DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tou and Brd8

DIOPT Version :9

Sequence 1:	NP_001097270.1	Gene:	tou / 36241	FlyBaseID:	FBgn0033636	Length:	3131	Species:	Drosophila melanogaster
Sequence 2:	XP_008770251.2	Gene:	Brd8 / 291691	RGDID:	1307003	Length:	1206	Species:	Rattus norvegicus

Alignment Length:	1518	Identity:	267/1518 - (17%)
Similarity:	466/1518 - (30%)	Gaps:	564/1518 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1738 YHEALEAMDDKKDANDEK-ENSENEKDV-----AAESSEQ----PMEVDESITKLEDGVPASDVG 1792
            |.|.||..:..|....|| |..|..:||     .||..|:    ..|..|...:|:........|
  Rat    68 YSELLETTETPKRKRGEKGEVVETVEDVIVRKLTAERVEELKKVIKETQERYRRLKRDAELIQAG 132

  Fly  1793 MPESNQQNAHQDEEDDD--DDVTEINKVEPEIVDLGDDDDDAAPPLPKI--EPPR--PEIKVKSE 1851
                     |.|...|:  .|:....|:|.|..::.....|||....:.  .|||  |.:.|:|.
  Rat   133 ---------HMDSRLDELCSDIAMKKKLEEEEAEVKRKATDAAYQARQAVKTPPRRLPTVMVRSP 188

  Fly  1852 MELMGP---------PPTTMISTKTDFE----AEIKIPSMPGILMPPTLNNNNTNNNNNNNGSDN 1903
            ::...|         .||||....:...    ....:.|.|||  |.||...:.
  Rat   189 IDSASPGGDYPLGDLTPTTMEEATSGVTPGTLPSTPVTSFPGI--PDTLPPGSA----------- 240

  Fly  1904 CDKLETGLGLGQQQQNFSQSVIKTEDVKKEDDCIIVSTSSVDDTPKWFSIVRREV----PLISE- 1963
              .||..:                             |...||:|:...:.::..    ||:||
  Rat   241 --PLEAPM-----------------------------TPVTDDSPQKKMLGQKATPPPSPLLSEL 274

  Fly  1964 ------LPAEEGGVVGQELQISYAN-QNCSAQLQLQGHPWDLINNMQYYSIPMDECKVDTSKLGN 2021
                  ||.....|...|:.:...: .:....|::.|            .:||
  Rat   275 LKKGSLLPTSPRLVNESEMPVPSGHLSSTGVLLEVGG------------VLPM------------ 315

  Fly  2022 ECIFSLSGLDEKQMLAKVEEYKAHKVESKNGLGSPHRHHETKDDEEQAKLKLDKEIDTEMETDAD 2086
                 :.|.|.:...:.|       ..|....|:|               .|.:.::
  Rat   316 -----IHGGDIQPATSAV-------AASPAASGAP---------------TLSRLLE-------- 345

  Fly  2087 DLAGKEKF------FRLRSDVPPDTGGGVSEGTDVK---PKIELRLDEALSQAYYHNIANM---- 2138
              ||..:|      |...:..||           ||   |.:     |::|||   .|..|
  Rat   346 --AGPTQFSTPLPSFTTVASEPP-----------VKLVPPPV-----ESVSQA---TIVMMPALP 389

  Fly  2139 ------SLSSVQTYIPIDIPLP--------------LSMTPDE-----HRLLEQVKLAGFPERVH 2178
                  ::|:.::..|:..|.|              :||...|     :.:.|:...:|..|...
  Rat   390 APSSAPAVSTPESVAPVSQPEPCVPLEAVGDPQTVTVSMDSSEISMIINSIKEECFRSGVAEAPG 454

  Fly  2179 GVYVPRRQRYGWWQLDDEQKLRQLLKTLNPSGLRERELQENLQRFLGLEQPLGVNYKLKSDIDFP 2243
            |...|        .:|.::.|               :|.|.:.        :.|:| ...::||.
  Rat   455 GSKAP--------SIDGKEDL---------------DLAEKMD--------IAVSY-TGEELDFE 487

  Fly  2244 ---EEFLMPDKKGDWNPKVAKRVELALIEQLESLEDKVASASMQLKNWQLPNRVE---------S 2296
               :...:.:.|.|.:|:|   :::|.:|...|..::..........|:.|.:.|         .
  Rat   488 TVGDIIAIIEDKVDDHPEV---LDVAAVEAALSFCEENDDPQSLPGPWEHPIQQERDKPVPLPAP 549

  Fly  2297 ELTLDSQE-DVTEEDFVSIIPMIRERIIDLEANIERRYLKPPLGSQTGDAHLAVIAQNQHTTTQT 2360
            |:|:..:. |..|.:...|..::..|...:|..:|      |...:.|.:...::|
  Rat   550 EMTVKQERLDFEESETKGIHELVDIRDSGVEIKVE------PTEPEPGMSGAEIVA--------- 599

  Fly  2361 QNSASAAAYLLQMQQQQQQQQLAQQQQQQQQGSGAGNSLNPSSFNERTMALAAAAAASGP-GNAT 2424
                                           |.|...||.|.....:.:.....::|:|. |.|.
  Rat   600 -------------------------------GVGPVPSLEPPELRSQDLDEEPRSSAAGEMGEAD 633

  Fly  2425 GVANSAVVAGATPCESGSGEPNSGNASPASNCDSDRDEKVEQIPKGLVQWRDAVSRSHTTAQLAM 2489
            |             .||.||.   ...||        .|.|..|:.:      :|.||.:..:..
  Rat   634 G-------------SSGKGEE---RPLPA--------VKTEASPESM------LSPSHGSNPIED 668

  Fly  2490 ALYVLESCVAWDKSIMKAYATKNKSSKKKSSAKKQAT---------PSKKQQQKKNKKEQQLTPN 2545
            .|..               .|::|.....|..::..|         |.:::::....:...|...
  Rat   669 PLEA---------------ETQHKFEMSDSLKEESGTIFGSQIKDAPGEEEEEDGVSEAASLEEP 718

  Fly  2546 GKESKSKSAINKPENQAPLSIKINLKALAQNG----QCLLKTKTPPILTKSPTASPSSHP---NT 2603
            .:|.:.:..:::.:|:.|:|       .:.:|    ...|::.|   |..|..:||:|..   .:
  Rat   719 KEEDQGEGYLSEMDNEPPVS-------ESDDGFSIHNATLQSHT---LGDSIPSSPASSQFSVCS 773

  Fly  2604 SDSDSDFGKRTKKKSGGKRRRSANNTNSSKYSN-SLQNCQFCTSGENEDKLLLCDGCDKGYHTYC 2667
            .|.::...::..||:.....|:|.|   .:|:| .||.              :.|....|||:..
  Rat   774 EDQEAIQAQKIWKKAIMLVWRAAAN---HRYANVFLQP--------------VTDDIAPGYHSIV 821

  Fly  2668 FKPKMD------NIPDGDWYCYECVNKATNE--RKCIVCGGHRPSPVGKMIYCDLCPRAYHADCY 2724
            .:| ||      ||.:|       :.::|.|  |..::...:      .::|.......||....
  Rat   822 QRP-MDLSTIKKNIENG-------LIRSTAEFQRDIMLMFQN------AVMYNSSDHDVYHMAVE 872

  Fly  2725 IPPLLKVPRGKWYCHGCISRAPPPKKRSAGGTSGSSSKSRRDRDRESGGSAKRRSDNSKTPAMEH 2789
            :...:.....::.....|.:.         ..||.|:||.|.||      :.|:.|.|
  Rat   873 MQRDVLEQIQQFLATQLIMQT---------SESGISAKSLRGRD------STRKQDAS------- 915

  Fly  2790 MQQQQMPLAGG---------------DSHHHHHQQPP------SLNSSHDESMNSLPAAPLSPAH 2833
             ::..:|:...               ||...:.....      ||.||.|.|::
  Rat   916 -EKDSVPMGSPAFLLSLFVGCEWVWLDSGQDYPDDSELSNDCRSLFSSWDSSLD----------- 968

  Fly  2834 SVVSATNYDDQHHAN---NSVDGSSRFHAHLIPPSNNGTAALLEDVPGGANVMPGVYPVYTPVAA 2895
              :...::.|...|:   :.::.||        |....:..|::|:..|           .|...
  Rat   969 --LDVGSWKDSEDADVEADELEESS--------PERESSELLVDDMESG-----------EPQEE 1012

  Fly  2896 GNFSAGLINQAPVQPAMPFANVVAMSPRAVTPTRTRTPTPTPAPTPPPPPPTPLLMQASPTATAL 2960
            .:....|::....:.|                                      |..:..|.
  Rat  1013 QDTQQNLLHLLSEEEA--------------------------------------LQDSKETG--- 1036

  Fly  2961 HVNACQSPPQQQHAQLMTMPSPPAIGVGTATNQMSPPPI-----NIHAIQEAKEKLKQEKKEKHA 3020
                      |...........|.:|.|....::...|:     |.....:..:..:.:..:.|.
  Rat  1037 ----------QGEGDASDGEDTPPLGEGRDGVRVQEAPLVNILYNCSNSSQLSDLSQGDPTQDHF 1091

  Fly  3021 TKKLMKELAVCKTLLGEMEL---HEDSWPFLLPVNTKQFPTYRKIIKTPMDLSTIKKKLQDLSYK 3082
            ..|        ||||...::   |..|.|||.||:.||.|.|:.::|.||||:|:|:.|......
  Rat  1092 LFK--------KTLLQVWKMIASHRFSSPFLKPVSEKQAPGYKDVVKRPMDLTTLKRNLSKGRIH 1148

  Fly  3083 TREDFCVDVRQIFDNCEMFNEDD 3105
            |..:|..|:..:|.|..|:|:.|
  Rat  1149 TMAEFQRDLMLMFQNAVMYNDSD 1171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tou	NP_001097270.1	HAT_MBD	953..1027	CDD:238691
		ZapA	1021..1127	CDD:294720
		MAP7	1043..1198	CDD:283355
		RILP-like	1085..>1179	CDD:304877
		DDT	1255..1317	CDD:280886
		WHIM1	1406..1455	CDD:292246
		WHIM3	2190..2224	CDD:292248	4/33 (12%)
		PHD_BAZ2A_like	2640..2685	CDD:277020	10/50 (20%)
		RanBP2-type Zn finger	2640..2659	CDD:275375	1/18 (6%)
		RanBP2-type Zn finger	2680..2698	CDD:275376	3/19 (16%)
		PHD	2695..2744	CDD:279022	4/48 (8%)
		Bromo_BAZ2A_B_like	3027..3123	CDD:99935	31/82 (38%)
Brd8	XP_008770251.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900