DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tou and CHD5

DIOPT Version :9

Sequence 1:	NP_001097270.1	Gene:	tou / 36241	FlyBaseID:	FBgn0033636	Length:	3131	Species:	Drosophila melanogaster
Sequence 2:	NP_056372.1	Gene:	CHD5 / 26038	HGNCID:	16816	Length:	1954	Species:	Homo sapiens

Alignment Length:	579	Identity:	121/579 - (20%)
Similarity:	184/579 - (31%)	Gaps:	198/579 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  2225 GLE--------QPLGVNYKLKSDIDFPEEFLMPDKKGDWNPKVAKRVELALIEQLESLEDKVASA 2281
            |||        :|:.:..|.|     |::......||....|.....||:  |..|.||:|..|.
Human    32 GLEAFDDFFPVEPVSLPKKKK-----PKKLKENKCKGKRKKKEGSNDELS--ENEEDLEEKSESE 89

  Fly  2282 SMQLKNWQLPNRVESELTLDSQEDVTEEDFVSIIPMIRERIIDLEANIERRYLKPP-----LGSQ 2341
            .....    ||:.:.:...|.:|...:          |::..:.|.:.:...||.|     |.::
Human    90 GSDYS----PNKKKKKKLKDKKEKKAK----------RKKKDEDEDDNDDGCLKEPKSSGQLMAE 140

  Fly  2342 TG--DAHLAVIAQNQHTTTQTQNSASAAAYLLQMQQQQQQQQLAQQQQQQQQGSGAGNSLNPSSF 2404
            .|  |.......::.||.|                                         |..:|
Human   141 WGLDDVDYLFSEEDYHTLT-----------------------------------------NYKAF 164

  Fly  2405 NERTMALAAAAAASGPGNATGVANSAVVAGATPCESGSGEPNSGNASPASNCDSDRDEKVEQIPK 2469
            ::....|.|......|     ::....|.||...|..:..|..|:::.|:..
Human   165 SQFLRPLIAKKNPKIP-----MSKMMTVLGAKWREFSANNPFKGSSAAAAAA------------- 211

  Fly  2470 GLVQWRDAVSRSHTTAQLAMALYVLESCVAWDKSIMKAYATKNKSSKKKSSAKKQATPSKKQQQK 2534
                   ||:.:..|..::..|.|....|.....|.||   |.|..|.....||  ....|..:|
Human   212 -------AVAAAVETVTISPPLAVSPPQVPQPVPIRKA---KTKEGKGPGVRKK--IKGSKDGKK 264

  Fly  2535 KNKKEQQLTPNGKESKSKSAINKPENQAPLSIKINLKALAQNGQCLLKTKTPPILTKSPTASPSS 2599
            |.|        ||::..                             ||.:...|..|....|.|.
Human   265 KGK--------GKKTAG-----------------------------LKFRFGGISNKRKKGSSSE 292

  Fly  2600 HPNTSDSDSD----------------FGKRTKKKSGGKRRRSANNTNSSKYSNSLQN-CQFCTSG 2647
            .....:||.|                .||::|     :||:.....:...|....|: |:.|..|
Human   293 EDEREESDFDSASIHSASVRSECSAALGKKSK-----RRRKKKRIDDGDGYETDHQDYCEVCQQG 352

  Fly  2648 ENEDKLLLCDGCDKGYHTYCFKPKMDNIPDGDWYCYECVNKATN-ERK----------------- 2694
               .:::|||.|.:.||..|..|:::..|:|.|.|..|..:... |.|
Human   353 ---GEIILCDTCPRAYHLVCLDPELEKAPEGKWSCPHCEKEGIQWEPKDDDDEEEEGGCEEEEDD 414

  Fly  2695 ----CIVCGGHRPSPVGKMIYCDLCPRAYHADCYIPPLLKVPRGKWYCHGCISRAPPPK 2749
                |.||     ...|:::.||.||.:||..|..|||.::|.|:|.|..|  ..||.|
Human   415 HMEFCRVC-----KDGGELLCCDACPSSYHLHCLNPPLPEIPNGEWLCPRC--TCPPLK 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tou	NP_001097270.1	HAT_MBD	953..1027	CDD:238691
		ZapA	1021..1127	CDD:294720
		MAP7	1043..1198	CDD:283355
		RILP-like	1085..>1179	CDD:304877
		DDT	1255..1317	CDD:280886
		WHIM1	1406..1455	CDD:292246
		WHIM3	2190..2224	CDD:292248
		PHD_BAZ2A_like	2640..2685	CDD:277020	15/45 (33%)
		RanBP2-type Zn finger	2640..2659	CDD:275375	6/19 (32%)
		RanBP2-type Zn finger	2680..2698	CDD:275376	6/39 (15%)
		PHD	2695..2744	CDD:279022	19/48 (40%)
		Bromo_BAZ2A_B_like	3027..3123	CDD:99935
CHD5	NP_056372.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..134		27/122 (22%)
		CHDNT	150..199	CDD:285335	12/94 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	225..338		31/159 (19%)
		Histone-binding	343..653		41/134 (31%)
		PHD1_CHD_II	345..387	CDD:277006	15/44 (34%)
		PHD2_CHD_II	418..460	CDD:277007	18/46 (39%)
		CHROMO	466..546	CDD:214605	1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	549..571
		CHROMO	592..>625	CDD:214605
		SNF2_N	703..999	CDD:278600
		DEXDc	720..878	CDD:238005
		DEAH box	847..850
		Helicase_C	1023..1138	CDD:278689
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1209..1253
		DUF1087	1298..1358	CDD:283996
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1351..1411
		DUF1086	1388..1529	CDD:283992
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1524..1564
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1597..1640
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1658..1696
		CHDCT2	1732..1903	CDD:285336
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0383
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900