DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tou and CHD4

DIOPT Version :9

Sequence 1:	NP_001097270.1	Gene:	tou / 36241	FlyBaseID:	FBgn0033636	Length:	3131	Species:	Drosophila melanogaster
Sequence 2:	NP_001264.2	Gene:	CHD4 / 1108	HGNCID:	1919	Length:	1912	Species:	Homo sapiens

Alignment Length:	563	Identity:	114/563 - (20%)
Similarity:	192/563 - (34%)	Gaps:	199/563 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  2285 LKNWQLPNRVESELTLDSQEDVTEEDFVSI-------------IPMIRERIIDLEANIERRYLKP 2336
            |.|...|...|:|  .|.:||::|.:...:             ||..:.:      ..||..|..
Human    24 LNNSLPPPHPENE--EDPEEDLSETETPKLKKKKKPKKPRDPKIPKSKRQ------KKERMLLCR 80

  Fly  2337 PLGSQTGDAHLAVIAQNQHTTTQTQNSAS----AAAYLLQMQQQQQQQQLAQQQQQQQQGSGAGN 2397
            .||..:|:.. ..:.:.:....::.:..|    ......::..:::::..:::::::::.....:
Human    81 QLGDSSGEGP-EFVEEEEEVALRSDSEGSDYTPGKKKKKKLGPKKEKKSKSKRKEEEEEEDDDDD 144

  Fly  2398 SLNPSS----------------FNE---RTMA--------LAAAAAASGPGNATGVANSAVVAGA 2435
            |..|.|                |:|   ||:.        :....||..|..|  |:...:|.||
Human   145 SKEPKSSAQLLEDWGMEDIDHVFSEEDYRTLTNYKAFSQFVRPLIAAKNPKIA--VSKMMMVLGA 207

  Fly  2436 TPCESGSGEPNSGNASPASNCDSDRDEKVEQIPKGLVQWRDAVSRSHTTAQLAMALYVLESCVAW 2500
            ...|..:..|..|:                             |.:...|..|.|:.|:||.|.
Human   208 KWREFSTNNPFKGS-----------------------------SGASVAAAAAAAVAVVESMVT- 242

  Fly  2501 DKSIMKAYATKNKSSK-------KKSSAKKQATPSKKQQQKKNKKEQQLTPNGKESKSKSAINKP 2558
                    ||:.....       :|:..|:...|:.:::.|.:.:    .|:.|:.       ||
Human   243 --------ATEVAPPPPPVEVPIRKAKTKEGKGPNARRKPKGSPR----VPDAKKP-------KP 288

  Fly  2559 ENQAPLSIKINLKALAQNGQCLLKTKTPPILTKSPTASPSSHPNTSDSDSDFG------------ 2611
            :..|||.||:        |....|.|           ..||..:..|.:|||.
Human   289 KKVAPLKIKL--------GGFGSKRK-----------RSSSEDDDLDVESDFDDASINSYSVSDG 334

  Fly  2612 ------------KRTKKKSGGKRRRSA---NNTNSSKYSNSLQNCQFCTSGENEDKLLLCDGCDK 2661
                        :.||||..|:...:|   ..|:...|      |:.|..|   .:::|||.|.:
Human   335 STSRSSRSRKKLRTTKKKKKGEEEVTAVDGYETDHQDY------CEVCQQG---GEIILCDTCPR 390

  Fly  2662 GYHTYCFKPKMDNIPDGDWYCYECVNKATN-ERK---------------------------CIVC 2698
            .||..|..|.|:..|:|.|.|..|..:... |.|                           |.||
Human   391 AYHMVCLDPDMEKAPEGKWSCPHCEKEGIQWEAKEDNSEGEEILEEVGGDLEEEDDHHMEFCRVC 455

  Fly  2699 GGHRPSPVGKMIYCDLCPRAYHADCYIPPLLKVPRGKWYCHGC 2741
                 ...|:::.||.||.:||..|..|||.::|.|:|.|..|
Human   456 -----KDGGELLCCDTCPSSYHIHCLNPPLPEIPNGEWLCPRC 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tou	NP_001097270.1	HAT_MBD	953..1027	CDD:238691
		ZapA	1021..1127	CDD:294720
		MAP7	1043..1198	CDD:283355
		RILP-like	1085..>1179	CDD:304877
		DDT	1255..1317	CDD:280886
		WHIM1	1406..1455	CDD:292246
		WHIM3	2190..2224	CDD:292248
		PHD_BAZ2A_like	2640..2685	CDD:277020	16/44 (36%)
		RanBP2-type Zn finger	2640..2659	CDD:275375	6/18 (33%)
		RanBP2-type Zn finger	2680..2698	CDD:275376	6/45 (13%)
		PHD	2695..2744	CDD:279022	19/47 (40%)
		Bromo_BAZ2A_B_like	3027..3123	CDD:99935
CHD4	NP_001264.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..157		21/141 (15%)
		CHDNT	164..216	CDD:285335	13/53 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	243..360		29/146 (20%)
		PHD1_CHD_II	372..414	CDD:277006	17/50 (34%)
		PHD2_CHD_II	451..493	CDD:277007	18/46 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..538
		CHROMO	<540..577	CDD:237991
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	578..603
		CHROMO	622..676	CDD:214605
		SNF2_N	729..1025	CDD:278600
		DEXDc	746..904	CDD:238005
		DEAH box	873..876
		Helicase_C	1068..1164	CDD:278689
		DUF1087	1302..1352	CDD:283996
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1344..1401
		DUF1086	1385..1521	CDD:283992
		Neuromodulin	<1517..1649	CDD:284117
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1525..1562
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1570..1589
		Required for interaction with PCNT. /evidence=ECO:0000269\|PubMed:17626165	1577..1912
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1594..1644
		CHDCT2	1726..1896	CDD:285336
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0383
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900