Protein Alignment tou and Baz1b

DIOPT Version :10

• Sequence 1: NP_001097270.1
• Gene: tou / 36241
• FlyBaseID: FBgn0033636
• Length: 3131
• Species: Drosophila melanogaster
• Sequence 2: NP_035844.2
• Gene: Baz1b / 22385
• MGIID: 1353499
• Length: 1479
• Species: Mus musculus
• Alignment Length: 2252
• Identity: 357/2252 - (15%)
• Similarity: 655/2252 - (29%)
• Gaps: 1062/2252 - (47%)

  Fly  1043 TDEDVAKRLE--DLKVFTRQTLNVEQ--RIEIAKQQQAMRDAKKLQKEELARNKEK--------- 1094
            |.|:...|||  ..:::|.::....|  ..|..:::|   :..:|.|||.....||
Mouse    34 TREEYEARLERYSERIWTCKSTGSSQLTHKEAWEEEQ---EVAELLKEEFPNWYEKLVLEMVHHN 95

  Fly  1095 -ARQEK---NSKLEQQRK-------DKELKNQQAVEERKKRQEELDRLKQEELLKK--------Q 1140
             |..||   ::.||...|       |.|:..::.::.:..:...|:::.:|.:.||        .
Mouse    96 TASLEKLVDSAWLEIMTKYAVGEECDFEVGKEKMLKVKIVKIHPLEKVDEEAVEKKSDGACDSPS 160

  Fly  1141 QEKEKRRQEAILAKEQELQKQKEMLLAAEMERERRRQHMSLIRMLELRRKFEDREKKKHQLVLDR 1205
            .:||...|.|     |:|||::.::    .|.|.||:.::            ||.::..:.:...
Mouse   161 SDKENSSQMA-----QDLQKKETVV----KEDEGRRESIN------------DRARRSPRKLPTS 204

  Fly  1206 LLLRERRMAERKRDAEILQLIRRPNEDSEMPQELVIPELDRIAGNRLPGQAMADLLMVFEFL-HN 1269
            |...||:.|..|                                                || |.
Mouse   205 LKKGERKWAPPK------------------------------------------------FLPHK 221

  Fly  1270 FGETLGFDMESLPSLQNLHDALMSDSNADAEEELLSVMTHLLVCAIEDPGVPNPGRHTTLLGQSL 1334
                  :|::    ||| .|.::|:..||:            :...|.|  ||
Mouse   222 ------YDVK----LQN-EDKIISNVPADS------------LIRTERP--PN------------ 249

  Fly  1335 RNADITNSNVSEILRIYLYATATGEVRQMHGITVDRERERRVPDHHQLDSDTTTHSHSVKNQEYY 1399
                      .||||.::                         .|:.|.:.|
Mouse   250 ----------KEILRYFI-------------------------RHNALRAGT------------- 266

  Fly  1400 KLLHENDTWKLSQSLKDRPFVALNPTRKAQMLAHLCNDLLMNKAVLRQIDGSLETCAQMRKEK-- 1462
               .||..|.:...|..:..:   |::.:..|......:.:|.:..|:..||.:.....:.::
Mouse   267 ---GENAPWVVEDELVKKYSL---PSKFSDFLLDPYKYMTLNPSTKRRNTGSPDRKPSKKPKRDS 325

  Fly  1463 --YMTDMKVRKYKALHMRKARIEAYERAQAEREAAMQALMAQQKLDAERLKAEEEAKAAAAEEAA 1525
              ..:.:..:.:..:|:.|:                        |:...||.:....:.:.||..
Mouse   326 SSLSSPLNPKLWCHVHLEKS------------------------LNGPPLKVKNSKNSKSPEEHL 366

  Fly  1526 AAAGTDGEATKGGSPNGEK------PEDGDQNEEGAAKEPQQQQQQPMEVDGVVDEASLVSPAKT 1584
            ..      ..|..|||..|      |:.|.     |||:|.:...:|::..|         ..|.
Mouse   367 EG------VMKIMSPNNNKLHSFHIPKKGP-----AAKKPGKHSDKPLKAKG---------RGKG 411

  Fly  1585 II----QTDNSLTPSK--------------QDMPTPTYQINGSSTPTTSGVTGGDMNVLLQAKKS 1631
            |:    .|.||.:|||              .||...|.::  :.||.:||
Mouse   412 ILNGQKSTGNSKSPSKCVKTPKTKMKQMTLLDMAKGTQKM--TRTPRSSG--------------- 459

  Fly  1632 GARNSINDEHHHDVSIIDDDLSDLDSEITNVEEDEDNRLSADELQKKLDKIVRASLNCKEALEKS 1696
            |...|....|.|    :......|   |...:|::|          |.||  :::|:|  .:.|:
Mouse   460 GVPRSSGKPHKH----LPPAALHL---IAYYKENKD----------KEDK--KSALSC--VISKT 503

  Fly  1697 TNQLRAACFGQDRFWRRYWKLPKAGGIFIEALESAQNDICDYHEALEAMDDKKDANDEKENSENE 1761
            ...|.    .:||.     :||:.    :.||...:.::.::.:...:|.:::.....|:..:..
Mouse   504 ARLLS----NEDRA-----RLPEE----LRALVQKRYELLEHKKRWASMSEEQRKEYLKKKRQEL 555

  Fly  1762 KDVAAESSEQPMEVDESITKLEDGVPASDVGMPESNQQNAHQDEEDDDDDVTEINKVEPEIVDLG 1826
            |:...|.:::..| .|.:.:||              :|...:|:|....::.....|
Mouse   556 KERLREKAKERRE-REMLERLE--------------KQKRFEDQELGGRNLPAFRLV-------- 597

  Fly  1827 DDDDDAAPP--------------------LPKIEPPRPEIKVKSEMELMGPPP--------TTMI 1863
             |..:..|.                    ||..:.|   |...|.||.:....        ..:|
Mouse   598 -DTPEGLPNTLFGDVALVVEFLSCYSGLLLPDAQYP---ITAVSLMEALSADKGGFLYLNRVLVI 658

  Fly  1864 STKTDFEAEI---------KIPSMPGILMPPTLNN---------NNTNNNNNNNGSDNCDKLETG 1910
            ..:|..:.||         |:..     :|.||::         ...:...::.||:..|
Mouse   659 LLQTLLQDEIAEDYGELGMKLSE-----IPLTLHSVSELVRLCLRRCDVQEDSEGSETDD----- 713

  Fly  1911 LGLGQQQQNFSQSVIKTEDVKKEDDCIIVSTSSVDDTPKWFSIVRREVPLISELPAEEGGVVGQE 1975
               .:....|..:.::.|.::|.            :|.::|           ||.:||      :
Mouse   714 ---NKDSTPFEDNEVQDEFLEKL------------ETSEFF-----------ELTSEE------K 746

  Fly  1976 LQISYANQNCSAQL---QLQGHPWDLINNMQYYSIPMDECKVDTSKLGNECIFSLSGLDEKQMLA 2037
            |:|..|  .|...|   .:|.|              |:..:..:::|..|   .|:.|.|:....
Mouse   747 LRILTA--LCHRILMTYSVQDH--------------METRQQVSAELWKE---RLAVLKEENDKK 792

  Fly  2038 KVEEYKAHKVESKNGLGSPHRHHETKDDEEQAKLKLDK-----EIDTEMETDADDLAGKEKFFRL 2097
            :.|:.|..::|::|         :....||....|:|:     :|:.::|.:|||:....|..||
Mouse   793 RAEKQKRKEMEARN---------KENGKEENVLGKVDRKKEIVKIEQQVEVEADDMISAVKSRRL 848

  Fly  2098 RSDVPPDTGGGVSEGTDVKPKIELRLDE--------ALSQAYYHNIANMSLSSVQTYIPID---- 2150
            .| :.......:.| .:.|.::|...:|        |..:|:...||...|...:|.|..|
Mouse   849 LS-MQAKRKREIQE-RETKVRLEREAEEERMRKHKAAAEKAFQEGIAKAKLVLRRTPIGTDRNHN 911

  Fly  2151 --------IP---------------------LPLSMTPDEHRLLEQVKLAGFPERV-----HG-- 2179
                    :|                     ...|..||:. ...:.|.|...:..     ||
Mouse   912 RYWLFSNEVPGLFIEKGWVHNSIDYRFKHHRKDHSNLPDDD-YCPRSKKANLGKNASVNAHHGPA 975

  Fly  2180 -----VYVPRRQRYGWWQLDDEQKLRQLLKTLNPSGLRERELQENLQR---------FLGLEQPL 2230
                 ..||::.:..|:..|.:::|.:||..|:|.|:||.:|:|.|::         :|..:..|
Mouse   976 LEAVETTVPKQGQNLWFLCDSQKELDELLSCLHPQGIRESQLKERLEKRYQEITHSIYLARKPNL 1040

  Fly  2231 GVNYKLKSDIDFPEE---FLMPDKKGDWNPKVAKRVE---LALIEQLESLEDKVASASMQLKNWQ 2289
            |    ||| .|..:|   ||..|.     .:||.|::   |..:|.....|.:|.|.. :||
Mouse  1041 G----LKS-CDGNQELLNFLRSDL-----IEVATRLQKGGLGYMEGTSEFEARVISLE-KLK--- 1091

  Fly  2290 LPNRVESELTLDSQEDVTEEDFVSIIPMIRERIIDLEANIERRYLKPPLGSQTGDAHLAVIAQNQ 2354
                                ||       .|.:|.|:|::.:::|:.
Mouse  1092 --------------------DF-------GECVIALQASVIKKFLQG------------------ 1111

  Fly  2355 HTTTQTQNSASAAAYLLQMQQQQQQQQLAQQQQQQQQGSGAGNSLNPSSFNERTMALAAAAAASG 2419
                             .|..:|::::|..:
Mouse  1112 -----------------FMAPKQKKRKLQSE---------------------------------- 1125

  Fly  2420 PGNATGVANSAVVAGATPCESGSGEPNSGNASPASNCDSDRDEKVEQ---------IPKGLVQWR 2475
                                                 ||.:.|:|::         :...|.:|:
Mouse  1126 -------------------------------------DSTKSEEVDEEKKMVEEAKVASALEKWK 1153

  Fly  2476 DAVSRSHTTAQLAMALYVLESCVAWDKSIMKAYATKNKSSKKKSSAKKQATPSKKQQQKKNKKEQ 2540
            .|:..:.|.:::.:.|.:|::|:.||.|
Mouse  1154 TAIREAQTFSRMHVLLGMLDACIKWDMS------------------------------------- 1181

  Fly  2541 QLTPNGKESKSKSAINKPENQAPLSIKINLKALAQNGQCLLKTKTPPILTKSPTASPSSHPNTSD 2605
                                             |:|.:|
Mouse  1182 ---------------------------------AENARC-------------------------- 1187

  Fly  2606 SDSDFGKRTKKKSGGKRRRSANNTNSSKYSNSLQNCQFCTSGENEDKLLLCDGCDKGYHTYCFKP 2670
                  |..:||                             || :|||:|||.|:|.:|.:|.:|
Mouse  1188 ------KVCRKK-----------------------------GE-DDKLILCDECNKAFHLFCLRP 1216

  Fly  2671 KMDNIPDGDWYCYECVNKATNERKCIVCGGHRPSPVGKMIYCDLCPRAYHADCYIPPLLKVPRGK 2735
            .:..:|||:|.|..|
Mouse  1217 ALYEVPDGEWQCPAC-------------------------------------------------- 1231

  Fly  2736 WYCHGCISRAPPPKKRSAGGTSGSSSKSRRDRDRESGGSAKRRSDNSKTPAMEHMQQQQMPLAGG 2800
                     .||..:|::.|.:.:...:....:.:..|..:...:.      |..:::...:||
Mouse  1232 ---------QPPTARRNSRGRNYTEESTSEGSEGDESGEEEEEEEE------EEEEEEDYEVAG- 1280

  Fly  2801 DSHHHHHQQPPSLNSSHDESMNSLPAAPLSPAHSVVSATNYDDQHHANNSVDGSSRFHAHLIPPS 2865
                                :...|...:....||:
Mouse  1281 --------------------LRLRPRKTIRGKQSVI----------------------------- 1296

  Fly  2866 NNGTAALLEDVPGGANVMPGVYPVYTPVAAGNFSAGLINQAPVQPAMPFANVVAMSPRAVTPTRT 2930
                                                                             
Mouse  1297 ----------------------------------------------------------------- 1296

  Fly  2931 RTPTPTPAPTPPPPPPTPLLMQASPTATALHVNACQSPPQQQHAQLMTMPSPPAIGVGTATNQMS 2995
                  ||..|..|                       |.::.|....:.|.             .
Mouse  1297 ------PAARPGRP-----------------------PGKKSHPARRSRPK-------------D 1319

  Fly  2996 PPPINIHAIQEAKEKLKQEKKEKHATKKLMKELAVCKTLLGEMELHEDSWPFLLPVNTKQFPTYR 3060
            .|.::...:|           .|..:::...||..|:.:|.::..:..||||..||...:...|.
Mouse  1320 DPEVDDLVLQ-----------TKRISRRQSLELQKCEDILHKLVKYRFSWPFREPVTRDEAEDYY 1373

  Fly  3061 KIIKTPMDLSTIKKKLQDLSYKTREDFCVDVRQIFDNCEMFN 3102
            .:|:.|||..||:.|....:|::.::|..|::|:|.|.|::|
Mouse  1374 DVIEHPMDFQTIQNKCSCGNYRSVQEFLTDMKQVFANAELYN 1415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tou	NP_001097270.1	HAT_MBD	953..1027	CDD:238691
		TPH	<1041..1228	CDD:464007	46/216 (21%)
		PTZ00121	<1045..1681	CDD:173412	121/696 (17%)
		DDT	1255..1317	CDD:460696	11/62 (18%)
		WSD	1700..>1726	CDD:464775	5/25 (20%)
		WSD	<2173..2222	CDD:464775	17/60 (28%)
		PHD_BAZ2A_like	2640..2685	CDD:277020	18/44 (41%)
		RanBP2-type Zn finger	2680..2698	CDD:275376	3/17 (18%)
		PHD	2695..2741	CDD:214584	0/45 (0%)
		Bromo_BAZ2A_B_like	3027..3123	CDD:99935	26/76 (34%)
Baz1b	NP_035844.2	WAC_Acf1_DNA_bd	21..120	CDD:463140	21/88 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	146..212		20/86 (23%)
		C motif	207..213		2/5 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	302..333		4/30 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	376..433		18/70 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	448..472		9/44 (20%)
		DDT	605..669	CDD:214726	10/66 (15%)
		WHIM1	728..768	CDD:464774	15/84 (18%)
		DUF5401	<764..>862	CDD:375164	26/125 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	789..813		4/32 (13%)
		WSD	899..1025	CDD:464775	26/126 (21%)
		PHD_BAZ1B	1186..1231	CDD:277098	22/106 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1231..1324		20/314 (6%)
		Bromo_WSTF_like	1340..1436	CDD:99937	26/76 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1451..1479