DRSC/TRiP Functional Genomics Resources

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Protein Alignment tou and Aire

DIOPT Version :9

Sequence 1:NP_001097270.1 Gene:tou / 36241 FlyBaseID:FBgn0033636 Length:3131 Species:Drosophila melanogaster
Sequence 2:NP_033776.1 Gene:Aire / 11634 MGIID:1338803 Length:552 Species:Mus musculus


Alignment Length:561 Identity:115/561 - (20%)
Similarity:180/561 - (32%) Gaps:213/561 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly  2513 KSSKKKSSAKKQATPSKKQQQKKNKKEQQLTPNGKESKSKSAINKPENQAPLSIKINLKALAQNG 2577
            |..|..:..|....|.:...::|..:|.:.||  ..:.:..:::.|.:.                
Mouse   112 KGRKPLAGPKAAVLPPRPPTKRKALEEPRATP--PATLASKSVSSPGSH---------------- 158

  Fly  2578 QCLLKTKTP------------PI----------LTKSPTASPSSHPNTSDSDSDF-------GKR 2613
               ||||.|            |:          :.::.|.:....|.|..:....       ..|
Mouse   159 ---LKTKPPKKPDGNLESQHLPLGNGIQTMAASVQRAVTVASGDVPGTRGAVEGILIQQVFESGR 220

  Fly  2614 TKK--KSGGK-------RRRSANNTNSSKYSNSL------QNCQFCTSGENEDKLLLCDGCDKGY 2663
            :||  :.||:       ...|.|..|.::..:||      :..|....|.:|.|:          
Mouse   221 SKKCIQVGGEFYTPNKFEDPSGNLKNKARSGSSLKPVVRAKGAQVTIPGRDEQKV---------- 275

  Fly  2664 HTYCFKPKMDNIPDGDWYCYECVNKATNERKCIVCGGHRPSPVGKMIYCDLCPRAYHADCYIPPL 2728
            ...|..|.:.::|....     ||: .||.:|.||     ...|::|.||.||||:|..|..|||
Mouse   276 GQQCGVPPLPSLPSEPQ-----VNQ-KNEDECAVC-----HDGGELICCDGCPRAFHLACLSPPL 329

  Fly  2729 LKVPRGKWYCHGC-------------ISRAP--PPKKRSAGGTSGSSSKSRRDRDRESGGSAKRR 2778
            .::|.|.|.|..|             :||.|  |.:.....|...:|.|:|       |.|.:.:
Mouse   330 QEIPSGLWRCSCCLQGRVQQNLSQPEVSRPPELPAETPILVGLRSASEKTR-------GPSRELK 387

  Fly  2779 SDNSKTPAMEHMQQQQMPLAGGDSHHHHHQQPPSLNSSHDESMNSLPAAPLSPAHSVVSATNYDD 2843
            :  |...|:.::                     :|.:.|       ||||               
Mouse   388 A--SSDAAVTYV---------------------NLLAPH-------PAAP--------------- 407

  Fly  2844 QHHANNSVDGSSRFHAHLIPPSNNGTAALLEDVPGGANVMPGVYPVYTPVAAGNFSAGLINQA-- 2906
                             |:.||     ||...:..|....||..|.......|: ...::..|  
Mouse   408 -----------------LLEPS-----ALCPLLSAGNEGRPGPAPSARCSVCGD-GTEVLRCAHC 449

  Fly  2907 ----------PVQPAMPFANVVAMSPRAVTPTRTRTPTP-TP---APTPPPPPPTPLLMQASPTA 2957
                      |...|.|..|:     |..:.:...|||| ||   .||..|.|...|......:|
Mouse   450 AAAFHWRCHFPTAAARPGTNL-----RCKSCSADSTPTPGTPGEAVPTSGPRPAPGLAKVGDDSA 509

  Fly  2958 T---ALHVNACQSPPQQQHA---------QLMTMP---SPP 2983
            :   .||.:..:| ...:|:         |.|:.|   :||
Mouse   510 SHDPVLHRDDLES-LLNEHSFDGILQWAIQSMSRPLAETPP 549

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
touNP_001097270.1 HAT_MBD 953..1027 CDD:238691
ZapA 1021..1127 CDD:294720
MAP7 1043..1198 CDD:283355
RILP-like 1085..>1179 CDD:304877
DDT 1255..1317 CDD:280886
WHIM1 1406..1455 CDD:292246
WHIM3 2190..2224 CDD:292248
PHD_BAZ2A_like 2640..2685 CDD:277020 7/44 (16%)
RanBP2-type Zn finger 2640..2659 CDD:275375 4/18 (22%)
RanBP2-type Zn finger 2680..2698 CDD:275376 5/17 (29%)
PHD 2695..2744 CDD:279022 21/61 (34%)
Bromo_BAZ2A_B_like 3027..3123 CDD:99935
AireNP_033776.1 LXXLL motif 1 8..12
Sp100 17..103 CDD:281203
LXXLL motif 2 64..68
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 109..177 14/85 (16%)
Nuclear localization signal. /evidence=ECO:0000255 114..134 3/19 (16%)
SAND 198..264 CDD:128554 12/65 (18%)
PHD1_AIRE 300..342 CDD:277014 20/46 (43%)
LXXLL motif 3 414..418 1/3 (33%)
PHD2_AIRE 433..475 CDD:277015 7/47 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 472..514 12/41 (29%)
LXXLL motif 4 520..524 1/4 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0383
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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