseID:	FBgn0033636	Length:	3131	Species:	Drosophila melanogaster
Sequence 2:	NP_001355635.1	Gene:	Cecr2 / 330409	MGIID:	1923799	Length:	1453	Species:	Mus musculus

Alignment Length:	1938	Identity:	333/1938 - (17%)
Similarity:	546/1938 - (28%)	Gaps:	793/1938 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly  1281 LP--SLQNLHDALMSDSNADAEEELLSVMTHLLVCAIE--------------------------- 1316
            ||  .::.|..||..|   |.|     .::.|:.|.::
Mouse    36 LPDFEIEELEAALHRD---DVE-----FISDLIACLLQGCYQRRDITPQTFHSYLEDIINYRWEL 92

  Fly  1317 DPGVPNPGRHTTLLGQSLRNA------------------DITNSNVSEILRI------------- 1350
            :.|.|||.|..:.....||..                  |:.....::.||:
Mouse    93 EEGKPNPLREASFQDLPLRTRVEILHRLCDYRLDADDVFDLLKGLDADSLRVEPLGEDNSGALYW 157

  Fly  1351 YLYATATGEVRQMHG-----ITVDRERERR-----VP--------------------------DH 1379
            |.|.|...:...:.|     :::.||.||:     ||                          :.
Mouse   158 YFYGTRMYKEDPVQGRSNGELSLCRESERQKNVSNVPGKTGKRRGRPPKRKKLQEEIISSEKQEE 222

  Fly  1380 HQLDSDTTTH--SHSVKNQEYYKLLHENDTWK-LSQSLKDRPFVALNPTRKAQMLAHLCNDLLMN 1441
            :.|.||..|.  |.......::.|....:.|: :::|.::|     ...|:.|:...|..|.|.
Mouse   223 NSLTSDLQTRNGSRGPGQGTWWLLCQTEEEWRQVTESFRER-----TSLRERQLYKLLSEDFLP- 281

  Fly  1442 KAVLRQIDGSLETC---AQMRK----------EKYMTD---MKVRKYKALHMRKARIEAYERAQA 1490
                       |.|   ||..|          .::|:|   :|..|.:...| ..:||..:|.:.
Mouse   282 -----------EICNMIAQKGKRPQRTKPELQHRFMSDHLSIKSIKLEETPM-LTKIEKQKRREE 334

  Fly  1491 EREAAMQALMAQQKLDAERLKAEEEAKAAAAEEAAAAAGTDGEATKGGSPNGEKPEDGDQNEEGA 1555
            |.|  .|.|:|.||.:.|::..||..:                               :..|:..
Mouse   335 EEE--RQLLLAVQKKEQEQMLKEERKR-------------------------------EMEEKVK 366

  Fly  1556 AKEPQQQQQQPMEVDGVVDEASLVSPAKTIIQTDNSLTP--SKQDMPTPTYQINGSSTPTTSGVT 1618
            |.|.:.::::..|     :.|.|::..|       .|.|  |..|:.:|
Mouse   367 AVEDRAKRRKLRE-----ERAWLLAQGK-------ELPPELSHLDLNSP---------------- 403

  Fly  1619 GGDMNVLLQAKKSGARNSINDEHHHDVSIIDDDLSDLDSEITNVEEDEDN--------------- 1668
                  :.:.||:           .|:..:|||.:.:...:..|:..:|:
Mouse   404 ------MREGKKT-----------KDLFELDDDFTAMYKVLDVVKAHKDSWPFLEPVDESYAPNY 451

  Fly  1669 ------RLSADELQKKLDKIVRASLNCKEALEKSTNQLRAACFGQDRFWRRYWKLPKAGGIFIEA 1727
                  .:....::|||:    ..|.|.:  |:..|.::.    ..|..|:|      .|...|.
Mouse   452 YQIIKIPMDISSMEKKLN----GGLYCNK--EEFVNDMKT----MFRNCRKY------NGDSSEY 500

  Fly  1728 LESAQN-DICDYHEAL------------EAMDDKKDANDEKENSEN-----------EKDVAAES 1768
            .:.:.| :.| :|.|:            |....|:|...||..|.:           .:|....|
Mouse   501 TKMSDNLERC-FHRAMTKHFPGEDGDTDEEFWIKEDEKREKRRSRSGRSSGSHVWTRSRDTEGSS 564

  Fly  1769 SEQPMEVDESITKLEDGVPASDVGMPESNQQNAHQDEEDDDDDVTEINKVEPEIVDLGDDDDDA- 1832
            .:||        .:|:|    ...:|.     |.:.....||......::.||:   |......
Mouse   565 RKQP--------PVENG----GKSLPP-----ARRAASSGDDQSRSSIQLPPEV---GTSHGQGF 609

  Fly  1833 ------------APPLPKIEPPRPEIKVKSEMELMGPPPTTMISTKTDFEAEIKIPSMP------ 1879
                        ||||.::.|..|    .:...|.|..||.:       ....:||..|
Mouse   610 SRPLHCGRVPSHAPPLNQMRPAAP----GTFGSLQGSDPTNL-------HGSSRIPEAPPGEPLQ 663

  Fly  1880 -----------------GILMPPTLNNNNTNNNNNNNGSDNCDKLETGLGLGQQQQNFSQSVIKT 1927
                             .:|..|.|:|..::..:...|..||...:   |.......|....|.:
Mouse   664 HPPFAIQAPVGISNHRGSLLSAPDLSNMGSHVPSLQLGQMNCPSQD---GNMYPPAPFQAGFIPS 725

  Fly  1928 EDVKKEDDCIIVSTSSVDDTPKWFSIVRREVPLISELPAEEGGVVGQELQISYANQNCSAQLQLQ 1992
            ..            ......|..|       |..||:|.       ..:..||...|       :
Mouse   726 RH------------GGTPARPPDF-------PESSEIPP-------GHIYHSYKYLN-------R 757

  Fly  1993 GHP--WDLINNMQYYSIPMDECKVDTSKLGNECIFSLS--GLDEKQMLAKVEEYKAHKVESKNGL 2053
            .||  |:                      ||....:..  |.|||..|               |.
Mouse   758 AHPAVWN----------------------GNHGTTNPGRLGPDEKPHL---------------GP 785

  Fly  2054 GSPHRHHETKDDEEQAKLKLDKEIDTEMETDADDLAGKEKFFRLRSDVPPDTGGGVSEGTDVKPK 2118
            |..|..|           .|...:|..:               :|..:||:
Mouse   786 GPSHHPH-----------TLGHMMDGRV---------------MRQPIPPN-------------- 810

  Fly  2119 IELRLDEALSQAYYHNIANMSLSSVQTYIPIDIPLPLSMTPD----EHRLLEQVKLAGFPERVHG 2179
                                ..:...:::|..:|....|.|.    .|||......|..| |..|
Mouse   811 --------------------QWTKQSSFLPHGVPSSGYMQPPCKSAGHRLQPPPTPAPSP-RFRG 854

  Fly  2180 VYVPRRQRYGWWQLDDEQKLRQLLKTLNPSGLRERELQENLQRFLGLEQ------PLGVNYKLKS 2238
                           ..|.||         |.:..|...:....:.::|      |.||.|
Mouse   855 ---------------PSQALR---------GAQGGESMMDSPEMIAMQQLSSRVCPPGVPY---- 891

  Fly  2239 DIDFPEEFLMPDKKGDWNPKVAKRVELALIEQLESLEDKVASASMQLKNWQLPNRVESELTLDSQ 2303
               .|.:...|...|.: |:||....:.:.....:|::..::..|                  ::
Mouse   892 ---HPRQPTPPQLPGPF-PQVAHSASVCVSAPKPALDNPGSTQEM------------------TE 934

  Fly  2304 EDVTEEDFVSIIPMIRERIIDLEANIERRYLKPPLGSQTGDAHLAVIAQNQHTTTQTQNSASAAA 2368
            ....|||....:|...|:...: .:.|..|||                |..|.....|.|.:
Mouse   935 THEPEEDPAEPLPGHEEKAASI-CSSEGVYLK----------------QLPHPAPPLQASCT--- 979

  Fly  2369 YLLQMQQQQQQQQLAQQQQQQQQGSGAGNSLNPSSFNERTMAL---AAAAAASG----------P 2420
                 :|...|::..:..|.:...|.:.::...|. |:.|..|   .::.|..|          .
Mouse   980 -----RQSSPQERETEDSQLKSDASDSADTYKTSK-NKNTWPLDNSYSSPAVQGCLRDLSIVAET 1038

  Fly  2421 GNATGVANSAVVAGATPCES-GSGEPNSGNASPASNCDSDRDEKVEQIPKGLVQWRDAVSRSHTT 2484
            ||   :..:.||..|:||.| |.|...||:..|.  |           |:|.. .::||..:...
Mouse  1039 GN---LPENGVVGEASPCRSEGKGLDGSGSEKPL--C-----------PRGKT-LQEAVPCTGPN 1086

  Fly  2485 AQLAMALYVLESCVAWDKSIMKAYATK------------NKSSKKKSSAKKQATPSKKQQQKKNK 2537
            |       ....|.  |.|:|.|...:            |.:::...|...|...|....:....
Mouse  1087 A-------TTPPCT--DPSLMAATVNQFSPLYMPGIEYSNSATQYPMSPSLQGLASMMGGKSSGS 1142

  Fly  2538 KEQQLTPNGKESKSKSAINKPENQAPLSIKINLKALAQNGQCLLKTKTPPIL------------- 2589
            :.|...|.|.::........|..:....::.:.:..:|......: :||...
Mouse  1143 QPQSFPPRGFQANGPHPGLFPRYRPQQGMRYSYQPPSQPSYHPYQ-RTPYYTCPQGFSDWQRSLP 1206

  Fly  2590 -TKSPTASPSSHPNTSDSDSDFGKRTKKKSGGKRRRSANNTNSSKYSNSLQNCQ----FCTSGEN 2649
             .:||:..|.|||..|                  ..|..|..|     |||.|:    ..||...
Mouse  1207 SQRSPSGPPGSHPPRS------------------LFSEKNVLS-----SLQGCETLNTALTSPTQ 1248

  Fly  2650 ED----KLLLCDGCDKGYHTYCFKPKMDNIPDGDWYCYECVNKATNERKCIVCGGHRPSP--VGK 2708
            .|    |::..||.:.|..    :.|||          |.|.:..:.::.:....|..:.  ...
Mouse  1249 MDVVTAKVVPPDGHNSGPE----EEKMD----------ESVERPESPKEFLDLDNHNAATKRQNS 1299

  Fly  2709 MIYCDLCPRAYHADCYIPPLLKVPRGKWYCHGCISRAPPPKKRSAGGTSGSSSKSRRDRDRESGG 2773
            :...|                       |.:|     .||...|:|.|.|||:
Mouse  1300 LSTSD-----------------------YLYG-----TPPPSLSSGMTFGSSA------------ 1324

  Fly  2774 SAKRRSDNSKTPAMEHMQQQQMPLAGGDSHHHHHQQPPSLNSSHDESM---NSLPAAPLSPAHSV 2835
                      .|....|.|...|..            |..::||.:..   :.:||.|  |.|.|
Mouse  1325 ----------FPPHSVMLQTGSPYT------------PQRSASHFQPRAYPSPVPAHP--PPHPV 1365

  Fly  2836 VSATN---YDDQHHANNSVDGSSRFHAHLIPPSNNGTAALLEDVPGGANVMPGVYPVYTPVAAGN 2897
            .:..|   .:|..:.... :|...|.           |:::|....|:.:......|:.|..
Mouse  1366 ATQPNGLSPEDSLYCCQE-EGLGHFQ-----------ASMMEQTGTGSGLRGSFQEVHRPPG--- 1415

  Fly  2898 FSAGLINQAPVQPAMPFANVVAMSPRAVTPTRTRTPTPTPAPTPPPPPPTPLL 2950
                 :...|||....|               .:||.|..:|...||..||.|
Mouse  1416 -----LQMHPVQSQSLF---------------PKTPAPAASPEQLPPHKTPTL 1448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tou	NP_001097270.1	HAT_MBD	953..1027	CDD:238691
		ZapA	1021..1127	CDD:294720
		MAP7	1043..1198	CDD:283355
		RILP-like	1085..>1179	CDD:304877
		DDT	1255..1317	CDD:280886	10/64 (16%)
		WHIM1	1406..1455	CDD:292246	9/49 (18%)
		WHIM3	2190..2224	CDD:292248	5/33 (15%)
		PHD_BAZ2A_like	2640..2685	CDD:277020	11/52 (21%)
		RanBP2-type Zn finger	2640..2659	CDD:275375	6/26 (23%)
		RanBP2-type Zn finger	2680..2698	CDD:275376	2/17 (12%)
		PHD	2695..2744	CDD:279022	4/50 (8%)
		Bromo_BAZ2A_B_like	3027..3123	CDD:99935
Cecr2	NP_001355635.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..237		12/66 (18%)
		Bromo_gcn5_like	418..518	CDD:99941	20/116 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	536..667		29/161 (18%)
		PHA03247	<558..1031	CDD:223021	116/713 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..796		10/54 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	827..868		14/65 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	884..1020		33/187 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1046..1072		12/38 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1131..1308		37/237 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1331..1368		12/50 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1396..1453		16/76 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900