Protein Alignment tou and bptf

DIOPT Version :10

• Sequence 1: NP_001097270.1
• Gene: tou / 36241
• FlyBaseID: FBgn0033636
• Length: 3131
• Species: Drosophila melanogaster
• Sequence 2: XP_009297692.1
• Gene: bptf / 324479
• ZFINID: ZDB-GENE-030131-3200
• Length: 2900
• Species: Danio rerio
• Alignment Length: 2906
• Identity: 512/2906 - (17%)
• Similarity: 836/2906 - (28%)
• Gaps: 1236/2906 - (42%)

  Fly   904 QQGADIEKI-RLALSEA-NAHMETSTDSESVAAESGLS-----------------ESESEDANI- 948
            :|.|::|:: |.|..|| .|.:|..|.|:..|:...:|                 |..|.||::
Zfish   519 KQEAELEEVKRRAAEEAERAKLEPKTLSDEPASGDQMSSNDSCPQQDSSNGNARNEQTSSDASVS 583

  Fly   949 -LNVAEL---RVPLELGWKRETVIRGLTK---------------QGQIRGEVT---YYAPGSTTP 991
             :.|.|:   .|| |:.....:.::  ||               .|:.:||.|   ....|.::.
Zfish   584 AVPVGEVLSSSVP-EIAASSSSTVQ--TKPDSQSPIGNAVTSSSSGEEKGEGTDGVEELTGKSSE 645

  Fly   992 LKSNGQVFAILEQQPSNLSREN-----FSFSARAIVGSFLQPAPPPYANDGEYIRMTDE-DVAKR 1050
            ...:|:..::||.:.:..:.||     ||.|                    |.:|..|| |:..|
Zfish   646 GACHGEGDSVLEAELAQTADENSCSSHFSIS--------------------ECLRGPDEPDLVDR 690

  Fly  1051 LEDLKVFTRQTLNVEQRIEIAKQQQAMRDAKKLQKEEL---ARNKEKARQEKNSKLEQQR--KDK 1110
                  .::.:||.:......|   |..|:.|.....:   .||.:       |||.|::  :||
Zfish   691 ------SSQSSLNSQDDTGDGK---ANGDSTKTASSRMITRLRNPD-------SKLSQRKVMQDK 739

  Fly  1111 ELKNQQAVEERKKRQEELDRLKQEELLKKQQEKE----KRRQEAILAKEQELQKQKEMLLAAEME 1171
            :..:|    :..:..:|...|......|:...|.    |..||...
Zfish   740 DGSSQ----DGSRALKETPPLSSFGTFKRDSSKSSGFFKLGQEGKF------------------- 781

  Fly  1172 RERRRQHMSLIRMLELRRKFEDREKKKHQLVLDRLLLRERRMAERKRDAEI-------LQLIRRP 1229
            |....|:.:....|...:..||.:|::|  :..:|.:..  ..|.|.:..:       :..:|
Zfish   782 RVYHNQYSTNTLALNKHQHREDHDKRRH--LSHKLCMTP--AGEFKWNGSLYGSKALTVSTLR-- 840

  Fly  1230 NEDSEMPQELVIPELDRIAGNRLPGQAMADLLMVFEFLH-NFGETLGFDMESLPSLQNLHDALMS 1293
                     |.|.:|:    |.:|.          .||| |:..          ...|...|:..
Zfish   841 ---------LTIIQLE----NNIPA----------PFLHPNWAS----------HRSNWIKAVQM 872

  Fly  1294 DSNADAEEELLSVMTHLLVCAIEDPGVPNPGRHTTLLGQSLRNADITNSNVSEILRIYLYATATG 1358
            .|.  |.|..|::.  :|.|||:                             .::.:.::..:.|
Zfish   873 CSK--AREFALALA--ILECAIK-----------------------------PVVMLPVWKDSLG 904

  Fly  1359 EVRQMHGIT-VDRE-------RERRVPDHHQLDSDTTTH-----SHSV---KNQEYYKLLHENDT 1407
            ..| :|.:| |:||       ||:::.|...:...|...     .|.|   |.:||....:...:
Zfish   905 HTR-LHRMTSVEREEKEKVKKREKKLEDEETMQQATWVKYTFPIKHQVWKQKGEEYRVTGYGGWS 968

  Fly  1408 WKLSQSLKDRPFVALNPT-----RKAQMLAHLCNDLLMNKAVLRQIDGSLETCAQMRKEKYMTDM 1467
            | :|::...|.|..|...     |||...|....|   |:|.|   .|:.:|.  ::|::
Zfish   969 W-VSKTHVHRFFTKLPGNTNVNYRKALEAAKTGMD---NQAAL---PGAPKTV--VKKDE----- 1019

  Fly  1468 KVRKYKALHMRKARIEAYERAQAEREAAMQALMAQQKLDAER---LKAE---EEAKAAAAEEAAA 1526
                     |....:...:.||     .:....:::||..|:   ||.|   ||......||...
Zfish  1020 ---------MSSQNVPDKDNAQ-----VLSLDSSEEKLSVEKDHVLKVEEQDEEKMNETTEEKCN 1070

  Fly  1527 AAGTDGEATKGGSPNG-------------------EKPEDGDQNEEGAAKEPQQ----------- 1561
            ......|.....|||.                   |:|.|.:..::....:|||
Zfish  1071 EKNESVEEMDTSSPNSANEGKVEITNASTDDSTMKEEPLDSEVVKDNTLNQPQQCFWHDVVNVSE 1135

  Fly  1562 --------QQQQPMEVDGV---------------VDEASLVSPAKTIIQT---DNSLTPSKQDMP 1600
                    ::.:|.::||:               :|:......:|.:.:|   :...|.:.||..
Zfish  1136 GFLQRTAYKKLKPSKLDGLLERRVKQFTIEEKQRIDKLKQAPTSKPLTETAVENKETTLAAQDHK 1200

  Fly  1601 TPTYQING--SSTP---TTSGVT----GGDMNVLL---------QAK--KSGARNSINDEHHHDV 1645
            .   :|.|  |.||   .|.||.    ....||:.         |||  .||.:|::      ||
Zfish  1201 V---KIEGTISETPKARQTEGVACLAIQEKDNVVKRLVFNQEDEQAKTNTSGQKNTL------DV 1256

  Fly  1646 SIIDD-DLSDLDSEITNVEEDED--NRLSADEL---QKKLDKIVRASLNCKEALEKSTNQLRAAC 1704
            .:.|. :|:..:::....|.|..  :|::..||   .:.||:.:  |||.|    ...|...|.|
Zfish  1257 RLNDSVELAPKENQQKLAETDPKTASRVAMSELNGNSQSLDQSL--SLNAK----PDKNITEATC 1315

  Fly  1705 FGQDRFWRRYWKLPKAGGIFIEALESAQNDICDYHEALEAMDDKKDANDEKE------NSENE-- 1761
            ..:|          .||.   :.:|:::||: |..:.:....:.||...:.|      |.:.:
Zfish  1316 PPED----------SAGK---DNIENSENDL-DVKKTVPVQVNGKDVTVDPECKNLTDNGDTKEL 1366

  Fly  1762 -----KDVAAESSEQPMEVDESITKLEDGVPASDVGMPESNQQNAHQDEEDDDDDVTEI------ 1815
                 :|:.|.|.::|      :..|.:| .|:...:.|.......|...|::..||::
Zfish  1367 TNTIVEDIKAISPKEP------VKSLMNG-DATQECLKEWTNSTIPQVNLDEEKAVTKLDPDYPP 1424

  Fly  1816 --------NKVEPEIVDLGDDDDDAAPPLPKIEPPRPEIKVKSEMELMGPPPTTMISTKTDFEAE 1872
                    |.:|..|      |...:..:|:..|...|...:||:    |..::.:......||:
Zfish  1425 PQKVAKLENNIEKPI------DSSVSLSVPEPSPVASEPNERSEV----PSHSSKVEPMQVVEAK 1479

  Fly  1873 IKIPSMPGILMPPTLNNNNTNNNNNNNGSDNCDKLETGLGLGQQQQNFSQSVIKTEDVKKEDDCI 1937
            ..:||........:|:::.|.|:::               :|:... .:|....|..|..|...:
Zfish  1480 PSVPSPVPSAEESSLSSDLTENSSS---------------IGETTV-VTQVTTTTTTVSTESRMV 1528

  Fly  1938 IVSTSSVDDTPKWFSIVRREVPLISELPAEEGGV---------VGQELQISYANQNCSAQLQLQG 1993
            :.|..|:                     |.:.|:         |.....:|..:...:..:.
Zfish  1529 LTSRDSL---------------------ASKNGLNTAVLTDSKVESSSSVSTLSSTTTTTVT--- 1569

  Fly  1994 HPWDLINNMQYYSIPMDECKVDTSKLGNECIFSLSGLDEKQMLAKVEEYKAHKVESKNGLGSPHR 2058
               .::::.|..:: ..|||....|...:...|.||...|.|....|
Zfish  1570 ---KVLSSSQEATL-TTECKTMVMKTLTDTTSSPSGSTVKSMTVSHE------------------ 1612

  Fly  2059 HHETKDDEEQAKLKLDKEIDTEMETDADDLAGKEKFFRLRSD-----VPPD------TGGGVSE- 2111
             :.|:|     :::|.|...|:.......|....||....|.     :|.|      ..||:.|
Zfish  1613 -YSTRD-----RVRLLKFSRTKKTRSGTALPSYRKFVTKSSKKSIFVLPNDELKKLARRGGIREV 1671

  Fly  2112 ---GTDVKPKIELRLDEALSQAYYHNIANMSLSSVQTYIPIDIPLPLSMTPDEHRLLEQVKLAGF 2173
               ..:.||.:::                         .|...|.|.......:||.....|||
Zfish  1672 PIFNYNAKPALDI-------------------------WPYPSPRPTFGITWRYRLQTVRSLAG- 1710

  Fly  2174 PERVHGVYVPRRQRYGW----WQ-----------------LDDEQKLRQLLK--TLNPSGLRERE 2215
                    |....|..|    |.                 .|.:....:::|  .:.|.|:|.
Zfish  1711 --------VSLMLRLLWACLRWDDMSVKPSPTGGTTRTETSDTDITTTEIIKRRDVGPYGIRS-- 1765

  Fly  2216 LQENLQRFLGLEQPLGVNYKLKSDIDFPEEFLMPDKKG-------DWNPKVAKRVELALIEQLES 2273
             :..:::.:   .||||.       :.|:|...|.:||       ...|:.||:....:||...:
Zfish  1766 -EYCIRKII---CPLGVP-------ETPKETPTPQRKGLRSSALRPKKPEPAKQTGPVVIETWVA 1819

  Fly  2274 LEDKVASASMQLKNWQL---PNRVESELTLDSQEDVTEEDFVSIIPMIRERIIDLEANIERRYL- 2334
            .||        |:.|::   ..|||.|     :....:...||:.....|....|||.::::.|
Zfish  1820 EED--------LELWEIRAFTERVERE-----KAQAADPTKVSVQKKAEEVKAQLEAQLKQQRLA 1871

  Fly  2335 ---------KPPLGSQTGDAHLAVIAQNQHTTTQ-------------------TQNSASAAAYLL 2371
                     ||...|.|  ..|........||||                   |....|...:
Zfish  1872 AQQKRLEQQKPSTTSNT--TTLTSTPTTPGTTTQKVVVGSISGQVTSTPKVVMTTKLGSPVTF-- 1932

  Fly  2372 QMQQQQQQQQLAQQQQQQQQGSGAGNSLNPSSFNERTMALAAAAA---------ASGPGNATG-- 2425
             .|.:..||..|...:|.||    |||::.||    .:.:||::|         |:.||:..|
Zfish  1933 -QQNKNFQQSFASWVKQGQQ----GNSVSTSS----VVTVAASSATTSGQTFHIAAAPGSMAGSV 1988

  Fly  2426 -------VANSAVVAGATPCESGSGEPNSGNASPASNCDSDRDEKVEQIPKGLVQWRDAVSRSHT 2483
                   .|||.:|....|...|                            ||||.:..|
Zfish  1989 IAAKLPVPANSKIVTVNVPTTQG----------------------------GLVQVQQKV----- 2020

  Fly  2484 TAQLAMALYVLESCVAWDKSIMKAYATKNKSSKKKSSAKKQATPSKKQQQKKNKKEQQLTPNGKE 2548
                   :.::.|..|.:......:..:..:    .:.:...|.|         .:|.||.....
Zfish  2021 -------VGIIPSSTAGNAQSFPPFQPRTAT----INIRPNTTTS---------TQQVLTTGTTL 2065

  Fly  2549 SKSKSAINKPENQAPLSIK--INLKALAQNGQCLLKTK---------TPPILTKSPTASPSSHPN 2602
            ....:.|..|..||....|  |....:.|.||...:.:         |||.|   ||.:....|.
Zfish  2066 RPGMTVIRSPLQQATTLGKTIIRTPLMVQQGQTQQQVQTSSGTQVVGTPPRL---PTPNQPQTPQ 2127

  Fly  2603 TSDSDSDFGKRTKKKSGGKRRRSANNTNSSKYSNSLQNCQFCTSGENEDKLLLCDGCDKGYHTYC 2667
            |..|       .:.:.|..:...|..|..:      |..|    |.|:...::..|  :|..|
Zfish  2128 TPAS-------PRPQQGQVKLTLAQLTQLT------QGAQ----GGNQGLTVVIQG--QGQTT-- 2171

  Fly  2668 FKPKMDNIPDGDWYCYECVNKATNERKCIVCGGHRPSPVGKMIYCDLCPRAYHADCYIPPLLKVP 2732
              .::..||.|               ..::     |.| |:.:.....|..........|:...|
Zfish  2172 --GQLQVIPQG---------------VTVI-----PGP-GQQLMQAAMPNGQVQRFLFTPMAPAP 2213

  Fly  2733 RGKWYCHGCISRAPPPKKRSAGGTSGSSSKSRRDRDRESGGSAKRRSDNSKTPAMEHMQQQQMPL 2797
                        .|.|...||.....:::.|      ....:|...:..|.|||......:..|
Zfish  2214 ------------TPAPAPVSAPAAPSNTTPS------SVPPAAAPTAVTSTTPAPIQTAARLAP- 2259

  Fly  2798 AGGDSHHHHHQQPPSLNSSHDESMNSLPAAPLSPAHSVVSATNYDDQHHANNSVDGSSRFHAHLI 2862
                     ..|||             |:.|..|:                             :
Zfish  2260 ---------QPQPP-------------PSLPPPPS-----------------------------V 2273

  Fly  2863 PPSNNGTAALLEDVPGGANVMPGVYPVYTPVAAGNFSAGLINQAPVQPAMPFANVVAMSPRAVTP 2927
            |||..     ::..|  |.:...|.|..||              |:||..|    |.:.|:...|
Zfish  2274 PPSQP-----VQHTP--APIQTAVIPQPTP--------------PIQPHPP----VQLRPQPQLP 2313

  Fly  2928 TRTRTPTPTPAPTP--------PPPPPTPLLMQASPTATALHVNACQSPPQ-------------- 2970
            .:.....|||..||        .||.....|.....|.|.:... .|.|||
Zfish  2314 PQNPVVPPTPVSTPQIAQVTATAPPQQITTLPVTQTTVTKVQPQ-IQLPPQLLSVPGLQQQVLSH 2377

  Fly  2971 -------QQHAQLMT---MPSPPAIGVGTATNQMSPPPINIHAI--------------------- 3004
                   |..||:.|   ||....:.:.....|.....:..|.|
Zfish  2378 IQSQVAAQIQAQVGTTAGMPQQIKLQLPIQIQQQGGGQVQAHQIQNLVTIQTASVQEQLQRIQQL 2442

  Fly  3005 ----------QEAK--------------------------EKLKQ-------------------- 3013
                      ||||                          |:|||
Zfish  2443 CEQQQQKKKQQEAKREQAQQHVSQSDLIQKQVAQKQNVAIEQLKQKKTMTPAEREENQRMIVCNQ 2507

  Fly  3014 ---------EKKEKHATKK----------------------------------------LMKEL- 3028
                     :|.|:.|.||                                        |.|||
Zfish  2508 VMKFILDKIDKDERQAAKKRKREESVEQKRSKQNASKLSALLFKHKEQLKADILKKRALLDKELQ 2572

  Fly  3029 ----------------------------------------------------------------- 3028
                                                                             
Zfish  2573 LQVQEELKRDLIKLRREKEKAQAAAAQAAAAAAAAAAASTHVHSGLSSYTGTVTSPTSTHKRKRE 2637

  Fly  3029 ----------------------------AVCKT-------------------------------- 3033
                                        .:|||
Zfish  2638 EERDAAKPKRKKMISTTSKDSKRDIKLYCICKTPYDESKFYIGCDLCSNWYHGECVGITEKEAKK 2702

  Fly  3034 ----------------------------------------------------------------- 3033
                                                                             
Zfish  2703 MDDYICSECKRAQEGNTEELYCICRTPYDESQFYIGCDRCQNWYHGRCVGILQSEATHIDEYVCP 2767

  Fly  3034 -------------------------LLGEMELHEDSWPFLLPVNTKQFPTYRKIIKTPMDLSTIK 3073
                                     :|..::.|:.:||||.||:....|.|..|||.||||||::
Zfish  2768 QCQSTEDAMTVLTPLTDKDYEGLKRILRSLQSHKMAWPFLEPVDPNDAPDYYGIIKEPMDLSTME 2832

  Fly  3074 KKLQDLSYKTREDFCVDVRQIFDNCEMFNEDDSPVGKAGHGMRKFF 3119
            :::|...|....:|..|:.:|||||..:|..|||..:....:..||
Zfish  2833 ERIQKRFYSKLTEFVADMTKIFDNCRYYNPSDSPFYQCAEFLESFF 2878

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tou	NP_001097270.1	HAT_MBD	953..1027	CDD:238691	19/99 (19%)
		TPH	<1041..1228	CDD:464007	37/203 (18%)
		PTZ00121	<1045..1681	CDD:173412	145/762 (19%)
		DDT	1255..1317	CDD:460696	14/62 (23%)
		WSD	1700..>1726	CDD:464775	5/25 (20%)
		WSD	<2173..2222	CDD:464775	9/71 (13%)
		PHD_BAZ2A_like	2640..2685	CDD:277020	9/44 (20%)
		RanBP2-type Zn finger	2680..2698	CDD:275376	0/17 (0%)
		PHD	2695..2741	CDD:214584	6/45 (13%)
		Bromo_BAZ2A_B_like	3027..3123	CDD:99935	39/309 (13%)
bptf	XP_009297692.1	DDT	198..254	CDD:460696
		PHD1_BPTF	349..391	CDD:277034
		WSD	413..478	CDD:464775
		PHA03247	<1978..2187	CDD:223021	54/307 (18%)
		Amelin	<2320..>2390	CDD:214832	16/70 (23%)
		tolA_full	2425..>2599	CDD:274303	17/173 (10%)
		PHD2_3_BPTF	2665..2711	CDD:277035	3/45 (7%)
		PHD2_3_BPTF	2723..2769	CDD:277035	0/45 (0%)
		Bromo_gcn5_like	2785..2885	CDD:99941	34/94 (36%)