DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tou and Brd2

DIOPT Version :9

Sequence 1:	NP_001097270.1	Gene:	tou / 36241	FlyBaseID:	FBgn0033636	Length:	3131	Species:	Drosophila melanogaster
Sequence 2:	NP_001191902.1	Gene:	Brd2 / 14312	MGIID:	99495	Length:	798	Species:	Mus musculus

Alignment Length:	334	Identity:	89/334 - (26%)
Similarity:	136/334 - (40%)	Gaps:	90/334 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  2815 SSHDES------MNSLPAAPLSPAHSVVSATNYDDQHHANNSVDGSSRFHAHLIPPSNNGTAALL 2873
            :||.:.      ..|:.:|...||.|.||.|                   |...||....|..|
Mouse   193 NSHKKGAKLAALQGSITSAHQVPAVSSVSHT-------------------ALYTPPPEIPTTVL- 237

  Fly  2874 EDVPGGANVMPGVYPVYTPVAAGNFSAG----LINQAPVQPAMPFANVVAMSPRAVTPTRTRTPT 2934
             ::|     .|.|  :.:|:.....|||    .::.||  ||.|.|....:..:|    .|.|||
Mouse   238 -NIP-----HPSV--ISSPLLKSLHSAGPPLLAVSAAP--PAQPLAKKKGVKRKA----DTTTPT 288

  Fly  2935 PTP--APTPPPPPPTPLLMQASPTATALHVNACQSPPQQQHAQLMTMPSPPAIGVGTATNQMSPP 2997
            ||.  ||..|..||..|    .|.|..|       ||.::.                :...:.||
Mouse   289 PTAILAPGSPASPPGSL----EPKAARL-------PPMRRE----------------SGRPIKPP 326

  Fly  2998 PINIHAIQEAKEKLKQEKKEKHATK--KLMKELAVCKTLLGEM--ELHED-SWPFLLPVNTKQ-- 3055
                      ::.|...:::..::|  ||.::|..|..:|.|:  :.|.. :|||..||:...
Mouse   327 ----------RKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALG 381

  Fly  3056 FPTYRKIIKTPMDLSTIKKKLQDLSYKTREDFCVDVRQIFDNCEMFNEDDSPVGKAGHGMRKFFE 3120
            ...|..|||.||||||:|:|:::..|:..::|..|||.:|.||..:|..|..|......::..||
Mouse   382 LHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFE 446

  Fly  3121 SRWGELTDK 3129
            .|:.::.|:
Mouse   447 FRYAKMPDE 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tou	NP_001097270.1	HAT_MBD	953..1027	CDD:238691
		ZapA	1021..1127	CDD:294720
		MAP7	1043..1198	CDD:283355
		RILP-like	1085..>1179	CDD:304877
		DDT	1255..1317	CDD:280886
		WHIM1	1406..1455	CDD:292246
		WHIM3	2190..2224	CDD:292248
		PHD_BAZ2A_like	2640..2685	CDD:277020
		RanBP2-type Zn finger	2640..2659	CDD:275375
		RanBP2-type Zn finger	2680..2698	CDD:275376
		PHD	2695..2744	CDD:279022
		Bromo_BAZ2A_B_like	3027..3123	CDD:99935	35/100 (35%)
Brd2	NP_001191902.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..72
		Bromo_Brdt_I_like	73..179	CDD:99929
		PHA03247	<215..332	CDD:223021	45/187 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..348		29/123 (24%)
		Bromo_Brdt_II_like	348..449	CDD:99930	35/100 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	454..645		1/2 (50%)
		Nuclear localization signal. /evidence=ECO:0000255	553..557
		BET	639..701	CDD:407211
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	736..798
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900