DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tou and PHF21B

DIOPT Version :9

Sequence 1:	NP_001097270.1	Gene:	tou / 36241	FlyBaseID:	FBgn0033636	Length:	3131	Species:	Drosophila melanogaster
Sequence 2:	NP_612424.1	Gene:	PHF21B / 112885	HGNCID:	25161	Length:	531	Species:	Homo sapiens

Alignment Length:	475	Identity:	97/475 - (20%)
Similarity:	138/475 - (29%)	Gaps:	177/475 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  2373 MQQQQQQQQLAQQQQQQQQGSGAGNSLNPSSFNERTMALAAAAAASGPGNATGVANSAVVAGATP 2437
            |:.|.:.:.||.:..:.|.|.      .....:||...:||.:.....|..|.|..:.....:..
Human     1 MELQSRPEALAVELARHQNGD------LKKQLHERQPRIAALSDKQALGTITAVPVTGPQVSSLQ 59

  Fly  2438 CESGSGEPNSGNASPASNCDSDRDEKVEQIPKGL--VQWRDAVSRSHTTAQLAMALYVLESCVAW 2500
            ..:|.|........|.:           .||..|  ...||...:...|.|.|..:.|
Human    60 RLAGQGAAVLPQVRPKT-----------LIPDSLPVAPGRDRPPKQPPTFQKATVVSV------- 106

  Fly  2501 DKSIMKAYATKNKS--------SKKKSSAKKQATPSKKQQQKKNKKEQQLTPNG------KESKS 2551
             |:...|..|.|.:        |:.::.|:..|..|            .|:..|      ..|.|
Human   107 -KNPSPALPTANNTVSHVPAPGSQPQALAEPAALAS------------PLSSAGVAYAIISTSPS 158

  Fly  2552 KSAINKPENQAPL---SIKINLKALAQNGQ---------------CLLKTKTPPILTKSPTASPS 2598
            .:|...|.....:   |||:....::.:.:               |.|...:.|:...||:.|||
Human   159 NAAAMAPSTAVSVVSDSIKVQPLLISADNKPPPRLLSSPHPATHHCPLHPSSLPLTPPSPSLSPS 223

  Fly  2599 ------------------------SHPNTSDSDSDFGKRTKKKSGG------------------- 2620
                                    |.|.| :..|...:.||||...
Human   224 PLHGIFQVIIIQPQVQTQPESTAESRPPT-EEPSQGAQATKKKKEDRPPTQENPEKIAFMVALGL 287

  Fly  2621 ----------------KRRRSANNTNSSKY--------SNSLQNCQFCTSGENEDKLLLCDGCDK 2661
                            |||.:||...|...        ||.|.|..|.|:..|||.
Human   288 VTTEHLEEIQSKRQERKRRSTANPAYSGLLETERKRLASNYLNNPLFLTARANEDP--------- 343

  Fly  2662 GYHTYCFKPKMDNIPDGDWYCYECVNKATNERKCIVC-GGHRPSPVGKMIYCDLCPRAYHADCYI 2725
                 |:|                 |:.|::..|..| .|....|      |..||.|||..|..
Human   344 -----CWK-----------------NEITHDEHCAACKRGANLQP------CGTCPGAYHLSCLE 380

  Fly  2726 PPLLKVPRGKWYCHGCISRA 2745
            |||...|:|.|.|..|..:|
Human   381 PPLKTAPKGVWVCPRCQQKA 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tou	NP_001097270.1	HAT_MBD	953..1027	CDD:238691
		ZapA	1021..1127	CDD:294720
		MAP7	1043..1198	CDD:283355
		RILP-like	1085..>1179	CDD:304877
		DDT	1255..1317	CDD:280886
		WHIM1	1406..1455	CDD:292246
		WHIM3	2190..2224	CDD:292248
		PHD_BAZ2A_like	2640..2685	CDD:277020	8/44 (18%)
		RanBP2-type Zn finger	2640..2659	CDD:275375	6/18 (33%)
		RanBP2-type Zn finger	2680..2698	CDD:275376	3/17 (18%)
		PHD	2695..2744	CDD:279022	19/49 (39%)
		Bromo_BAZ2A_B_like	3027..3123	CDD:99935
PHF21B	NP_612424.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	79..99		5/19 (26%)
		Nuc_recep-AF1	108..193	CDD:288658	16/96 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..222		5/37 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	238..277		8/39 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	295..314		5/18 (28%)
		PHD_PHF21B	354..396	CDD:276999	18/47 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	507..531
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0383
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900