DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tou and brd8a

DIOPT Version :9

Sequence 1:	NP_001097270.1	Gene:	tou / 36241	FlyBaseID:	FBgn0033636	Length:	3131	Species:	Drosophila melanogaster
Sequence 2:	XP_017208471.1	Gene:	brd8a / 100003763	ZFINID:	ZDB-GENE-091113-54	Length:	820	Species:	Danio rerio

Alignment Length:	971	Identity:	189/971 - (19%)
Similarity:	313/971 - (32%)	Gaps:	302/971 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  2198 KLRQLLKTLNPSGLRERELQENLQRFLGLEQPLGVNYKLKSDIDFPEEFLMPDKKGDWNPKVAKR 2262
            |.:.||...:|..:||:....:.....|.:..:.|:..:|       .|..|.:..||..:  |.
Zfish     7 KHKLLLGPTDPWSIREKLCLASSVMKSGDQNWVSVSRAIK-------PFAEPGRPPDWFSQ--KH 62

  Fly  2263 VELALIEQLESLEDKVASASMQLKNWQLPNRVESEL--TLDSQEDVTEEDFVSIIPMIRERIIDL 2325
            ......|.||:.|              .|.|...|.  .:::.|||.      :..:..|||.:|
Zfish    63 CASQYSELLETTE--------------APKRKRGEKGEVVETVEDVI------VRRLTAERIEEL 107

  Fly  2326 EANIERRYLKPPLGSQTGDAHLAVIAQNQHTTTQTQNSASAAAYLLQMQQQQQQQQLAQQQQQQQ 2390
                 :|.:|.              .|.:|...:.::....|.: |..:.::..:::.:.::|::
Zfish   108 -----KRLIKD--------------TQEKHRKLKRESELIQAGH-LDSKLEELWEEIVRSRKQEE 152

  Fly  2391 QGSGAGNSLNPSSFNERTMALAAAAAASGPGNATGVANSAVVAGAT------PCESGSGEPNSGN 2449
            :.:........:::..|      .|..:.|.....|...: .:||.      |....|.:|.|..
Zfish   153 EEAEVKRKATDAAYQAR------QAVKNTPKRVPSVTVRS-PSGACSPSLDFPIGDSSEDPGSTA 210

  Fly  2450 ASPASNCDSDRDEKVEQIP-KGLVQWRDAVSRSHTTAQLAMALYVLESCVAWDKSIMKAYATKNK 2513
            |.|....      .:.::| .|:|:           |.|...|                    ::
Zfish   211 AGPTVFV------PLTELPGPGVVE-----------ASLGSLL--------------------DE 238

  Fly  2514 SSKKKSSAKKQATPSKKQQQKKNKKEQQLTPNGK------ESKSKSAINKPENQAPLSIKINLKA 2572
            |::||...:| .||.......:..|:..|.|...      |:.|.......|||...|   :|.|
Zfish   239 STQKKLLGQK-ITPPPSPLLSELLKKGSLLPTSPRLAVEGETPSNQLAGSHENQMMTS---SLPA 299

  Fly  2573 -LAQNGQCLLKTKTPPILTKSPTASPSSHPNTSDSDSDFGKRTK------KKSGGKRRRSANNTN 2630
             .|..|...|..    :|...|...||...:.:.:||.....|.      ..|.|:....|:..|
Zfish   300 SQAATGAPTLSR----LLEAGPAQFPSQLSSLATADSAPSAATSAVDVVAPLSTGEGAAGASVDN 360

  Fly  2631 SSKYSNSLQNCQFCTSGENEDKLLLCDGCDKGYHTYCFKP-KMDNIPD--------GDWYCYECV 2686
            ..           ...|| ||.:.:         :|..:. .::.:.|        ||... |.:
Zfish   361 KE-----------AVLGE-EDLVTV---------SYMAEELDLETVGDIIAIIEEKGDENA-EAL 403

  Fly  2687 NKATNERKCIVC--------GGHRPSPVGKMIYCDLCPRAYHADCYIPP-LLKVPRGKWYCHGCI 2742
            :.|..|....:|        |...|:|     :..:||........:.| .|.:..|
Zfish   404 DAAVVEAALSLCEDTGHSLTGSWEPNP-----FRPICPEPSSTSADLDPHSLNLLEG-------- 455

  Fly  2743 SRAPPPKKRSAGGTSGSSSKSRRDRDRESGGSAKRRSDNSKTPAMEHMQQQQMPLAG----GDSH 2803
                   ||......||||           |.|:..|..|.|  :..:.|...|:.|    .|:.
Zfish   456 -------KREGPDACGSSS-----------GCAQMYSTPSST--VPSVPQDPTPIVGLNSEPDTP 500

  Fly  2804 HHHH------QQPPSLNS---------SHDESMNSLPAAPLSPAHSVVSATNYDDQHHANNSVDG 2853
            ...|      :||.||:|         :..:|.......|:...||  .....:::..|:::.:|
Zfish   501 RPEHTDQAQDEQPESLHSLIKSEAEEWTRSQSDTRSVDDPVIKQHS--KEVKEEEEEAASDAEEG 563

  Fly  2854 S-SRFHAHLIPPSNNGTAALLEDVPGGANVMPGVYPVYTPVAAGNFSAGLINQAPVQPAMPFANV 2917
            | |...:.|     .|..|  ||. ||......||               :::|
Zfish   564 SVSEMKSGL-----EGDGA--EDC-GGEEDGDAVY---------------LSEA----------- 594

  Fly  2918 VAMSPRAVTPTRTRTPTPTPAPTPPPPPPTPLLMQASPTATALHVNACQSPPQQQHAQLMTMPSP 2982
                               ...|...||.:     .|....::|.   .|...|.|....::||.
Zfish   595 -------------------DGDTELDPPAS-----ESEDGYSMHT---ASSSIQLHTTADSIPSS 632

  Fly  2983 PAIGVGTATNQMSPPPINIHAIQEAKEKLKQEKKEKHATKKLMKELAVCKTLLGEMELHEDSWPF 3047
            |      |::|.|       ...|.:|.::.:|..|.|...:.:..|          .|..:..|
Zfish   633 P------ASSQFS-------ICSEDQEAIQAQKIWKKAIMLVWRAAA----------NHRYANVF 674

  Fly  3048 LLPVNTKQFPTYRKIIKTPMDLSTIKKKLQDLSYKTREDFCVDVRQIFDNCEMFNEDDSPV 3108
            |.||.....|.|..|:..|||||||||.:::...:|..:|..|:..:|.|..|:|..|..|
Zfish   675 LQPVTDDIAPGYHSIVHRPMDLSTIKKNIENGLIRTTAEFQRDIMLMFQNAVMYNSSDHDV 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tou	NP_001097270.1	HAT_MBD	953..1027	CDD:238691
		ZapA	1021..1127	CDD:294720
		MAP7	1043..1198	CDD:283355
		RILP-like	1085..>1179	CDD:304877
		DDT	1255..1317	CDD:280886
		WHIM1	1406..1455	CDD:292246
		WHIM3	2190..2224	CDD:292248	6/25 (24%)
		PHD_BAZ2A_like	2640..2685	CDD:277020	8/53 (15%)
		RanBP2-type Zn finger	2640..2659	CDD:275375	4/18 (22%)
		RanBP2-type Zn finger	2680..2698	CDD:275376	3/17 (18%)
		PHD	2695..2744	CDD:279022	9/57 (16%)
		Bromo_BAZ2A_B_like	3027..3123	CDD:99935	27/82 (33%)
brd8a	XP_017208471.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900