Protein Alignment tou and athp-2

DIOPT Version :10

• Sequence 1: NP_001097270.1
• Gene: tou / 36241
• FlyBaseID: FBgn0033636
• Length: 3131
• Species: Drosophila melanogaster
• Sequence 2: NP_494767.2
• Gene: athp-2 / 173769
• WormBaseID: WBGene00019217
• Length: 1412
• Species: Caenorhabditis elegans
• Alignment Length: 2053
• Identity: 333/2053 - (16%)
• Similarity: 551/2053 - (26%)
• Gaps: 953/2053 - (46%)

  Fly  1376 VPDHHQLDSDT----TTHSHSVKNQEYYK--LLHENDTWKLSQSLKDR--PFVALNPTRKAQMLA 1432
            |||....|:..    .|....:.::||:.  :|..:..|..|.:.|..  .|.|:...|:|:.
 Worm    14 VPDGVTRDTPVFYCKATKEVFLTHEEYFNRMILLNSTAWSCSLTRKSNLTYFEAIASEREAEQ-- 76

  Fly  1433 HLCN---------DLLMNKAVLR-QIDGSLETCAQMRKEKYMTDMKV------RKYKALHMRKAR 1481
            .|||         .|:::|...| :.:..:.....:.|:::..:.:|      ||:.|..:...:
 Worm    77 ELCNFPTALEIPITLIVHKYTNRGRFEDLVNDIYHILKDRFFNNEEVAYAEKSRKFLAKIVESNQ 141

  Fly  1482 IE----------------------------AYERAQAEREAAMQALM-----------AQQKL-- 1505
            ||                            ..:.|.:|.|...:.:.           ::||:
 Worm   142 IEEQNPSFEGGSELKEPILPPPDTFRYTLQILDPAVSEEEMYREGIAFDRLFRSKNIGSRQKIRL 206

  Fly  1506 ----------DAER--LKAEEEAKAAAAEEAAAAAGTD------GEATKGGSPNGEKPEDGDQNE 1552
                      |:||  ||.:...|..........:|.:      ....:|.:||..|..|.::.|
 Worm   207 FLKNCCQMSPDSERYTLKFQFLEKIDNLYWTDVMSGAEPICPQTPALQRGRAPNTLKAGDHERKE 271

  Fly  1553 EGAAKEPQQQQQQPMEVDGVVDEASLVSPAKTIIQTDNSLTPSKQDMPTPTYQIN-----GSSTP 1612
                |:|:::::.|     .........|.|         ||.::.:.....|:.     |...|
 Worm   272 ----KKPKKEERDP-----AAPPRPRGRPPK---------TPEQKALDKKEKQMRKRAEAGREAP 318

  Fly  1613 -------TTSGVTGGDMNVLLQAKKSGARNSINDEHHHDVSIIDDDLSDLDSEITNVEEDEDNRL 1670
                   |:||.      :.|....|.|:..|..|....:|
 Worm   319 KPDDFDLTSSGA------MTLSIPVSPAKKKIRRESGSSMS------------------------ 353

  Fly  1671 SADELQKKLDKIVRASLNCKEALEKSTNQLRAACFGQDRFWRRYWKLPKAGGIFIEALESAQ--- 1732
                 .||..||:              .|....||    |:....:|    ||.:..||..:
 Worm   354 -----GKKKTKIL--------------EQQGELCF----FFSEARRL----GIDVGGLEQEEKLL 391

  Fly  1733 --NDICDYHEALEAMDDKKDANDEKENSENEKDVAAESSEQPMEVDESITKLEDGVPASDVGMPE 1795
              ..:.|:.:.::   ::|||  |||.::.||                              ..:
 Worm   392 SGKAVADFKQRVK---EEKDA--EKERAKEEK------------------------------KRK 421

  Fly  1796 SNQQNAHQDEEDDDDDVTEINKVEPEIVDLGDDDDDAAPPLPKIEPPR----------------- 1843
            ..::.|:..:.:|    ...|.::|            .|..||:|.|.
 Worm   422 MREKTAYNKKRED----LICNDLKP------------LPRFPKLEIPEWISNAEFEDYLFIFQFF 470

  Fly  1844 ---------PEIKVKSEMEL--------MGPPPTT--------MISTKTDFEAEIKIPSMPGILM 1883
                     .||:...|::.        ...|..:        ::|.:||...|
 Worm   471 NSFKQLLPLKEIRGSDEVQFSDIIIAIKCNDPQNSSFADLLRVLLSIRTDIADE----------- 524

  Fly  1884 PPTLNNNNTNNNNNNN----GSDNCDKLETGLGLGQQQQNFSQSVIKTED----VKKEDDCIIVS 1940
               .:.:..:.||...    .:.|||......|         .|:....|    ::|      :.
 Worm   525 ---EDGDEADINNREEVYLINAQNCDPAHVTHG---------DSIRDLSDLHFKIRK------IH 571

  Fly  1941 TSSVDDTPKWFSIVRREVPLISELPAEEGGVVGQELQISYANQNCSAQLQLQGHPWDLINNMQYY 2005
            ..||...|..:..:...:.||.|......|:.....:: ||.                 .|.:.|
 Worm   572 GKSVRHLPVDWMTLTEVLRLIFETSGYYTGMATHRHRL-YAR-----------------GNFRGY 618

  Fly  2006 SIPMDECKVD----TSKLGNECIFSLSGLDEKQM-------LAKVEEYKAHKVESKNGLGSPHRH 2059
            ..|..|.:..    ..||....:|.|...:..::       |....:::.|..:.:|.|....|
 Worm   619 EDPAYEFRTRHPGIMEKLRTLTVFDLEAPERLEIVKTLIYQLLTYSKFRGHLEQRQNELVELKR- 682

  Fly  2060 HETKDDEEQAKLKLDKEIDTEMETDADDLAGKEKFFRLRSDVPPDTGGGVSEGTDVK-------- 2116
                   ||.|||. .::..|.|.:|         .||..::.|   .|.|...|||
 Worm   683 -------EQKKLKA-WDVGQEGEANA---------ARLLLELAP---AGASGAPDVKEQKEPPVV 727

  Fly  2117 -----------------------------PKIELRLDE------------------ALSQAY--Y 2132
                                         |...|.|||                  .:|:.:  |
 Worm   728 RRLKAHIKAINEGRRYDKEDLDAIVLESVPYASLSLDEIVTARELQKSEFKILMDSLISKMFQIY 792

  Fly  2133 HNIANMSLSSVQTY-----------------------IPIDIPL----PLSMTPDEHRLLEQVKL 2170
            ..|:::.|.|.:.|                       |..|.|.    ||::..:||:  |....
 Worm   793 SKISDIRLGSDRAYRRYIVMENLSAILVETATFQELGIYCDEPSIIDDPLNLLENEHQ--EVFIC 855

  Fly  2171 AGFPE--RVHGVYVPRRQRYGWWQLDDEQKLRQLLKTLNPSGLRERELQENLQRFLG-----LEQ 2228
            .|..:  ||||.......|  |..:.|.::..||||:|||.|.||.||.|.|..:..     ||:
 Worm   856 TGNMDTCRVHGDESNNWTR--WSYIRDREQFEQLLKSLNPRGNREVELLEELNEYRPSLLEILEE 918

  Fly  2229 PLGVNYKLKSDIDFPEEFLMPDKKG------DWNPKVAKRVELALIEQLESLEDKVASASM-QLK 2286
            ...::.:.:.:.::..:|:..|...      ||:.::.        :.|...|:|:....| .::
 Worm   919 TERLHEEEEDEDEWKSQFMTNDPNPGDTYNIDWDAEMR--------DLLLDFEEKIDQGQMGSIE 975

  Fly  2287 NWQLPNRVESELTLDSQEDV---TEEDFVSIIPMIRERIIDLE----------------ANIERR 2332
            .....||:|....|....:|   ..|| :||...|...:.:.|                .:|..:
 Worm   976 KIFECNRIEWRDNLKESGNVCMLLNED-ISIFGEISVNLEESEHFSDSMKLAIAFYMIIKSIHLK 1039

  Fly  2333 YLKPPLGSQTGDAHLAVIAQNQHTTTQTQNSASAAAYLLQMQQQQQQQQLAQQQQQQQQGSGAGN 2397
            ::|.|..|...|.|                                                 ||
 Worm  1040 FIKAPYISPNKDEH-------------------------------------------------GN 1055

  Fly  2398 SLNPSSFNERTMALAAAAAASGPGNATGVANSAVVAGATPCESGSGEPNSGNASPASNCDSDRDE 2462
             |.||..
 Worm  1056 -LKPSEL---------------------------------------------------------- 1061

  Fly  2463 KVEQIPKGLVQWRDAVSRSHTTAQLAMALYVLESCVAWDKSIMKAYATKNKSSKKKSSAKKQATP 2527
                    .::|:.|:....:.:.|::.:...|..:.||||.::.   |.:|.::|::|
 Worm  1062 --------FIRWQRALLECESHSALSLFISTFEGSIKWDKSRLQG---KCRSCRRKAAA------ 1109

  Fly  2528 SKKQQQKKNKKEQQLTPNGKESKSKSAINKPENQAPLSIKINLKALAQNGQCLLKTKTPPILTKS 2592
                                                                             
 Worm  1110 ----------------------------------------------------------------- 1109

  Fly  2593 PTASPSSHPNTSDSDSDFGKRTKKKSGGKRRRSANNTNSSKYSNSLQNCQFCTSGENEDKLLLCD 2657
                                                                      ..|:||.
 Worm  1110 ----------------------------------------------------------HDLVLCS 1116

  Fly  2658 GCDKGYHTYCFKPKMDNIPDGDWYCYEC---VNKATNERKCIV--------CGGHRPSPVGKMI- 2710
            .||..||..|.|..:::....||.|..|   ..|..||.|.:.        ........:|.:.
 Worm  1117 ECDNCYHLKCAKLDVNSDAPADWMCTSCRAQQRKVENEAKRMARDDDQLAESSSQEDVAIGNISI 1181

  Fly  2711 ---YCDLCPRAYH--ADCYIPPLLKVPRGKWYCHGCISRAPPPKKRSAGGTSGSSSKSRRDRDRE 2770
               :.::.|:...  ..|..|...|               .||..|:|   ||.:.|.....|..
 Worm  1182 SDNFSEIAPKTAEPAESCSTPTTSK---------------EPPTIRTA---SGRAVKRVHYSDIH 1228

  Fly  2771 SGGSAKRRSDNSKTPAMEHMQQQQMPLAGGDSHHHHHQQPPSLNSSHDESMNSLPAAPLSPAHSV 2835
            .|.|.|.|..|                                        .|:|..|.......
 Worm  1229 EGLSLKNRKSN----------------------------------------GSMPVTPSERPVRN 1253

  Fly  2836 VSATNYDDQHHANNSVDGSSRFHAHLIPPSNNGTAALLEDVPGGANVMPGVYPVYTPVAAGNFSA 2900
            ||...:|.::. |...|                     ||...|.|
 Worm  1254 VSVRIFDVENE-NVLTD---------------------EDDSDGEN------------------- 1277

  Fly  2901 GLINQAPVQPAMPFANVVAMSPRAVTPTRTRTPTPTPAPTPPPPPPTPLLMQASPTATALHVNAC 2965
                                :.:..|||..::.|.||
 Worm  1278 --------------------TRKRKTPTSKKSVTSTP---------------------------- 1294

  Fly  2966 QSPPQQQHAQLMTMPSPPAIGVGTATNQMSPPPINIHAIQEAKEKLKQEKKEKHATKKLMKELAV 3030
                                    .||.:|..     .|...|||                 :.:
 Worm  1295 ------------------------TTNDISRV-----IIPNIKEK-----------------MTL 1313

  Fly  3031 CKTLLGEMELHEDSWPFLLPVNTKQFPTYRKIIKTPMDLSTIKKKLQDLSY----KTREDFCVDV 3091
            .:|||.|....|.|||||.||::|:.|.|..:||.||:|.|:..|::...|    :.|.||
 Worm  1314 IETLLKEAMRQECSWPFLQPVDSKEVPDYYDVIKRPMNLRTMMNKIKQRIYNKPIEVRNDF---- 1374

  Fly  3092 RQIFDNCEMFNEDDSPVGKAGHGMRKFFESRWGELTDK 3129
            :.|..|||.:||.::.:.|....:..|...|..|:.|:
 Worm  1375 QLILSNCETYNEPENEIYKLSRELHDFMADRLDEIIDQ 1412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tou	NP_001097270.1	HAT_MBD	953..1027	CDD:238691
		TPH	<1041..1228	CDD:464007
		PTZ00121	<1045..1681	CDD:173412	67/399 (17%)
		DDT	1255..1317	CDD:460696
		WSD	1700..>1726	CDD:464775	6/25 (24%)
		WSD	<2173..2222	CDD:464775	21/50 (42%)
		PHD_BAZ2A_like	2640..2685	CDD:277020	12/44 (27%)
		RanBP2-type Zn finger	2680..2698	CDD:275376	7/28 (25%)
		PHD	2695..2741	CDD:214584	5/59 (8%)
		Bromo_BAZ2A_B_like	3027..3123	CDD:99935	34/99 (34%)
athp-2	NP_494767.2	WAC_Acf1_DNA_bd	23..123	CDD:463140	18/101 (18%)
		DDT	457..524	CDD:214726	7/66 (11%)
		WHIM1	629..671	CDD:464774	6/41 (15%)
		WSD	795..897	CDD:464775	28/105 (27%)
		PHD	1100..1144	CDD:214584	15/172 (9%)
		BROMO	1306..1409	CDD:197636	38/123 (31%)