DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tou and Phf21a

DIOPT Version :9

Sequence 1:	NP_001097270.1	Gene:	tou / 36241	FlyBaseID:	FBgn0033636	Length:	3131	Species:	Drosophila melanogaster
Sequence 2:	XP_011237664.1	Gene:	Phf21a / 192285	MGIID:	2384756	Length:	695	Species:	Mus musculus

Alignment Length:	890	Identity:	180/890 - (20%)
Similarity:	277/890 - (31%)	Gaps:	375/890 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly  2215 ELQENLQRFLGLEQPLGVNYKL----KSDIDFPEEFLMPDKKGDWNPKVAKRVELALIEQLESLE 2275
            ||| .||..|.:|  :.|:.||    |.|   |:.|.:.::..|            |.:||..|:
Mouse     2 ELQ-TLQEALKVE--IQVHQKLVAQMKQD---PQIFFLSNQNAD------------LKKQLHELQ 48

  Fly  2276 DKVASASMQLKNWQLPNRVESELTLDSQEDVTEEDFVSIIPMIRERIIDLEANIERRYLKPPLGS 2340
            .|:.:.|                  :.|:.|.|:        :|:.:|..:...::..::|.  |
Mouse    49 AKITALS------------------EKQKRVVEQ--------LRKNLIVKQEQPDKFQIQPL--S 85

  Fly  2341 QTGDAHLAVIAQNQHTTTQTQNSASAAAYLLQMQQQQQQQQLAQQQQQQQQGSGAGNSLNPS-SF 2404
            |         ::|:..|.|.|.        ||..||||.||..||||||||.:....:..|| :.
Mouse    86 Q---------SENKLQTAQQQP--------LQPLQQQQPQQPQQQQQQQQQHAQQSAAAPPSLTA 133

  Fly  2405 NERTMALAA------------AAAASGPGNATGVANSAVVAGATPCESGSGEPNSGNASPASNCD 2457
            :::|:..|:            ||.|:.|.:..|...:..:..|.         ||..|..:::
Mouse   134 SQKTVTTASMITTKTLPLVLKAATATMPASVVGQRPTIAMVTAI---------NSQKAVLSTD-- 187

  Fly  2458 SDRDEKVEQIPKGLVQWRDAVSRSHTTAQLAMALYVLESCVAWDKSIMKAYATKNKSSKKKSSAK 2522
                  |:..|..|      .:.|..|...|.|:.::                    :|...:.:
Mouse   188 ------VQNTPVNL------QTSSKVTGPGAEAVQIV--------------------AKNTVTLQ 220

  Fly  2523 KQATPSKKQQQKKNKKEQQLTPNGK-----ESKSKSAINKPENQAP--------------LSIKI 2568
            .||||.:..:..:.....:|||...     ..|..:..|.|...||              :..|.
Mouse   221 VQATPPQPIKVPQFIPPPRLTPRPNFLPQVRPKPVAQNNIPIAPAPPPMLAAPQLIQRPVMLTKF 285

  Fly  2569 NLKAL-----------AQNGQCLLKTKTPPI--LTKSPTASP----------------------S 2598
            ....|           ..|||.....||.|:  ||....|:|                      .
Mouse   286 TPTTLPTSQNSIHPVRVVNGQTATIAKTFPMAQLTSIVIATPGTRLPGPQTVQLSKPSLEKQTVK 350

  Fly  2599 SHPNTSDSDSDFGKRT------------------------------------KKKSGGKRRRSAN 2627
            |||...:..::  .||                                    .|:...|||.:||
Mouse   351 SHPEAEEKQAE--SRTVTPPAAPKPKREENPQKLAFMVSLGLVTHDHLEEIQSKRQERKRRTTAN 413

  Fly  2628 NTNSS------------KYSNSLQN---------------------------CQFCTSGENEDKL 2653
            ...|.            .|.||..:                           .....|.|||
Mouse   414 PVYSGAVFEPERKKSAVTYLNSTMHPGTRKRGRPPKYNAVLGFGALTPTSPPSSHPDSPENE--- 475

  Fly  2654 LLCDGCDKGYHTYCFKPKMD--NIP-----DGDWYCYECVNKATNERKCIVCGGHRPSPVGKMIY 2711
                   |...|:.|...:.  ::|     |||          .:|..|.||   |.|  |:::.
Mouse   476 -------KTETTFTFPAPVQPVSLPSPTSTDGD----------IHEDFCSVC---RKS--GQLLM 518

  Fly  2712 CDLCPRAYHADCYIPPLLKVPRGKWYCHGCISRAPPPKKRSA---GGT-----SGSSSKSRRDRD 2768
            ||.|.|.||.||..|||..:|:|.|.|..|..:.  .||..|   .||     |..:.|:.::.:
Mouse   519 CDTCSRVYHLDCLEPPLKTIPKGMWICPRCQDQM--LKKEEAIPWPGTLAIVHSYIAYKAAKEEE 581

  Fly  2769 RESGGSAKRRSDNSKTPAMEHMQQQQMPLAGGDSHHHHHQQPPSLNSSHDESMNSLPAAPLSPAH 2833
            ::.  ..|..||         ::|::..|         .|:...|:||..:.|..        ..
Mouse   582 KQK--LLKWSSD---------LKQEREQL---------EQKVKELSSSISKCMEM--------KS 618

  Fly  2834 SVVSATNYDDQHHANNSVDGSSRFHAHLIPPSNNGTAALLEDVPGGANVMPGV---YPVYTPVAA 2895
            |:::.     |....:|:|...|.                      ..::.||   .||.:...|
Mouse   619 SILAR-----QKEMRSSLDKVKRL----------------------IRLVHGVDLCRPVDSEATA 656

  Fly  2896 GNFSAGLINQAPVQPAMPFANVVAMSPRAVTPTRTRTPTPTPAPT 2940
            |..|.|                    |.. ||......||.|:|:
Mouse   657 GALSNG--------------------PDC-TPPANAASTPAPSPS 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tou	NP_001097270.1	HAT_MBD	953..1027	CDD:238691
		ZapA	1021..1127	CDD:294720
		MAP7	1043..1198	CDD:283355
		RILP-like	1085..>1179	CDD:304877
		DDT	1255..1317	CDD:280886
		WHIM1	1406..1455	CDD:292246
		WHIM3	2190..2224	CDD:292248	5/8 (63%)
		PHD_BAZ2A_like	2640..2685	CDD:277020	11/78 (14%)
		RanBP2-type Zn finger	2640..2659	CDD:275375	4/45 (9%)
		RanBP2-type Zn finger	2680..2698	CDD:275376	2/17 (12%)
		PHD	2695..2744	CDD:279022	22/48 (46%)
		Bromo_BAZ2A_B_like	3027..3123	CDD:99935
Phf21a	XP_011237664.1	PHD_PHF21A	506..548	CDD:276998	21/46 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0383
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900