DRSC/TRiP Functional Genomics Resources

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Protein Alignment en and HOXD13

DIOPT Version :9

Sequence 1:NP_523700.2 Gene:en / 36240 FlyBaseID:FBgn0000577 Length:552 Species:Drosophila melanogaster
Sequence 2:NP_000514.2 Gene:HOXD13 / 3239 HGNCID:5136 Length:343 Species:Homo sapiens


Alignment Length:354 Identity:87/354 - (24%)
Similarity:135/354 - (38%) Gaps:89/354 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   204 PFEASRSQTATPSA------FTRVDLLEFSRQQQAAAAAATAAMMLERANFLNCFNPAAYPRIHE 262
            |..:|.|..|..:|      |....:...:...:||||||.||.....|:..      |||...|
Human    23 PASSSSSSVAAAAASGQCRGFLSAPVFAGTHSGRAAAAAAAAAAAAAAASGF------AYPGTSE 81

  Fly   263 EIVQSRLRRSAANAVIPPPMSSKMSDANPEKSALGSLCKAVSQIGQPAAPTMTQPPLSSSASSLA 327
            ....|  ..|:::||:                           ..:|.||...:.|..:.|::.|
Human    82 RTGSS--SSSSSSAVV---------------------------AARPEAPPAKECPAPTPAAAAA 117

  Fly   328 SPPPASNASTISSTSSVATSSSSSSSGCSSAASSLNSSPSSRLGA-------SGSGVNASSPQPQ 385
            :||.|. |............|...|.|.....::|.|||.:.||.       ..||:.:||....
Human   118 APPSAP-ALGYGYHFGNGYYSCRMSHGVGLQQNALKSSPHASLGGFPVEKYMDVSGLASSSVPAN 181

  Fly   386 PIPP-PSAVSRDSGMES----------------SDDTRSET-------GSTTTEGGKNEMWPAWV 426
            .:|. ...||...|..|                |.:.|.|.       .|.|...|    |.:.|
Human   182 EVPARAKEVSFYQGYTSPYQHVPGYIDMVSTFGSGEPRHEAYISMEGYQSWTLANG----WNSQV 242

  Fly   427 YCTRYSDRPSSGPRYRRPKQPKDKTNDE---------KRPRTAFSSEQLARLKREFNENRYLTER 482
            |||:  |:| .|..:.:...|.|...::         ::.|..::..||..|:.|:..|:::.:.
Human   243 YCTK--DQP-QGSHFWKSSFPGDVALNQPDMCVYRRGRKKRVPYTKLQLKELENEYAINKFINKD 304

  Fly   483 RRQQLSSELGLNEAQIKIWFQNKRAKIKK 511
            :|:::|:...|:|.|:.|||||:|.|.||
Human   305 KRRRISAATNLSERQVTIWFQNRRVKDKK 333

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
enNP_523700.2 Homeobox 457..510 CDD:278475 18/52 (35%)
Engrail_1_C_sig 512..541 CDD:287495 87/354 (25%)
HOXD13NP_000514.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..28 1/4 (25%)
HoxA13_N 39..174 CDD:289085 39/170 (23%)
polyalanine repeat 57..71 8/13 (62%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 78..115 10/65 (15%)
homeodomain 277..333 CDD:238039 18/55 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 97 1.000 Inparanoid score I5040
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.960

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