Protein Alignment tou and bet-2

DIOPT Version :9

• Sequence 1: NP_001097270.1
• Gene: tou / 36241
• FlyBaseID: FBgn0033636
• Length: 3131
• Species: Drosophila melanogaster
• Sequence 2: NP_001300353.1
• Gene: bet-2 / 181257
• WormBaseID: WBGene00010199
• Length: 1209
• Species: Caenorhabditis elegans
• Alignment Length: 1489
• Identity: 275/1489 - (18%)
• Similarity: 462/1489 - (31%)
• Gaps: 564/1489 - (37%)

  Fly  1546 EDGDQNEEGAAKEPQQQQQQPMEVDGVVDEASLVSPAKTI----IQTDN----SLTPSKQDMPTP 1602
            :|.|||:|                    ||..:.|  |||    :|.::    ..:|::.|..:.
 Worm    23 DDSDQNDE--------------------DETLIAS--KTIQTGAVQVNDIAVAEASPAETDAKSS 65

  Fly  1603 TYQINGSSTPTTSGVTGGDMNVLLQAKKSGARNSINDEHHHDVSIIDDDL--------SDLDSEI 1659
            ...::|...||::.|...|::..  .|:||:.:...:|.:.|....::.:        :|:..:.
 Worm    66 ASPVSGPEPPTSAVVENRDLDEF--KKESGSNDDKQEEINEDKDSNEETVFQQTESGSADVVDKT 128

  Fly  1660 TNVEEDEDNRLSADELQKKLDKIVRASLNCKEALEKSTN----QLRAACFGQDRFWRRYWKLPKA 1720
            ...::|.|:....|....|     ..|::..:..:.||.    |..|:..|.::..:
 Worm   129 DVKQKDSDSSADDDHSHSK-----SGSVHSPQKPQGSTTPCSVQSPASPVGDEQAVK-------- 180

  Fly  1721 GGIFIEALESAQNDICDYHEALEAMDDKKDANDEKENSENEKDVAAESSEQPMEVDESITKLEDG 1785
                   :|..:..|.    |.|.:.||| ....||::::|    :..||...|..::..|:||
 Worm   181 -------MEEVEEPIV----ASEEVPDKK-PESVKESTDSE----SSGSEHGFEKMDTAEKVED- 228

  Fly  1786 VPASDVGMPESNQQNAHQDEEDDDDDVTEINKV-EPEIVDLGDDDDDAAPP--LPKIEPPRPEIK 1847
                                |.:||:|...|.. |||   .||...|...|  .|:.||....::
 Worm   229 --------------------ECNDDEVAASNGTEEPE---PGDKAADTVNPWETPRQEPVDGVVQ 270

  Fly  1848 VKSEMELMGPPPT---TMISTKTDF-----------------------EAEIKIPSMPGILMPP- 1885
            .::|      ||.   |..:...||                       ..:::||....|:..|
 Worm   271 PRTE------PPAGKPTRHTNCLDFVLFTVVKDALKHKHSWPFQLPVDAIKLEIPEYHNIVNTPM 329

  Fly  1886 ---TLNNNNTN---------NNNNNNGSDNCDKLETGLGLGQQQQNFSQSVIKTEDVKKEDDCII 1938
               |:.....|         ..:.|...|||.|..                      .:.|| |.
 Worm   330 DLRTIEKRLRNLYYWCAEDAIKDLNTLFDNCKKFN----------------------DRNDD-IY 371

  Fly  1939 VSTSSVDDTPKWFSIVRREVPLISELPAEEGGVVGQELQISYANQNCSAQLQLQGHPWDLINNMQ 2003
            :...:::                        |||.:.|:                  |
 Worm   372 IMCENIE------------------------GVVQRGLE------------------W------- 387

  Fly  2004 YYSIPMDECKVDTSKLGNECIFSLSGLDEKQMLAKVEEYKAHKVESKNGL--GSPHRHHETKD-- 2064
               :|.:|...|.:......:||.|....|....|....|:.:...|..|  |:.....|:.|
 Worm   388 ---MPSEEKPADLADHHRRGMFSASTPSGKTKGPKQRGRKSTRGRKKTSLPRGASTFKDESVDDN 449

  Fly  2065 -DEEQAK---LKLDKEIDTEMETDADDLAGKEKFFRLRSDVPPDTGGGVSEGTDVKPKIELRLDE 2125
             |:|.:|   :..|.:.||..|.||:..|         ..|.|:......:.:..:|..:.|..|
 Worm   450 NDDESSKVDSINFDDDDDTATEKDAESRA---------ESVQPEVVNEEPKPSTSQPPSKKRKAE 505

  Fly  2126 ALSQAYYHNIANMSLSSVQTYIPIDIPLPLSMTPDE--------HRLLEQVKLAGFPERVHGVYV 2182
            ....|....||..:             .|::..|.|        :.|:|...|           |
 Worm   506 NGEPAVAVKIATPA-------------TPVAAHPQEETPRRKNPNTLIEWKHL-----------V 546

  Fly  2183 PRRQ-RYGWWQLDDEQKLRQLLKTLN------------PSGLRERELQENLQRFLGLEQPLGVNY 2234
            ||.| :...||....:.|.::....|            |..|:..:..|.:...:.|:
 Worm   547 PRWQGKIPEWQKFCSKLLNEIHSVKNKGFAQVFYLPVDPIKLKIYDYLEVITNPMDLQ------- 604

  Fly  2235 KLKSDIDF-----PEEF-----LMPDKKGDWNPKVAKRVELALIEQLESLEDKVASASMQLKNWQ 2289
            .:|..:||     ||||     ||.|....:|||.:.....||  :|.|..:         :.|:
 Worm   605 TIKKKLDFKQYAEPEEFVHDINLMVDNCCKYNPKGSPAHSNAL--ELRSFFE---------QRWK 658

  Fly  2290 L-PNRVESELTLDS---QEDVTEEDFVSIIPMIRERIIDLEANIERRYLKPPLGSQTGDAHLAVI 2350
            | |......:..||   |..|...|.:.     .|||        ..||.            ||.
 Worm   659 LFPRPGVDPIIADSYINQNLVVNTDLIE-----DERI--------NSYLS------------AVK 698

  Fly  2351 AQNQHTTTQTQ--NSASAAAYLLQMQQQQQQ------QQLAQQQQQQQQGSGAG----------- 2396
            |:.:....:.:  .|.|...|.:.||:::.:      ..|||.|..|.:|.|..
 Worm   699 AEEKKCAEKLEQLRSMSEGLYTIAMQRREAKLAGNTAPALAQNQLSQLEGLGISIKSTPMMIPEL 763

  Fly  2397 -------------------NSLNPSSFNERTMALAAAAAASG---PGNATGVANSAVVAGATPCE 2439
                               :.:.||....|.::...|:.||.   |...||...     |..|
 Worm   764 ISPALSVRSSSRAPVPKIIDDIGPSPIKARKISKPRASMASNVSVPYTPTGNPR-----GRKP-- 821

  Fly  2440 SGSGEPNSGNASPASNCDSDRDEKVEQIP------------KGLVQWRDAVSRSHTTAQLAMALY 2492
            ..||.|.....|||:     ..|::.|.|            :.:|...|.:..|...|.:.. :|
 Worm   822 KKSGRPKKNIYSPAT-----VSERISQQPPFEVTPYVSIYGRKVVGTNDKIELSERMASIPQ-MY 880

  Fly  2493 VLESCVAWDKSIMKAYATKNKSSKKKSSAKKQATPS----------------------KKQQQKK 2535
            :        ..|::.....:.::.|..::.:.....                      :|.:.|.
 Worm   881 I--------TPILRIIQIGHHNTGKTITSLRSLCEEEIDFNDVSDDLVIELLDYLEMIQKDKAKA 937

  Fly  2536 NKKEQQLTPNGKESKSK-----------SAINKPENQAPLSIKINLKALAQNGQCLLKTKTPPIL 2589
            .:..|:|     |.|:|           ..|.|..|..|..            |..:::.:|
 Worm   938 EQVRQEL-----EVKAKFYGFEAYDNKLGTIPKTRNMPPPL------------QHRMRSDSP--- 982

  Fly  2590 TKSPTASPSSHPNTSDSDS-------DFGKRTKKKSGGKRRRSANNTNSSKYSNSLQNCQFCTSG 2647
              ||:||.:.: .:|||||       |...|:.....|.||....:.|||..|.        .:|
 Worm   983 --SPSASRTGN-QSSDSDSASDDSSDDEPSRSNSNVAGPRRALELSGNSSSAST--------PAG 1036

  Fly  2648 ENEDKLLLCDGCDKGYHTYCFKPKMDNIPDGDWYCYECVNKATNERKCIVCGG---------HRP 2703
            .::.:..:            .:|...::.....|....::::::...   ..|         ..|
 Worm  1037 PSKAQPAV------------VRPSSKSVASKPAYTKRTLSESSSSSD---SNGSSSDSSDSDSEP 1086

  Fly  2704 SPVGKMIYCDLCPRAYHADCYIPPLLKV-----PRGKWYCHGCISRAP-----------PPKK-- 2750
            .|..|.      |.        ||..||     |:.|       .:||           |.||
 Worm  1087 KPQAKK------PE--------PPQKKVAKKPAPQQK-------KKAPLSILDELLPDTPEKKPV 1130

  Fly  2751 -RSAGGTSGSS----------------SKSRRDRDRESGGSAKRRSDNSKTPAMEHMQQ 2792
             .|...||||:                ::.:..:::|...:.:||.:..:..|:|..||
 Worm  1131 MASVPTTSGSARQLPPDSYQKPSQISEAELKAQKEQEHNAALQRREEARRLRALEDQQQ 1189

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tou	NP_001097270.1	HAT_MBD	953..1027	CDD:238691
		ZapA	1021..1127	CDD:294720
		MAP7	1043..1198	CDD:283355
		RILP-like	1085..>1179	CDD:304877
		DDT	1255..1317	CDD:280886
		WHIM1	1406..1455	CDD:292246
		WHIM3	2190..2224	CDD:292248	7/45 (16%)
		PHD_BAZ2A_like	2640..2685	CDD:277020	3/44 (7%)
		RanBP2-type Zn finger	2640..2659	CDD:275375	1/18 (6%)
		RanBP2-type Zn finger	2680..2698	CDD:275376	1/17 (6%)
		PHD	2695..2744	CDD:279022	11/62 (18%)
		Bromo_BAZ2A_B_like	3027..3123	CDD:99935
bet-2	NP_001300353.1	Bromodomain	282..388	CDD:295360	21/180 (12%)
		COG5076	429..>661	CDD:227408	60/282 (21%)
		Bromo_Brdt_II_like	556..657	CDD:99930	25/118 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165218
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.930