DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tou and KAT2A

DIOPT Version :9

Sequence 1:	NP_001097270.1	Gene:	tou / 36241	FlyBaseID:	FBgn0033636	Length:	3131	Species:	Drosophila melanogaster
Sequence 2:	NP_001363156.1	Gene:	KAT2A / 2648	HGNCID:	4201	Length:	838	Species:	Homo sapiens

Alignment Length:	898	Identity:	189/898 - (21%)
Similarity:	288/898 - (32%)	Gaps:	275/898 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  2413 AAAAASGPGNATGVANSAVVAGATPCESGSGEPNSGNASPASNCDSDRDEKVEQIPKGLVQWRDA 2477
            |:|....|..|...|.:|..||:|    |:|.|..|:....|..|..|        .||.|.:.|
Human    35 ASAPIPTPTPAPAPAPAAAPAGST----GTGGPGVGSGGAGSGGDPAR--------PGLSQQQRA 87

  Fly  2478 VSRSHTTAQLAMA-----LYVLESCVAWDKSIMKAYATKNKSSKKKSSAKKQ--ATPSKKQQQKK 2535
            ..|......|..|     |.|..:|.|  ....|....||   .|..:|.:.  ..|:....:..
Human    88 SQRKAQVRGLPRAKKLEKLGVFSACKA--NETCKCNGWKN---PKPPTAPRMDLQQPAANLSELC 147

  Fly  2536 NKKEQQLTPNGK--ESKSKSAIN-----------------KPENQAPLSIKINLKALAQNGQCLL 2581
            ...|..|..:..  |:.|:..||                 |.|:.....:...|..|.:  :|:|
Human   148 RSCEHPLADHVSHLENVSEDEINRLLGMVVDVENLFMSVHKEEDTDTKQVYFYLFKLLR--KCIL 210

  Fly  2582 KTKTPPILTKSPTASPSSHPNTSDSDSDFGKRTKKKSGGKRRRSANNTNSS-----KYSNSLQNC 2641
            : .|.|::..|..:.|...||......:|.:........:.|::....:..     .|.......
Human   211 Q-MTRPVVEGSLGSPPFEKPNIEQGVLNFVQYKFSHLAPRERQTMFELSKMFLLCLNYWKLETPA 274

  Fly  2642 QFCTSGENEDKLL--------LCDGCDKGYHTYCFKPK-MDNIPDGDWYCYECV----------- 2686
            ||....:.||...        ||         ||..|: .|::|.     ||..
Human   275 QFRQRSQAEDVATYKVNYTRWLC---------YCHVPQSCDSLPR-----YETTHVFGRSLLRSI 325

  Fly  2687 ----------------NKATNERKCIVCGGHRP---SPVGKMIYCDLCPRAYHADCYIPP---LL 2729
                            :|...|::.::. .|.|   |.:.:.||....| .:.:...:||   ..
Human   326 FTVTRRQLLEKFRVEKDKLVPEKRTLIL-THFPKFLSMLEEEIYGANSP-IWESGFTMPPSEGTQ 388

  Fly  2730 KVPRGKWYCHGCISRAPPPK----KRSAGGTSGSSSKSRRDRDRESGGSAKRRSDNSKTPAMEHM 2790
            .|||     ...:|.|..|.    ..|.||.|.||      ...:|.|:.....:....|....:
Human   389 LVPR-----PASVSAAVVPSTPIFSPSMGGGSNSS------LSLDSAGAEPMPGEKRTLPENLTL 442

  Fly  2791 QQQQMPLAGGDSHHHHHQQPPSLNSSHDESMNSL--PAAPLSPAHSVVSATNYDDQHHANNSVDG 2853
            :..:.....||.       |..|   .:|.|.::  |||.|.|..|::||....|:........|
Human   443 EDAKRLRVMGDI-------PMEL---VNEVMLTITDPAAMLGPETSLLSANAARDETARLEERRG 497

  Fly  2854 SSRFHA---HLIPPSNNGTAALLEDVPGGANV-------MPGVY---PVYTP-------VAAGNF 2898
            ...||.   .|.|.:|.   .:|..:.|..||       ||..|   .|:.|       :..|..
Human   498 IIEFHVIGNSLTPKANR---RVLLWLVGLQNVFSHQLPRMPKEYIARLVFDPKHKTLALIKDGRV 559

  Fly  2899 SAGLINQAPVQPAMPFANVVAMSPRAVTPTRTRTPTPTPAPTPPPPPPTPLLMQASPTATAL--H 2961
            ..|:..:  :.|...|..:|..   |||...                      |.....|.|  |
Human   560 IGGICFR--MFPTQGFTEIVFC---AVTSNE----------------------QVKGYGTHLMNH 597

  Fly  2962 VNACQSPPQQQHAQ-----LMTMPSPPAIG------------------------------VGTAT 2991
            :       ::.|.:     .:|.....|||                              :....
Human   598 L-------KEYHIKHNILYFLTYADEYAIGYFKKQGFSKDIKVPKSRYLGYIKDYEGATLMECEL 655

  Fly  2992 NQMSPPPINIHAIQEAKE----KLKQEK--------------KE------------------KHA 3020
            |...|.....|.|::.||    ||.:.|              ||                  |..
Human   656 NPRIPYTELSHIIKKQKEVIIKKLIERKQAQIRKVYPGLSCFKEGVRQIPVESVPGIRETGWKPL 720

  Fly  3021 TKKLMKEL-------AVCKTLLGEMELHEDSWPFLLPVNTKQFPTYRKIIKTPMDLSTIKKKLQD 3078
            .|:..|||       ...|.||.:::.|..:|||:.||...:.|.|.::|:.|:||.|:.::|:.
Human   721 GKEKGKELKDPDQLYTTLKNLLAQIKSHPSAWPFMEPVKKSEAPDYYEVIRFPIDLKTMTERLRS 785

  Fly  3079 LSYKTREDFCVDVRQIFDNCEMFNEDDSPVGKAGHGMRKF--FESRWGELTDK 3129
            ..|.||:.|..|::::..||..:|..||...:....:.||  |:.:.|.|.||
Human   786 RYYVTRKLFVADLQRVIANCREYNPPDSEYCRCASALEKFFYFKLKEGGLIDK 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tou	NP_001097270.1	HAT_MBD	953..1027	CDD:238691
		ZapA	1021..1127	CDD:294720
		MAP7	1043..1198	CDD:283355
		RILP-like	1085..>1179	CDD:304877
		DDT	1255..1317	CDD:280886
		WHIM1	1406..1455	CDD:292246
		WHIM3	2190..2224	CDD:292248
		PHD_BAZ2A_like	2640..2685	CDD:277020	12/53 (23%)
		RanBP2-type Zn finger	2640..2659	CDD:275375	6/26 (23%)
		RanBP2-type Zn finger	2680..2698	CDD:275376	4/44 (9%)
		PHD	2695..2744	CDD:279022	11/54 (20%)
		Bromo_BAZ2A_B_like	3027..3123	CDD:99935	32/104 (31%)
KAT2A	NP_001363156.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..99		22/75 (29%)
		PCAF_N	89..335	CDD:368925	47/267 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..434		8/32 (25%)
		COG5076	492..833	CDD:227408	78/377 (21%)
		Acetyl-CoA and acyl-CoA binding. /evidence=ECO:0000269\|PubMed:17410582, ECO:0000269\|PubMed:29211711, ECO:0007744\|PDB:5TRL	579..581		0/4 (0%)
		Acetyl-CoA and acyl-CoA binding. /evidence=ECO:0000269\|PubMed:17410582, ECO:0000269\|PubMed:29211711, ECO:0007744\|PDB:5TRL	586..592		1/5 (20%)
		Acetyl-CoA and acyl-CoA binding. /evidence=ECO:0000269\|PubMed:17410582, ECO:0000269\|PubMed:29211711, ECO:0007744\|PDB:5TRL	617..620		1/2 (50%)
		Loop 3. /evidence=ECO:0000269\|PubMed:29211711	639..648		0/8 (0%)
		Bromo_gcn5_like	733..832	CDD:99941	30/98 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900