DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tou and Ep300

DIOPT Version :9

Sequence 1:	NP_001097270.1	Gene:	tou / 36241	FlyBaseID:	FBgn0033636	Length:	3131	Species:	Drosophila melanogaster
Sequence 2:	XP_006521152.1	Gene:	Ep300 / 328572	MGIID:	1276116	Length:	2422	Species:	Mus musculus

Alignment Length:	949	Identity:	195/949 - (20%)
Similarity:	305/949 - (32%)	Gaps:	300/949 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  2286 KNWQLPNRVESELTLDSQEDVTEEDFVSIIPMIRERIIDLEANIERRYLKPPLGSQTGDAHLAVI 2350
            |:.|:.:...|...:...::.|..|....:|:       ..|..:|.......|:..|..:.:.:
Mouse   387 KSCQVAHCASSRQIISHWKNCTRHDCPVCLPL-------KNAGDKRNQQSILTGAPVGLGNPSSL 444

  Fly  2351 AQNQHTT------TQTQNSASAAAYL---LQMQQQQ---QQQQLAQQQQQQQQGSGAGNSLNPSS 2403
            ...|.:|      :|...|:...||.   |..|..|   |.|..|:.||.|..|.......:.::
Mouse   445 GVGQQSTPSLSTVSQIDPSSIERAYAALGLPYQVNQIPPQPQVQAKNQQSQPSGQSPQGMRSVNN 509

  Fly  2404 FNERTMALAAAAAASGPGNATGVANSAVVAGATPCES-GSGEPNSGNASPASNCDSDRDEKVEQI 2467
            .:...|.:........|...:.....:.:....|..| .:|..:.|....|:...|....|
Mouse   510 MSASPMGVNGGVGVQTPNLLSDSMLHSTINSQNPMMSENAGVASLGPLPTAAQPSSTGIRK---- 570

  Fly  2468 PKGLVQWRDAVS---RSHTTAQLAMALYVLESCVAWDKSIMK---AYATKNKSSKKKSS------ 2520
                 ||.:.::   |:|...:|..|::......|.....|:   |||.|.:....:|:
Mouse   571 -----QWHEDITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANNRAEY 630

  Fly  2521 ----AKKQATPSKKQQQKKNKK--EQQLTPNGKESKSKSAINKPEN--QAPLSIKIN-------- 2569
                |:|.....|:.::|:..:  :|.:.||. .......:|...|  |.|..:..|
Mouse   631 YHLLAEKIYKIQKELEEKRRTRLQKQNMLPNA-PGMGPVPMNTGSNMGQQPTGMTTNGPVPDPSM 694

  Fly  2570 ---------------LKALAQNGQCLLKTKTPPILTKSPTASP-SSHPNTSDSDS-----DFGKR 2613
                           ...|.|.||  :....|||..:.|  || ..|...:.|.|     .:|.|
Mouse   695 IRGSVPNHMMPRMTPQPGLNQFGQ--MNMPQPPIGPRQP--SPLQHHGQLAQSGSLNPPMGYGPR 755

  Fly  2614 TKKKSGGKRRRSANNTNSSKYSNSLQNCQFCTSGENEDKLLLCDGCDKGYHTYCFKPKMDNIPDG 2678
            .::.||              .:..|...||.:.|.|...:.|.             |.....|
Mouse   756 MQQASG--------------QNQFLSQTQFTSQGMNVTNMPLA-------------PSSGQAP-- 791

  Fly  2679 DWYCYECVNKA-TNERKCIVCGGHRPSPV------GKMIYCDLCPRAYHADCYIPPLLKVPRGKW 2736
                   |::| .:...|.|     .||:      |..|:|...|:..|.:...|    ||
Mouse   792 -------VSQAQMSSSSCPV-----NSPIMPPGSQGSHIHCPTLPQQAHQNSPSP----VP---- 836

  Fly  2737 YCHGCISRAPPPKKR--SAGGTSGSSSKSRRDRDRESGGSAKRRSDNSKTPAMEHMQQQQMPLA- 2798
                  ||.|.|...  |.|                          |...||.........|.|
Mouse   837 ------SRTPTPHHTPPSIG--------------------------NQPPPATAIPTPVPTPPAI 869

  Fly  2799 --GGDSHHHHHQQPPSLNSSHDESMNSLPAAPLSPAHSVVSATNYDDQHHANNSVDGSSRFHAHL 2861
              |        .|||||:.|..::       |..|.|
Mouse   870 PPG--------PQPPSLHPSSRQT-------PTPPTH---------------------------- 891

  Fly  2862 IPPSNNGTAALLEDVPGGANVMPGVYPVYTPVAAGNFSAGLINQAPVQPAMPFANVVAMSPRAVT 2926
            :||                .|.|.:                       ||.|.|:.....||:..
Mouse   892 LPP----------------QVQPSL-----------------------PAAPSADQSQQQPRSQQ 917

  Fly  2927 PTRTRTPTPTPAPTPPPPPPTPLLMQA---------SPTATALHVNACQSPPQQQHAQLMTMPS- 2981
            .|....|||| ||..||.|.|||...|         .|:.::..||: |:.|::|.:|.:.|.|
Mouse   918 STAVSVPTPT-APLLPPQPSTPLSQPAVSIEGQVSNPPSTSSTEVNS-QTIPEKQPSQEVKMESK 980

  Fly  2982 ------PPAIGVGTATNQMSPPPINIH--AIQEAKEKLKQEKKEK----------------HATK 3022
                  .||......|.:.....:.:.  .::|...:||.:.||:                .:.|
Mouse   981 MEVDKPEPADAQPEDTKEAKGEDVKVEPTEMEERGPELKTDGKEEEEQPSTSATQSSPAPGQSKK 1045

  Fly  3023 KLMKELAVCKTLLGEMEL----HEDSWPFLLPVNTK--QFPTYRKIIKTPMDLSTIKKKLQDLSY 3081
            |:.|...:.:.|:..:|.    ..:|.||..||:.:  ..|.|..|:|:||||||||:||....|
Mouse  1046 KIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKSPMDLSTIKRKLDTGQY 1110

  Fly  3082 KTREDFCVDVRQIFDNCEMFNEDDSPVGKAGHGMRKFFE 3120
            :....:..|:..:|:|..::|...|.|.|....:.:.||
Mouse  1111 QEPWQYIDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVFE 1149

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tou	NP_001097270.1	HAT_MBD	953..1027	CDD:238691
		ZapA	1021..1127	CDD:294720
		MAP7	1043..1198	CDD:283355
		RILP-like	1085..>1179	CDD:304877
		DDT	1255..1317	CDD:280886
		WHIM1	1406..1455	CDD:292246
		WHIM3	2190..2224	CDD:292248
		PHD_BAZ2A_like	2640..2685	CDD:277020	7/44 (16%)
		RanBP2-type Zn finger	2640..2659	CDD:275375	5/18 (28%)
		RanBP2-type Zn finger	2680..2698	CDD:275376	3/18 (17%)
		PHD	2695..2744	CDD:279022	12/54 (22%)
		Bromo_BAZ2A_B_like	3027..3123	CDD:99935	31/100 (31%)
Ep300	XP_006521152.1	KIX	567..647	CDD:366953	17/88 (19%)
		PABP-1234	<714..848	CDD:130689	42/192 (22%)
		Merozoite_SPAM	959..>1048	CDD:284533	18/89 (20%)
		Bromo_cbp_like	1050..1157	CDD:99927	31/100 (31%)
		RING_CBP-p300	1169..1251	CDD:276805
		PHD_p300	1252..1286	CDD:277116
		HAT_KAT11	1315..>1526	CDD:369758
		ZZ_CBP	1677..1717	CDD:239077
		ZnF_TAZ	1738..1816	CDD:214717
		Med15	1968..>2344	CDD:312941
		Creb_binding	2016..2109	CDD:370251
		Med15	88..>328	CDD:312941
		zf-TAZ	348..415	CDD:366931	5/27 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900