DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tou and Crebbp

DIOPT Version :9

Sequence 1:NP_001097270.1 Gene:tou / 36241 FlyBaseID:FBgn0033636 Length:3131 Species:Drosophila melanogaster
Sequence 2:XP_006521814.1 Gene:Crebbp / 12914 MGIID:1098280 Length:2451 Species:Mus musculus


Alignment Length:2866 Identity:526/2866 - (18%)
Similarity:873/2866 - (30%) Gaps:982/2866 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   303 SMANNPGSAYDPVTLHKELLAMQAVAAAASGSGS---------SGSSGKKSGGGGSSSSSMHSLG 358
            |:.|:.....|..:.||:|..:     ...||||         |.||..:.|.||.:....:|..
Mouse    51 SLLNSGNLVPDAASKHKQLSEL-----LRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSTN 110

  Fly   359 MGIGGSGGM--MSSGKAST----SVSASNSSLGGMHPSLTSSNPLMSPHAGMGSSSSSSSK---- 413
            |...|:.|.  ::.|.:||    ..:||.|  |...|:..:.||......|:.:||.::|:    
Mouse   111 MASLGAMGKSPLNQGDSSTPNLPKQAASTS--GPTPPASQALNPQAQKQVGLVTSSPATSQTGPG 173

  Fly   414 -----DRDKNNPSLNALNSLS---------------QFGALGMT----------PQQSMQAAMNA 448
                 :.::.:|.|  |||.|               ..|:||..          |..:||.|.::
Mouse   174 ICMNANFNQTHPGL--LNSNSGHSLMNQAQQGQAQVMNGSLGAAGRGRGAGMPYPAPAMQGATSS 236

  Fly   449 FAAS--TGVSPSATVTSSPHHSSQQQQQMGG------NSSTSGSGK--SSSKDYMMGTGSEHPSL 503
            ..|.  |.|||...     .|:.....|.||      ..:||..|:  |.:....||....:|.|
Mouse   237 VLAETLTQVSPQMA-----GHAGLNTAQAGGMTKMGMTGTTSPFGQPFSQTGGQQMGATGVNPQL 296

  Fly   504 LGVR-----LPPDTEIIKYTSSIVGPKIPG-TTSRGRKKTISETEQQTTQQQQKQQHQAE----- 557
            ...:     ||.....||.||....|.:.. .||.|...|.:.....|...::::..|.:     
Mouse   297 ASKQSMVNSLPAFPTDIKNTSVTTVPNMSQLQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLL 361

  Fly   558 -QHLLQQQQQAQKELDSTKNAISSLLAFPGLSPAKRARLEMEYAAMAAAAQQQHQQAQQQ----- 616
             .|..|:::||..|:.:        .:.|.....|.....|.:.....|.|..|..:.:|     
Mouse   362 HAHKCQRREQANGEVRA--------CSLPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHW 418

  Fly   617 -----HQA--------------QQQLHGMLGAAGIPGMAGLVGLPGMSG------NPLDQLSVSK 656
                 |..              ||.:.|. .|:||....|.||....:.      ||:|..|:.:
Mouse   419 KNCTRHDCPVCLPLKNASDKRNQQTILGS-PASGIQNTIGSVGAGQQNATSLSNPNPIDPSSMQR 482

  Fly   657 ASSS------TAPTTSTSSSSAGS-----------NLLNQSNSDRVEV-------IKLPPTITSN 697
            |.::      ..|.|.......|.           ..||...::.:.:       .:.||.:.|.
Mouse   483 AYAALGLPYMNQPQTQLQPQVPGQQPAQPPAHQQMRTLNALGNNPMSIPAGGITTDQQPPNLISE 547

  Fly   698 GAYNLSSKGKEVHDLTTDMATNSGGVNLSLKSNAGSSALTPSGAVGSAS-------NPITID--- 752
            .|  |.:.....:.|..| .:|||        |.||.:..|:.|..|::       ..:|.|   
Mouse   548 SA--LPTSLGATNPLMND-GSNSG--------NIGSLSTIPTAAPPSSTGVRKGWHEHVTQDLRS 601

  Fly   753 ---------DFDAPLNLSMKPSDKSNSSSSNAAAGGSSSSSAALANLASDY-------------Q 795
                     .|..|...::|.....|..:......|....|   ||...:|             :
Mouse   602 HLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYES---ANSRDEYYHLLAEKIYKIQKE 663

  Fly   796 AASSGQSGNSLQSLSSITAALGGTGGM-----PGGSISGSGGTSPAPAGAGSGATGGGSGSGGSG 855
            .....:|....|.:.....||..:|..     |..|:....|..|.|......:.|..|.:    
Mouse   664 LEEKRRSRLHKQGILGNQPALPASGAQPPVIPPAQSVRPPNGPLPLPVNRMQVSQGMNSFN---- 724

  Fly   856 GGSSSYKEGRPRNLG-----------RGVSKPKKNTVASLLAQSRAVGLKPMLATQQLLQQGADI 909
                      |.:||           |..|....:...:.:|....:.:.|....|.....|...
Mouse   725 ----------PMSLGNVQLPQAPMGPRAASPMNHSVQMNSMASVPGMAISPSRMPQPPNMMGTHA 779

  Fly   910 EKIRLALSEANAHM-----ETSTDSESV--------AAESGLSESESEDA---NILNVAELRV-- 956
            ..|.......|..:     .:|:.:.||        ||::|:|:.:...|   |.||:...:.  
Mouse   780 NNIMAQAPTQNQFLPQNQFPSSSGAMSVNSVGMGQPAAQAGVSQGQVPGAALPNPLNMLAPQASQ 844

  Fly   957 ----PLELGWKRETVIRGLTKQG--QIRGEVTYYAPGST------------------TPLKSNGQ 997
                |:.......|.....|..|  .::...   |||.|                  ||..:.|.
Mouse   845 LPCPPVTQSPLHPTPPPASTAAGMPSLQHPT---APGMTPPQPAAPTQPSTPVSSGQTPTPTPGS 906

  Fly   998 VFAILEQQPSNLSRENFSFSARAIVGSFLQ-PAPPPYANDGEYIRMTDEDVAKRLEDLKVFTRQT 1061
            |.:..:.|    |......:|:|.|....| |..||.....:..:.....|..:.....: ::..
Mouse   907 VPSAAQTQ----STPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHTQPPGTPL-SQAA 966

  Fly  1062 LNVEQRI---------EIAKQQQA----MRDAK-KLQKEELARNKEKARQEKNSKL--EQQRKDK 1110
            .:::.|:         |.:.||..    |.:.| ::|.::......:::.|..|::  |..:...
Mouse   967 ASIDNRVPTPSSVTSAETSSQQPGPDVPMLEMKTEVQTDDAEPEPTESKGEPRSEMMEEDLQGSS 1031

  Fly  1111 ELKNQQAVEERKKRQEELDRLKQEELLKKQQEKEKRRQEAILAKEQELQKQKEMLLAAEMERERR 1175
            ::|.:....|:|....|::..|.|..::.::|:|....:.........|.:|::....|:.:   
Mouse  1032 QVKEETDTTEQKSEPMEVEEKKPEVKVEAKEEEENSSNDTASQSTSPSQPRKKIFKPEELRQ--- 1093

  Fly  1176 RQHMSLIRMLELRRKFEDREKKKHQLVLDRLLLRERRMAERKRDAEILQLIRRPNEDSEMPQELV 1240
                :|:..||                           |..::|.|.|. .|:|.:    ||.|.
Mouse  1094 ----ALMPTLE---------------------------ALYRQDPESLP-FRQPVD----PQLLG 1122

  Fly  1241 IPELDRIAGNRL----------------PGQAMADLLMVFE--FLHNFGETLGFDMESLPSLQNL 1287
            ||:...|..|.:                |.|.:.|:.::|.  :|:|...:..:...|     .|
Mouse  1123 IPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCS-----KL 1182

  Fly  1288 HDALMSDSNADAEEELLSVMTHLLVCAIEDPGVPNPGRHTTLLGQSLRNADITNSNVSEILRIYL 1352
            .:..        |:|:..||..|..|.         ||......|:|.........:......|.
Mouse  1183 AEVF--------EQEIDPVMQSLGYCC---------GRKYEFSPQTLCCYGKQLCTIPRDAAYYS 1230

  Fly  1353 YATATGEVRQMHGITVDRERERRVPDHH--------------QLDSDTTTHSHSVKNQEYYKLLH 1403
            |..::.:    :|:..||        :|              .|..|.:....::...::.|  .
Mouse  1231 YQNSSPK----YGLLADR--------YHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEK--K 1281

  Fly  1404 ENDTWKLSQSLKDRPFVALNPT-RKAQMLAHLCNDLLMNKAVLRQIDGSLETCAQMRKEKYMTDM 1467
            :|||      |...|||..... ||...:..|..|::.....:  .|..|:...:.|||...:..
Mouse  1282 KNDT------LDPEPFVDCKECGRKMHQICVLHYDIIWPSGFV--CDNCLKKTGRPRKENKFSAK 1338

  Fly  1468 KVRKYKALHMRKARIEAYERAQAEREAAMQALMAQQKLDAERLKAEEEAKAAAAEEAAAAAGTDG 1532
            :::..:..:..:.|:..:.|.|...||....:         |:.|..: |....:....:...| 
Mouse  1339 RLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFV---------RVVASSD-KTVEVKPGMKSRFVD- 1392

  Fly  1533 EATKGGSPNGEKPEDGDQNEEGA-AKEPQQQQQQPMEVDGV--------VDEASLVSPAKTIIQT 1588
                    :||..|......:.. |.|         |:|||        |.|..           
Mouse  1393 --------SGEMSESFPYRTKALFAFE---------EIDGVDVCFFGMHVQEYG----------- 1429

  Fly  1589 DNSLTPSKQDMPTPTYQINGSSTPTTSGVTGGDMNVLLQAKKSGARNSINDEHHHDVSIIDDDLS 1653
                    .|.|          .|.|..|....::.:...:....|.::    :|::.|      
Mouse  1430 --------SDCP----------PPNTRRVYISYLDSIHFFRPRCLRTAV----YHEILI------ 1466

  Fly  1654 DLDSEITNVEEDEDNRLSADELQKKLDKIVRASLNCKEALEKSTNQLRAACFGQDRFWRRYWKLP 1718
                             ...|..|||..:......|..:   ..:.....|...|:      |:|
Mouse  1467 -----------------GYLEYVKKLGYVTGHIWACPPS---EGDDYIFHCHPPDQ------KIP 1505

  Fly  1719 KAGGIFIEALESAQNDICDYHEALEAMDDKKD----ANDEKENSENE---------KDVAAESSE 1770
            |.     :.|:.....:.|...|...::|.||    ||:::..|..|         .:|..||.:
Mouse  1506 KP-----KRLQEWYKKMLDKAFAERIINDYKDIFKQANEDRLTSAKELPYFEGDFWPNVLEESIK 1565

  Fly  1771 QPMEVDESITKLEDGVPASDVGMPESNQ---QNA----HQDEEDDDDDVTEINKVEPEIVDLGDD 1828
            : :|.:|...|.|:...||:.  ||.:|   :||    ::....:...::..||.:|.:.::.:|
Mouse  1566 E-LEQEEEERKKEESTAASET--PEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSND 1627

  Fly  1829 DDDAAPPLPKIEPPRPEIKVKSEMEL-----------MGPPPTTMISTKTDFEAEIKIPSMPGIL 1882
            ...               |:.:.||.           .||    :|||:            |.|:
Mouse  1628 LSQ---------------KLYATMEKHKEVFFVIHLHAGP----VISTQ------------PPIV 1661

  Fly  1883 MP-PTLNNNNTNNNNNNNGSDNCDKLETGLGLGQQQQNFSQSVIKTEDVKKEDDCIIVSTSSVDD 1946
            .| |.|:            .|..|..:..|.|.:.:.                            
Mouse  1662 DPDPLLS------------CDLMDGRDAFLTLARDKH---------------------------- 1686

  Fly  1947 TPKW-FSIVRRE----VPLISELPAEEGGVVGQELQISYANQNCSAQLQLQGH-----PWDLINN 2001
               | ||.:||.    :.::.||..:     ||: :..|....|...::.:.|     .:||..|
Mouse  1687 ---WEFSSLRRSKWSTLCMLVELHTQ-----GQD-RFVYTCNECKHHVETRWHCTVCEDYDLCIN 1742

  Fly  2002 MQYYSIPMDECKVDTSKLGNECIFSLSGLDEKQMLAKVEEYKAHKVESKNGLGSPHRHHETKDDE 2066
            ..       ..|..|.|:....:    |||::                    ||.....::|..:
Mouse  1743 CY-------NTKSHTHKMVKWGL----GLDDE--------------------GSSQGEPQSKSPQ 1776

  Fly  2067 EQAKLKLDKEIDTEMET----DAD-DLAGKEKFFRL---RSDVPPDTGGG--------------- 2108
            |..:|.:.:.|.:.:..    :|: .|...:|..|:   .......|.||               
Mouse  1777 ESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHA 1841

  Fly  2109 ---------VSEGTDVKPK-----IELRLDEA------LSQAYYHNIANMSL------------- 2140
                     |....::|.|     |:.||.:|      ::.....|:...||             
Mouse  1842 KHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQ 1906

  Fly  2141 --SSVQTYIP--IDIPLPLSMTPDEHRLLEQVKLAGFPERVHGVYVPRRQRYGWWQLDDEQKLRQ 2201
              |:.||..|  ...|.|::|:|           ||||.      |.|.|         ...:..
Mouse  1907 QPSTPQTPQPPAQPQPSPVNMSP-----------AGFPN------VARTQ---------PPTIVS 1945

  Fly  2202 LLKTLN------------PSGL-------RERELQENLQRF------------LGLE----QPLG 2231
            ..|..|            |:.:       ||.:.|::|.|.            :|..    .|:|
Mouse  1946 AGKPTNQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRANINNGMPPGRAGMGTPGSQMTPVG 2010

  Fly  2232 VNYKLKSDIDFPEEFLMPDKKGDWN--PKVAKRVELALIEQLESLEDKVASASMQLKNWQLPNRV 2294
            :|....:.:..|....||  .|.|.  |...::....:...:.|::.:.|.|..::.|.|.|..:
Mouse  2011 LNVPRPNQVSGPVMSSMP--PGQWQQAPIPQQQPMPGMPRPVMSMQAQAAVAGPRMPNVQPPRSI 2073

  Fly  2295 ESEL------TLDSQEDVTEEDFVSII---------PMIRERIIDLEANIERRYLKPPLGSQTG- 2343
            ....      ||.|.....::..|..|         ..|::|.....||......:|.|.||.| 
Mouse  2074 SPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGM 2138

  Fly  2344 ----DAHLAVIAQNQH---------------------------------------TTTQTQNSAS 2365
                ..|.....||.:                                       |....|....
Mouse  2139 QPQPGMHQQPSLQNLNAMQAGVPRPGVPPPQPAMGGLNPQGQALNIMNPGHNPNMTNMNPQYREM 2203

  Fly  2366 AAAYLLQMQQQQQQQQLAQQQQQQQQGSGAGNSLNPSSFNERTMALAAAAAASGPGNATGVANSA 2430
            ....|||.|||||||| .||||||...|.||.....|.|.:          ..|||.........
Mouse  2204 VRRQLLQHQQQQQQQQ-QQQQQQQNSASLAGGMAGHSQFQQ----------PQGPGGYAPAMQQQ 2257

  Fly  2431 VVAGATPCESGS--------------GEPNSGNASPASNCDSDRDEKVEQIPKGLVQWRDAVSRS 2481
            .:....|.:..|              |:|..|         :|....::|               
Mouse  2258 RMQQHLPIQGSSMGQMAAPMGQLGQMGQPGLG---------ADSTPNIQQ--------------- 2298

  Fly  2482 HTTAQLAMALYVLESCVAWDKSIMKAYATKNKSSKKKSSAKKQATPSKKQQ-------QKKNKKE 2539
                  |:...:|:                .:..|::..:..|..|...||       |..:...
Mouse  2299 ------ALQQRILQ----------------QQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPG 2341

  Fly  2540 QQL-TPNGKESKSKSAINKPENQAPLSIKINLKALAQNGQCLLKTKTPPILTKSPTASP------ 2597
            ||: |....:.:|.:.:..|..|:                      .||..:.||...|      
Mouse  2342 QQIATSLSNQVRSPAPVQSPRPQS----------------------QPPHSSPSPRIQPQPSPHH 2384

  Fly  2598 ------SSHPN---TSDSDSDFGKRTKKKSGGKRRRSA-----NNTNSSKYSNSLQNCQFCTSGE 2648
                  |.||.   |..|..|.|..      |...:||     |..|.|..|:.| :....|:|:
Mouse  2385 VSPQTGSPHPGLAVTMASSMDQGHL------GNPEQSAMLPQLNTPNRSALSSEL-SLVGDTTGD 2442

  Fly  2649 NEDKLL 2654
            ..:|.:
Mouse  2443 TLEKFV 2448

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
touNP_001097270.1 HAT_MBD 953..1027 CDD:238691 17/99 (17%)
ZapA 1021..1127 CDD:294720 19/122 (16%)
MAP7 1043..1198 CDD:283355 25/170 (15%)
RILP-like 1085..>1179 CDD:304877 14/95 (15%)
DDT 1255..1317 CDD:280886 13/63 (21%)
WHIM1 1406..1455 CDD:292246 12/49 (24%)
WHIM3 2190..2224 CDD:292248 8/64 (13%)
PHD_BAZ2A_like 2640..2685 CDD:277020 3/15 (20%)
RanBP2-type Zn finger 2640..2659 CDD:275375 3/15 (20%)
RanBP2-type Zn finger 2680..2698 CDD:275376
PHD 2695..2744 CDD:279022
Bromo_BAZ2A_B_like 3027..3123 CDD:99935
CrebbpXP_006521814.1 zf-TAZ 362..429 CDD:366931 13/74 (18%)
KIX 586..666 CDD:366953 11/82 (13%)
PHA03247 <687..1037 CDD:223021 63/371 (17%)
COG5076 942..>1194 CDD:227408 48/304 (16%)
Bromo_cbp_like 1088..1195 CDD:99927 28/158 (18%)
RING_CBP-p300 1207..1289 CDD:276805 15/101 (15%)
PHD_CBP_p300 1291..1322 CDD:277032 7/32 (22%)
HAT_KAT11 1353..>1564 CDD:369758 49/308 (16%)
ZZ_CBP 1716..1756 CDD:239077 9/46 (20%)
ZnF_TAZ 1777..1855 CDD:214717 11/77 (14%)
Med15 1971..>2422 CDD:312941 101/537 (19%)
Creb_binding 2045..2125 CDD:370251 15/79 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5076
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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