DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tou and BAZ1A

DIOPT Version :9

Sequence 1:NP_001097270.1 Gene:tou / 36241 FlyBaseID:FBgn0033636 Length:3131 Species:Drosophila melanogaster
Sequence 2:NP_038476.2 Gene:BAZ1A / 11177 HGNCID:960 Length:1556 Species:Homo sapiens


Alignment Length:2365 Identity:420/2365 - (17%)
Similarity:668/2365 - (28%) Gaps:1151/2365 - (48%)


- Green bases have known domain annotations that are detailed below.


  Fly   919 ANAHMETSTDSESVAAESGLSESESEDANILNVAELRV--PLELGW-----KRETVIRGLTKQGQ 976
            ||.|: .|.|.|::.. |...:||::..:..|..:...  ||...:     |:|.....:.|..|
Human   149 ANGHV-NSVDGETIII-SDSDDSETQSCSFQNGKKKDAIDPLLFKYKVQPTKKELHESAIVKATQ 211

  Fly   977 I--------RGEVTYYAPGSTTPLKSNGQVFAILEQQPSNLS-----RENFSFSARAIVGSFLQP 1028
            |        |.::..:......|  .:|    :::.:.|:||     .::||:        |...
Human   212 ISRRKHLFSRDKLKLFLKQHCEP--QDG----VIKIKASSLSTYKIAEQDFSY--------FFPD 262

  Fly  1029 APPPY----AN-----DGEYIRMTDEDVAKRLEDLKVFTRQTLNVEQRIEIAKQQQAMRDAKKLQ 1084
            .||.:    ||     ..:.|.::.||        .|..:|||       .:.:.:|.::..||.
Human   263 DPPTFIFSPANRRRGRPPKRIHISQED--------NVANKQTL-------ASYRSKATKERDKLL 312

  Fly  1085 KEE----LARNKEKARQEKNSKLEQQRKDKELKNQQAVEERKKRQEELDRLKQEELLKKQQEKEK 1145
            |:|    ||..|.|.::||...||.::|:|        |:::|::|||.::.:||.|||::|||:
Human   313 KQEEMKSLAFEKAKLKREKADALEAKKKEK--------EDKEKKREELKKIVEEERLKKKEEKER 369

  Fly  1146 RRQEAILAKEQELQKQKEMLLAAEMERERRRQHMSLIRMLELRRKFEDREKKKHQLVLDRLLLRE 1210
                                |..|.|:||.:                               |||
Human   370 --------------------LKVEREKEREK-------------------------------LRE 383

  Fly  1211 RRMAERKRDAEILQLIRRPNEDSEMPQELVIPELDRIAGNRLPGQAMADLLMVFEFLHNFGETLG 1275
                |:::..|.|:...:|.||.|......:||...:. .|||.:...|.|||.|||:.|||.  
Human   384 ----EKRKYVEYLKQWSKPREDMECDDLKELPEPTPVK-TRLPPEIFGDALMVLEFLNAFGEL-- 441

  Fly  1276 FDM-ESLP---SLQNLHDALM-SDSNAD-----------------------AEEELLSVMTHLLV 1312
            ||: :..|   :|:.|.:||: :||...                       |:|:|....|..|.
Human   442 FDLQDEFPDGVTLEVLEEALVGNDSEGPLCELLFFFLTAIFQAIAEEEEEVAKEQLTDADTKDLT 506

  Fly  1313 CAIEDPGVPN--------------PGRHTTLLGQSLRNADITNSNVSEILRIYLYA------TAT 1357
            .|:::...|.              |..|.   |.||::.|:.:..:|||||:::.|      :|.
Human   507 EALDEDADPTKSALSAVASLAAAWPQLHQ---GCSLKSLDLDSCTLSEILRLHILASGADVTSAN 568

  Fly  1358 GEVR-QMHG---ITVDRERERRVPDHHQLDSDTTTHSHSVKNQEYYKLLHENDTWKLSQSLKDRP 1418
            .:.| |..|   .|.|...|.|                 :.|....|.|.       |.|:.|  
Human   569 AKYRYQKRGGFDATDDACMELR-----------------LSNPSLVKKLS-------STSVYD-- 607

  Fly  1419 FVALNPTRKAQMLAHLCNDLLMNKAVLRQIDGSLETCAQMRKEKYMTDMKVRKYKALHMRKARIE 1483
               |.|..|.::|..||..||...:....|:..::...|.::|       .|:.||...||.|.|
Human   608 ---LTPGEKMKILHALCGKLLTLVSTRDFIEDYVDILRQAKQE-------FRELKAEQHRKEREE 662

  Fly  1484 AYERAQAEREAAMQALMAQQKLDAERLKAEEEAKAAAAEEAAAAAGTDGEATKGGSPNGEKPEDG 1548
            |..|.:..:|..::....:.|...|:||.:|:..:.|....       ||         |:.||.
Human   663 AAARIRKRKEEKLKEQEQKMKEKQEKLKEDEQRNSTADISI-------GE---------EEREDF 711

  Fly  1549 DQNEEGAAKEPQQQQQQPMEVDGVVDEASLVSPAKTIIQTDNSLTPSKQDMPTPTYQINGSSTPT 1613
            |.:.|  :|:.:|:     |:|                          |||.|......||....
Human   712 DTSIE--SKDTEQK-----ELD--------------------------QDMVTEDEDDPGSHKRG 743

  Fly  1614 TSGVTGGDMNVLLQAKKSGARNSINDEHHHDVSIIDDDLSDLDSEITNVEEDEDNRLSADELQKK 1678
            ..|..|  .|...:..:....|.:..|                    .:..||:..|..:..:|:
Human   744 RRGKRG--QNGFKEFTRQEQINCVTRE--------------------PLTADEEEALKQEHQRKE 786

  Fly  1679 LDKIVRASLNCKEALEKSTNQLRAAC-----FGQDRFWRRYWKLPKAGGIFIEALESAQNDICDY 1738
                       ||.|||.  |...||     .|:||.:||||..|...|:|||.         ||
Human   787 -----------KELLEKI--QSAIACTNIFPLGRDRMYRRYWIFPSIPGLFIEE---------DY 829

  Fly  1739 HEALEAMDDKKDANDEKENSENEKDVAAESSEQPMEVDESITKLEDGVPASDVGMPE-SNQQNAH 1802
            ....|                                              |:.:|. |:.||..
Human   830 SGLTE----------------------------------------------DMLLPRPSSFQNNV 848

  Fly  1803 QDEEDDDDDVTEINKVEPEIVDLGDDDDDAAPPLPKIEPPRPEIKVKSEMELMGPPPTTMISTKT 1867
            |.::                                     |::..|:...||..          
Human   849 QSQD-------------------------------------PQVSTKTGEPLMSE---------- 866

  Fly  1868 DFEAEIKIPSMPGILMPPTLNNNNTNNNNNNNGSDNCDKLETGLGLGQQQQNFSQSVIKTEDVKK 1932
                                                                             
Human   867 ----------------------------------------------------------------- 866

  Fly  1933 EDDCIIVSTSSVDDTPKWFSIVRREVPLISELPAEEGGVVGQELQISYANQNCSAQLQLQGHPWD 1997
                   |||::|..|:..|:         :||.          .:...|:.|            
Human   867 -------STSNIDQGPRDHSV---------QLPK----------PVHKPNRWC------------ 893

  Fly  1998 LINNMQYYSIPMDECKVDTSKLGNECIFSLSGLDEKQMLAKVEEYKAHKVESKNGLGSPHRHHET 2062
                  :||                   |...||:             .:|:.|..|  ||....
Human   894 ------FYS-------------------SCEQLDQ-------------LIEALNSRG--HRESAL 918

  Fly  2063 KDDEEQAKLKLDKEIDTEMETDADDLAGKEKFFRLRSDVP-PDTGGGVSEGTD----------VK 2116
            |:...|.|.::..::....|         |||.  .||.| ||:....|.|..          .:
Human   919 KETLLQEKSRICAQLARFSE---------EKFH--FSDKPQPDSKPTYSRGRSSNAYDPSQMCAE 972

  Fly  2117 PKIELRLDEALSQAYYHNIANMSLSSVQTYIPIDIPLPLSMTPDEHRL----LEQVKLAGFPERV 2177
            .::||||.:.|                     :||         |.|:    |..:|:.      
Human   973 KQLELRLRDFL---------------------LDI---------EDRIYQGTLGAIKVT------ 1001

  Fly  2178 HGVYVPRRQRYGWWQ---------LDDEQKLRQLLKTLNPSGLRERELQENLQ-----RFLGLEQ 2228
                    .|:.|..         |.:|.|...::||:| ..:.|.|:.|..:     |.||::.
Human  1002 --------DRHIWRSALESGRYELLSEENKENGIIKTVN-EDVEEMEIDEQTKVIVKDRLLGIKT 1057

  Fly  2229 PLGVNYKLKSDIDFPEEFLMPDKKGDWNPKVAKRVELALIEQLESLEDKVASASMQLKNWQLPNR 2293
                                                                        :.|:.
Human  1058 ------------------------------------------------------------ETPST 1062

  Fly  2294 VESELTLDSQEDVTEEDFVSIIPMIRERIIDLEANIERRYLKPPLGSQTGDAHLAVIAQNQHTTT 2358
            |.:..:       |.:...|::..:...:..:|..||||:||.||.:.                 
Human  1063 VSTNAS-------TPQSVSSVVHYLAMALFQIEQGIERRFLKAPLDAS----------------- 1103

  Fly  2359 QTQNSASAAAYLLQMQQQQQQQQLAQQQQQQQQGSGAGNSLNPSSFNERTMALAAAAAASGPGNA 2423
                                                                             
Human  1104 ----------------------------------------------------------------- 1103

  Fly  2424 TGVANSAVVAGATPCESGSGEPNSGNASPASNCDSDRDEKVEQIPKGLVQWRDAVSRSHTTAQLA 2488
                                             ||.|..|..     |.:||:::..|.:.:|:.
Human  1104 ---------------------------------DSGRSYKTV-----LDRWRESLLSSASLSQVF 1130

  Fly  2489 MALYVLESCVAWDKSIMKAYATKNKSSKKKSSAKKQATPSKKQQQKKNKKEQQLTPNGKESKSKS 2553
            :.|..|:..|.|.|||:.|                                              
Human  1131 LHLSTLDRSVIWSKSILNA---------------------------------------------- 1149

  Fly  2554 AINKPENQAPLSIKINLKALAQNGQCLLKTKTPPILTKSPTASPSSHPNTSDSDSDFGKRTKKKS 2618
                                                                             
Human  1150 ----------------------------------------------------------------- 1149

  Fly  2619 GGKRRRSANNTNSSKYSNSLQNCQFCTSGENEDKLLLCDGCDKGYHTYCFKPKMDNIPDGDWYCY 2683
                                 .|:.|....:.:.::||||||:|:||||.:||:..:|:|||:|.
Human  1150 ---------------------RCKICRKKGDAENMVLCDGCDRGHHTYCVRPKLKTVPEGDWFCP 1193

  Fly  2684 ECVNKATNERKCIVCGGHRPSPVGKMIYCDLCPRAYHADCYIPPLLKVPRGKWYCHGCISRAPPP 2748
            ||                                                             .|
Human  1194 EC-------------------------------------------------------------RP 1197

  Fly  2749 KKRSAGGTSGSSSKSRRDRDRESGGSAKRRSDNSKTPAMEHMQQQQMPLAG-----------GDS 2802
            |:||                        ||..:.:.|::|..:..:..:.|           |.|
Human  1198 KQRS------------------------RRLSSRQRPSLESDEDVEDSMGGEDDEVDGDEEEGQS 1238

  Fly  2803 HHHHHQQPPSLNSSHDESMNSLPAAPLSPAHSVVSATNYDDQHHANNSVDGSSRFHAHLIPPSNN 2867
            ....::.....:.|.:|...|||..........|..       ....|...|||           
Human  1239 EEEEYEVEQDEDDSQEEEEVSLPKRGRPQVRLPVKT-------RGKLSSSFSSR----------- 1285

  Fly  2868 GTAALLEDVPGGANVMPGVYP----VYTPVAAGNFSAG----LINQAPVQPAMPFANVVAMSPR- 2923
                       |....||.||    ..||....:...|    .||.||....... .:.:.|.| 
Human  1286 -----------GQQQEPGRYPSRSQQSTPKTTVSSKTGRSLRKINSAPPTETKSL-RIASRSTRH 1338

  Fly  2924 ------------AVTPTRTRTPTPTPAPTPPPPPPTPLLMQASPTATALHVNACQSPPQQQHAQL 2976
                        .::|.|.|....:...||          :.||......|.|.:|..|.:...:
Human  1339 SHGPLQADVFVELLSPRRKRRGRKSANNTP----------ENSPNFPNFRVIATKSSEQSRSVNI 1393

  Fly  2977 MTMPSPPAIGVGTATNQMSPPPINIHAIQEAKEKLKQEKKEKHATKKL------------MKELA 3029
            .:..|                      :||::.|.:..|::......:            :.||:
Human  1394 ASKLS----------------------LQESESKRRCRKRQSPEPSPVTLGRRSSGRQGGVHELS 1436

  Fly  3030 VCKTLLGEMELHEDSWPFLLPVNTKQFPTYRKIIKTPMDLSTIKKKLQDLSYKTREDFCVDVRQI 3094
            ..:.|:.|:..|:||||||..|:..|.|.|..|||.|:.|:.|::|:....||...:|..|:..:
Human  1437 AFEQLVVELVRHDDSWPFLKLVSKIQVPDYYDIIKKPIALNIIREKVNKCEYKLASEFIDDIELM 1501

  Fly  3095 FDNCEMFNEDDSPVGKAGHGMRKFF 3119
            |.||..:|..::...|||..::.||
Human  1502 FSNCFEYNPRNTSEAKAGTRLQAFF 1526

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
touNP_001097270.1 HAT_MBD 953..1027 CDD:238691 16/93 (17%)
ZapA 1021..1127 CDD:294720 29/118 (25%)
MAP7 1043..1198 CDD:283355 39/158 (25%)
RILP-like 1085..>1179 CDD:304877 30/97 (31%)
DDT 1255..1317 CDD:280886 25/89 (28%)
WHIM1 1406..1455 CDD:292246 12/48 (25%)
WHIM3 2190..2224 CDD:292248 11/47 (23%)
PHD_BAZ2A_like 2640..2685 CDD:277020 20/44 (45%)
RanBP2-type Zn finger 2640..2659 CDD:275375 5/18 (28%)
RanBP2-type Zn finger 2680..2698 CDD:275376 4/17 (24%)
PHD 2695..2744 CDD:279022 0/48 (0%)
Bromo_BAZ2A_B_like 3027..3123 CDD:99935 35/93 (38%)
BAZ1ANP_038476.2 Required for interaction with NCOR1. /evidence=ECO:0000269|PubMed:17519354 1..133
Required for association with the CHRAC1/POLE3 complex 1..128
WAC_Acf1_DNA_bd 23..122 CDD:313708
DDT 422..485 CDD:214726 19/64 (30%)
WHIM1 590..635 CDD:317926 15/73 (21%)
Neuromodulin_N <645..788 CDD:331332 43/231 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 662..754 30/142 (21%)
Interaction with SMARCA5 667..933 89/594 (15%)
WSD 800..926 CDD:317927 47/370 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 841..877 13/154 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 941..966 8/26 (31%)
PHD_BAZ1A 1150..1195 CDD:277097 20/44 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1202..1376 38/213 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1399..1431 4/31 (13%)
Bromo_Acf1_like 1423..1535 CDD:99936 35/104 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5076
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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