DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tou and Chd3

DIOPT Version :9

Sequence 1:	NP_001097270.1	Gene:	tou / 36241	FlyBaseID:	FBgn0033636	Length:	3131	Species:	Drosophila melanogaster
Sequence 2:	XP_017169944.1	Gene:	Chd3 / 216848	MGIID:	1344395	Length:	2111	Species:	Mus musculus

Alignment Length:	782	Identity:	157/782 - (20%)
Similarity:	249/782 - (31%)	Gaps:	311/782 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly  2031 DEKQMLAKVEEYKAHKVESKNGLGSPHRHHETKDDEEQAKLKLDKEIDTEMETDADDLAGKEKFF 2095
            :|::|:...||                ...|.:.|||:.:::...|.|.  |.|.:.:.|:
Mouse    11 EEEEMVVSEEE----------------EEEEEEGDEEEEEVEAADEDDE--EEDEEGVLGR---- 53

  Fly  2096 RLRSDVPPDTGGGVSEGTDVKPKIELRLDEALSQAYYHNIANMSLSSVQTYIPIDIPLPLSMTPD 2160
                      |.|.....|                      ..|..|...:.|...|||....||
Mouse    54 ----------GPGHDRSRD----------------------RHSPPSCHLFPPPPPPLPPPPPPD 86

  Fly  2161 EH--RLLEQVKLAGFPERVHGVYVPRRQRYGWWQLDDEQKLRQLLKTLNPSGLRERELQENLQRF 2223
            :.  |||...  .|..:|..|   |::|:        |.|         |...|:|:..::.:.|
Mouse    87 KDDIRLLPSA--LGVKKRKRG---PKKQK--------ENK---------PGKPRKRKKLDSEEEF 129

  Fly  2224 LGLEQPLGVNYKLKSDIDFPEEFLMPDKKGDWNPKVAKRVELALIEQLE------SLEDKVASAS 2282
             |.|:.   .|:.||:....|....|.:|.....:..|..:....::.|      .:|.|  |::
Mouse   130 -GSERD---EYREKSESGGSEYGTGPGRKRRRKHREKKEKKTKRRKRGEGDGGHKQVEQK--SSA 188

  Fly  2283 MQLKNWQLPNRVESELTLDSQEDV----TEEDFVSIIPMIRERIIDLEANIERRYLKPPLGSQTG 2343
            ..|..|.|             |||    :|||:
Mouse   189 TLLLTWGL-------------EDVEHVFSEEDY-------------------------------- 208

  Fly  2344 DAHLAVIAQNQHTTTQTQNSASAAAYLLQMQQQQQQQQLAQQQQQQQQGSG----AGNSLNPSSF 2404
                       ||.|    :..|.:..::....::..::...:.....|:.    :.|  ||  |
Mouse   209 -----------HTLT----NYKAFSQFMRPLIAKKNPKIPMSKMMTILGAKWREFSAN--NP--F 254

  Fly  2405 NERTMALAAAAAASGPGNATGVANSAVVAGATPCESGSGEPNSGNASPASNCDSDRDEKVEQIPK 2469
            .....|:||||||:....|..|  ||.|:.|||. :.||.|.:....||        .:::..|
Mouse   255 KGSAAAVAAAAAAAAAAVAEQV--SAAVSSATPI-APSGPPPALPPPPA--------PEIQPPP- 307

  Fly  2470 GLVQWRDAVSRSHTTAQLAMALYVLESCVAWDKSIMKAYATKNKSSKKKSSAKKQATPSKKQQQK 2534
                    :.|:.|                                      |:...|..|::.|
Mouse   308 --------IRRAKT--------------------------------------KEGKGPGHKRRNK 326

  Fly  2535 KNKKEQQLTPNGKESKSKSAINKPENQAPLSIKINL------KALAQNGQCLLKTKTPPILTKSP 2593
            ..:     .|:|::..      :.:..|||.||:.|      ||    |.|..:
Mouse   327 SPR-----VPDGRKKL------RGKKMAPLKIKLGLLGGKRKKA----GSCAFQ----------- 365

  Fly  2594 TASPSSH-PNTSDSDSDFG---------------KRTKKKSGGKRRRS-------ANNTNSSKYS 2635
              |...| |...:||.|.|               |:.|:...|::::.       ........|.
Mouse   366 --SEEGHEPEAEESDLDSGSVHSASGWPDGPVRAKKLKRGRPGRKKKKVLGCPAVTGEEEVDGYE 428

  Fly  2636 NSLQN-CQFCTSGENEDKLLLCDGCDKGYHTYCFKPKMDNIPDGDWYCYECVN-----KATNERK 2694
            ...|: |:.|..|   .:::|||.|.:.||..|..|::|..|:|.|.|..|..     :|..|.:
Mouse   429 TDHQDYCEVCQQG---GEIILCDTCPRAYHLVCLDPELDRAPEGKWSCPHCEKEGVQWEAKEEEE 490

  Fly  2695 --------------------CIVCGGHRPSPVGKMIYCDLCPRAYHADCYIPPLLKVPRGKWYCH 2739
                                |.||     ...|:::.||.|..:||..|..|||..:|.|:|.|.
Mouse   491 EYEEEGEEGEKEEEDDHMEYCRVC-----KDGGELLCCDACISSYHIHCLNPPLPDIPNGEWLCP 550

  Fly  2740 GC 2741
            .|
Mouse   551 RC 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tou	NP_001097270.1	HAT_MBD	953..1027	CDD:238691
		ZapA	1021..1127	CDD:294720
		MAP7	1043..1198	CDD:283355
		RILP-like	1085..>1179	CDD:304877
		DDT	1255..1317	CDD:280886
		WHIM1	1406..1455	CDD:292246
		WHIM3	2190..2224	CDD:292248	5/33 (15%)
		PHD_BAZ2A_like	2640..2685	CDD:277020	16/45 (36%)
		RanBP2-type Zn finger	2640..2659	CDD:275375	6/19 (32%)
		RanBP2-type Zn finger	2680..2698	CDD:275376	6/42 (14%)
		PHD	2695..2744	CDD:279022	18/47 (38%)
		Bromo_BAZ2A_B_like	3027..3123	CDD:99935
Chd3	XP_017169944.1	CHDNT	200..253	CDD:369683	9/101 (9%)
		PHD1_CHD_II	434..476	CDD:277006	16/44 (36%)
		PHD2_CHD_II	510..552	CDD:277007	17/46 (37%)
		CD1_tandem_CHD3-4_like	557..635	CDD:349314
		CD2_tandem_CHD3-4_like	680..734	CDD:349309
		PLN03142	771..>1325	CDD:215601
		DEXHc_CHD3	788..1019	CDD:350813
		DUF1087	<1364..1407	CDD:368924
		DUF1086	1430..1569	CDD:368921
		PHA03169	1589..>1759	CDD:223003
		CHDCT2	1790..>1917	CDD:369684
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0383
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900