Protein Alignment tou and Baz2a

DIOPT Version :10

• Sequence 1: NP_001097270.1
• Gene: tou / 36241
• FlyBaseID: FBgn0033636
• Length: 3131
• Species: Drosophila melanogaster
• Sequence 2: XP_011241580.1
• Gene: Baz2a / 116848
• MGIID: 2151152
• Length: 1888
• Species: Mus musculus
• Alignment Length: 2967
• Identity: 576/2967 - (19%)
• Similarity: 929/2967 - (31%)
• Gaps: 1271/2967 - (42%)

  Fly   328 AAAASGSGSSGSSGKKSGGGGSSSSSMHSLGMGIGGSGGMMSSGKASTSVSASNSSLGGMHPSLT 392
            |.||||...|.|||:   |..::.|.|:....|...:|.:..:|.::.|.:.::..|... |..:
Mouse    15 APAASGLKPSPSSGE---GLYTNGSPMNFPQQGKSLNGDVNVNGLSTVSHTTTSGILNSA-PHSS 75

  Fly   393 SSNPLMSPHAGMG-----SSSSSSSKDRDKNNPSLNALNSLSQFGALGMTPQQSMQAAMNAFAAS 452
            |::.|..|:....     |...|::...:..:|.|     ||||.. |..|       :|
Mouse    76 STSHLHHPNVAYDCLWNYSQYPSANPGNNLKDPPL-----LSQFPG-GQYP-------LN----- 122

  Fly   453 TGVSPSATVTSSPHHSS-----QQQQQMGGNSSTSGSGKSSSKDY---------MMGTGSEHPSL 503
             |:.......|||.|::     .|:....|..|..|....|.:.|         :|..|
Mouse   123 -GILGGNRQPSSPSHNTNLRAGSQEFWANGTQSPMGLNFDSQELYDSFPDQNFEVMPNG------ 180

  Fly   504 LGVRLPPDTEIIKYTSSIVGPKIPGTTSRGRKKTISETEQQTTQQQQKQQHQAEQHLLQQQQQAQ 568
                 ||.......||.::|..|         :|.:.::..::.             :...:.|:
Mouse   181 -----PPSFFTSPQTSPMLGSSI---------QTFAPSQDVSSD-------------IHPDEAAE 218

  Fly   569 KELDSTKNAISSLLAFPGLSPAKRARLEME--------YAAMAAAAQQQHQQA------------ 613
            |||       :|::|..|........||.|        |....::.:..||:.
Mouse   219 KEL-------TSVVAENGTGLVGSLELEEEQPELKMCGYNGSVSSVESLHQEVSVLVPDPTVSCL 276

  Fly   614 -QQQHQAQQ-------------QLHGMLGAAGIPGM------AGLVG----LPGMSGNP-LDQLS 653
             ...|...|             ....:..|..:.|.      |.|:|    || :.||| :..|.
Mouse   277 DDPSHLPDQLEDTPILSEDSLEPFDSLAAAEPVSGSLYGIDDAELMGAEDKLP-LEGNPVISALD 340

  Fly   654 VSKASSSTAPTTSTSSSSAGSNLLNQSNSDRVEVIKLPPTITSNGAYNLSSKGKEVHDLTTDMAT 718
            ....|::.|.:.....|...:::.....|        ||.:           |:.|      :..
Mouse   341 CPALSNANAFSLLADDSQTSASIFVSPTS--------PPVL-----------GESV------LQD 380

  Fly   719 NSGGVNLSLKSNAGSSALTPSGAVGSASNPITIDDFDAPLNLSMKPSDKSNSSSSNAAAGGSSSS 783
            ||.|:| |...:......|.|   .:...|:|....|.|.:..:.|: .|.::|..|:...|:..
Mouse   381 NSFGLN-SCSDSEQEEIETQS---SNFQRPLTEPAPDQPPSTQLHPA-VSPTASPAASLTASAEI 440

  Fly   784 SAALANLAS-----DYQAASSGQSGNSLQSLS---SITAALGGTGGMPGGSISGSGGT-SPAPAG 839
            |.|::.:||     :...|.|..|..:|.::|   |:|..:....|.|..|.:.:..| |||...
Mouse   441 SPAVSPVASSPVPPEVFVAVSPASSPALPAISLEASMTTPVTSPQGSPEPSPAAAFQTVSPARKN 505

  Fly   840 AGSG---------ATGGGSGSGGSGGGSSSYKEGRPRNLGRGVSKPKKNTVASLLAQSRAVGLKP 895
            ..|.         .|||.....|||
Mouse   506 VSSAPKARADREETTGGAVAVSGSG---------------------------------------- 530

  Fly   896 MLATQQLLQQGADIEKIRLALSEANAHMETSTDSESVAAESGLSESESEDANILNVAELRVPLEL 960
                        |:.|.|:|..|                                  |:|:||:.
Mouse   531 ------------DVLKRRIATPE----------------------------------EVRLPLQH 549

  Fly   961 GWKRETVIRGLTKQGQIR--GEVTYYAPGSTTPLKSNGQVFAILEQQ-PSNLSRENFSFSARAIV 1022
            ||:||..|    |:|..|  ||..||.|.... :|...:|...|.:. ..::.||:||||.|..|
Mouse   550 GWRREVRI----KKGSHRWQGETWYYGPCGKR-MKQFPEVIKYLSRNVVHSVRREHFSFSPRMPV 609

  Fly  1023 GSFLQPAPPPYANDG-EYIRMTDEDVAKRLEDLKVFTRQTLNVE--QRIEIAKQQQAM------- 1077
            |.|.:....|   :| ::::::.|::..|::.:.....:..|.|  :..|:.|.::..
Mouse   610 GDFFEERDTP---EGLQWVQLSAEEIPSRIQAITGKRGRPRNNEKAKNKEVPKVKRGRGRPPKIK 671

  Fly  1078 ----------RDAKKLQKEELARNKEKARQEKNSKLEQQRKDK-ELKNQQAVEERKKRQEELDRL 1131
                      |..|||:.:|:....:||:..||.|..:|:..: |.:.....:.|.||:::...|
Mouse   672 MPELLNKTDNRLPKKLETQEILSEDDKAKMTKNKKKMRQKVQRGESQTPVQGQARNKRKQDTKSL 736

  Fly  1132 KQEEL---LKKQQEKEKRRQEAILAKEQELQKQKEMLLAAEMERERRRQHMSLIRMLELRRKFED 1193
            ||::.   ||.::||.|.:||.:  ||:..:::||.:.|...|..|.|....
Mouse   737 KQKDTKKKLKAEKEKMKTKQEKL--KEKVKREKKEKVKAKGKEGPRARPSCR------------- 786

  Fly  1194 REKKKHQLVLDRLLLRERRMAERKRDAEILQLIRRPNEDSEMPQELVIPELDRIAGNRLPGQAMA 1258
                     .|:.|..::|:.|::|...||:.:::|.||..:.....:|:..||.|..|..:|.:
Mouse   787 ---------ADKTLATQKRLEEQQRQQAILEEMKKPTEDMCLSDHQPLPDFTRIPGLTLSSRAFS 842

  Fly  1259 DLLMVFEFLHNFGETLGFDM-ESLPSLQNLHDALMSDSNADAEEELLSVMTHLLVCAIEDPGVPN 1322
            |.|.:.||||:||:.||||: :.:|||..|.:.|:  ...|:.:::..::..||..|:.|||:|.
Mouse   843 DCLTIVEFLHSFGKVLGFDLTKDVPSLGVLQEGLL--CQGDSLDKVQDLLVRLLKAALHDPGLPP 905

  Fly  1323 PGRHTTLLGQSLRNADITNSNVSEILRIYLYATATGEVRQMHGITVDRERERRVPDHHQLDSDTT 1387
            ..:...:||:.:....:|..|||||||.:|.|
Mouse   906 YCQSLKILGEKMSEIPLTRDNVSEILRCFLMA--------------------------------- 937

  Fly  1388 THSHSVKNQEYYKLLHENDTWKLSQSLKDRPFVALNPTRKAQMLAHLCNDLLMNKAVLRQIDGSL 1452
                       |::     ......||:.:||.|..|.:||.:||.|.::|..:..::.:||.:|
Mouse   938 -----------YRV-----EPSFCDSLRTQPFQAQPPQQKAAILAFLVHELNSSTIIINEIDKTL 986

  Fly  1453 ETCAQMRKEKYMTDMKVRKYKALHMRKARIEAYERAQAEREAAMQALMAQQKLDAERLKAEEEAK 1517
            |:.:..||.|::.:.::|:.|.             |.|:|....:.:|
Mouse   987 ESVSSCRKNKWIVEGRLRRLKT-------------ALAKRTGRPEVMM----------------- 1021

  Fly  1518 AAAAEEAAAAAGTDGEATKGGSPNGEKPEDGDQNEEGAAKEPQQQQQQPMEVDGVVDEASLVSPA 1582
                 |.|                          |:|..:....:..:  |..|:.:|.
Mouse  1022 -----EGA--------------------------EDGLGRRRSSRIME--ETSGIEEEE------ 1047

  Fly  1583 KTIIQTDNSLTPSKQDMPTPTYQINGSSTPTTSGVTGGDMNVLLQAKKSGARNSINDEHHHDVSI 1647
                :.:|                       |:.|.|      .:.:|.|
Mouse  1048 ----EEEN-----------------------TTAVHG------RRGRKEG--------------- 1064

  Fly  1648 IDDDLSDLDSEITNVEEDEDNRLSADELQKKLDKIVRASLNCKEALEKSTNQLRAACFGQDRFWR 1712
                  ::|...:::          .||::.::|:.:..|..::.|..|:..|||...||||:.|
Mouse  1065 ------EIDVAASSI----------PELERHIEKLSKRQLFFRKKLLHSSQMLRAVSLGQDRYRR 1113

  Fly  1713 RYWKLPKAGGIFIEALESAQNDICDYHEALEAMDDKKDANDE-KENSENEKDVAAESSEQPMEVD 1776
            .||.||...|||:|..|.:                 ....|| |:.:|:..:|...:   |....
Mouse  1114 HYWVLPYLAGIFVEGSEGS-----------------TVTEDEIKQETESLMEVVTST---PSSAR 1158

  Fly  1777 ESITKLEDG-----VPASDVGMPESNQQNAHQDE-------EDDDDDVTEINKVEPEIVDLGDDD 1829
            .|:.:...|     .||...|.|...:..:.|.:       |.|.:...  .:|.||
Mouse  1159 ASVKRELTGSNASTSPARSRGRPRKPKPGSLQPQHLQSTIRECDSEQAQ--TQVHPE-------- 1213

  Fly  1830 DDAAPPLPKIE-PPRPEIKVKSEMELMGPPPTTMISTKTDFEAEIKIPSMPGILMPPTLNNNNTN 1893
                 |.|::: |.:|.::..|                             |.|.|
Mouse  1214 -----PQPQLQAPTQPHLQPSS-----------------------------GFLEP--------- 1235

  Fly  1894 NNNNNNGSDNCDKLETGLGLGQQQQNFSQSVIKTEDVKKEDDCIIVSTSSVDDTPKWFSIVRREV 1958
                 .||.        ..|||.|.:.|||..               .|.:..|....|::...|
Mouse  1236 -----EGSP--------FSLGQSQHDLSQSAF---------------LSWLSQTQSHNSLLSSSV 1272

  Fly  1959 PLISELPAEEGGVVGQELQISYAN--QNCSAQLQLQGHPWDLINNMQYYSIPMDECKVDTSKLGN 2021
            ......|.:......|.|:....:  |:|...   || ||...:    ..||.|
Mouse  1273 LTPDSSPGKLDSAPSQSLEEPEPDEAQSCPGP---QG-PWFNFS----AQIPCD----------- 1318

  Fly  2022 ECIFSLSGLDEKQMLAKVEEYKAHKVESKNGLGSPHRHHETKDDEEQAKLKLDKEIDTEMETDAD 2086
                                            .:|.......:|:....|:|
Mouse  1319 --------------------------------AAPTPPPAVSEDQPTPSLQL------------- 1338

  Fly  2087 DLAGKEKFFRLRSDVPPDTGGGVSEGTDVKPKIELRLDEALSQAYYHNIANMSLSSVQTYIPIDI 2151
                      |.|..|.:|.|..:..:.|:                       |||  |::|...
Mouse  1339 ----------LASSKPMNTPGAANPCSPVQ-----------------------LSS--THLPGGT 1368

  Fly  2152 PLPLSMTPDEHRL----LEQVKLAGFP-----ERVHGVY--------VPRRQRYGWWQLDDEQKL 2199
            |..||...:|...    |.|.|..|.|     ::|...|        :|.....|||.:.|.:.|
Mouse  1369 PKRLSGDSEEMSQSPTGLGQPKRRGRPPSKFFKQVEQHYLTQLTAQPIPPEMCSGWWWIRDPETL 1433

  Fly  2200 RQLLKTLNPSGLRERELQENLQR---FLG--LEQPLGVNYKLKSDIDFPEEFLMPDKKGDWNPK- 2258
            ..|||.|:|.|:||:.|.::|.:   ||.  ..|||.......:::...||.:|     .|:||
Mouse  1434 DVLLKALHPRGIREKALHKHLSKHKDFLQEVCLQPLTDPIFEPNELPALEEGVM-----SWSPKE 1493

  Fly  2259 VAKRVELALIEQLESLEDKVASASMQLKNW--QLPNRVESELTL-----DSQED----------- 2305
            .....:||:::.:|.||.:|..:.:|::.|  ..|:....:||.     ||.||
Mouse  1494 KTYETDLAVLQWVEELEQRVVLSDLQIRGWTCPTPDSTREDLTYCEHLPDSPEDIPWRGRGREGT 1558

  Fly  2306 VTEEDFVSIIPMIRERIIDLEANIERRYLKPPLGSQTGDAHLAVIAQNQHTTTQTQNSASAAAYL 2370
            |.:....:.:.:...|:..||.|:|||||:.||.:    ||..|:.:
Mouse  1559 VPQRQNNNPLDLAVMRLAVLEQNVERRYLREPLWA----AHEVVVEK------------------ 1601

  Fly  2371 LQMQQQQQQQQLAQQQQQQQQGSGAGNSLNPSSFNERTMALAAAAAASGPGNATGVANSAVVAGA 2435
                                                   ||.:....:..|.:|.::
Mouse  1602 ---------------------------------------ALLSTPNGAPDGTSTEIS-------- 1619

  Fly  2436 TPCESGSGEPNSGNASPASNCDSDRDEKVEQIPKGLVQWRDAVSRSHTTAQLAMALYVLESCVAW 2500
                                        .|..|:..| ||..:.|..:.||:.:.:..||..:||
Mouse  1620 ----------------------------YEITPRVRV-WRQTLERCRSAAQVCLCMGQLERSIAW 1655

  Fly  2501 DKSIMKAYATKNKSSKKKSSAKKQATPSKKQQQKKNKKEQQLTPNGKESKSKSAINKPENQAPLS 2565
            :||:.|.
Mouse  1656 EKSVNKV---------------------------------------------------------- 1662

  Fly  2566 IKINLKALAQNGQCLLKTKTPPILTKSPTASPSSHPNTSDSDSDFGKRTKKKSGGKRRRSANNTN 2630
                                                                             
Mouse  1663 ----------------------------------------------------------------- 1662

  Fly  2631 SSKYSNSLQNCQFCTSGENEDKLLLCDGCDKGYHTYCFKPKMDNIPDGDWYCYECVNKATNERKC 2695
                     .|..|..|:|::.||||||||:|.|.||.:|||:.:|:|||:|..|:::...|.
Mouse  1663 ---------TCLVCRKGDNDEFLLLCDGCDRGCHIYCHRPKMEAVPEGDWFCAVCLSQQVEEE-- 1716

  Fly  2696 IVCGGHRPSPVGKMIYCDLCPRAYHADCYIPPLLKVPRGKWYCHGCISRAPPPKKRSAGGTSGSS 2760
                                                          .::.|...||
Mouse  1717 ----------------------------------------------YTQRPGFPKR--------- 1726

  Fly  2761 SKSRRDRDRESGGSAKRRSDNSKTPAMEHMQQQQMPLA--GGDSHHHHHQQPPSLNSSHDESMNS 2823
                         ..||:|              ..||.  .|||...      .|:.|.|.
Mouse  1727 -------------GQKRKS--------------SFPLTFPEGDSRRR------MLSRSRDS---- 1754

  Fly  2824 LPAAPLSPAHSVVSATNYDDQHHANNSVDGSSRFHAHLIPPSNNGTAALLEDVPGGANVMPGVYP 2888
             ||.|..|.                   ||
Mouse  1755 -PAVPRYPE-------------------DG----------------------------------- 1764

  Fly  2889 VYTPVAAGNFSAGLINQAPVQPAMPFANVVAMSPRAVTPTRTRTPTPTPAPTPPPPPPTPLLMQA 2953
                                                                             
Mouse  1765 ----------------------------------------------------------------- 1764

  Fly  2954 SPTATALHVNACQSPPQQQHAQLMTMPSPPAIGVGTATNQMSPPPINIHAIQEAKEKLKQEKKEK 3018
                                                    :|||                 |:.:
Mouse  1765 ----------------------------------------LSPP-----------------KRRR 1772

  Fly  3019 HATKKLMKELAVCKTLLGEMELHEDSWPFLLPVNTKQFPTYRKIIKTPMDLSTIKKKLQDLSYKT 3083
            |:.:....:|..|:.:|.|||.|:.:||||.|||.:....||::||.|||.||::::|....|.:
Mouse  1773 HSMRSHHSDLTFCEIILMEMESHDAAWPFLEPVNPRLVSGYRRVIKNPMDFSTMRERLLRGGYTS 1837

  Fly  3084 REDFCVDVRQIFDNCEMFNEDDSPVGKAGHGMRKFFESRWGE 3125
            .|:|..|...:||||:.||||||.||||||.||:||||||.|
Mouse  1838 SEEFAADALLVFDNCQTFNEDDSEVGKAGHVMRRFFESRWEE 1879

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tou	NP_001097270.1	HAT_MBD	953..1027	CDD:238691	30/76 (39%)
		TPH	<1041..1228	CDD:464007	46/209 (22%)
		PTZ00121	<1045..1681	CDD:173412	134/659 (20%)
		DDT	1255..1317	CDD:460696	22/62 (35%)
		WSD	1700..>1726	CDD:464775	15/25 (60%)
		WSD	<2173..2222	CDD:464775	19/61 (31%)
		PHD_BAZ2A_like	2640..2685	CDD:277020	24/44 (55%)
		RanBP2-type Zn finger	2680..2698	CDD:275376	4/17 (24%)
		PHD	2695..2741	CDD:214584	0/45 (0%)
		Bromo_BAZ2A_B_like	3027..3123	CDD:99935	50/95 (53%)
Baz2a	XP_011241580.1	PHA03307	269..>517	CDD:223039	56/278 (20%)
		PRK07003	<408..>534	CDD:235906	34/178 (19%)
		HAT_MBD	542..614	CDD:238691	30/76 (39%)
		DDT	840..902	CDD:214726	23/63 (37%)
		WSD	1101..>1131	CDD:464775	16/29 (55%)
		Atrophin-1	1129..>1421	CDD:460830	79/491 (16%)
		WSD	<1424..1458	CDD:464775	14/33 (42%)
		PHD_BAZ2A	1663..1709	CDD:277099	24/45 (53%)
		Bromo_BAZ2A_B_like	1781..1877	CDD:99935	50/95 (53%)