Protein Alignment en and HOXA13

DIOPT Version :9

• Sequence 1: NP_523700.2
• Gene: en / 36240
• FlyBaseID: FBgn0000577
• Length: 552
• Species: Drosophila melanogaster
• Sequence 2: NP_000513.2
• Gene: HOXA13 / 3209
• HGNCID: 5102
• Length: 388
• Species: Homo sapiens
• Alignment Length: 426
• Identity: 98/426 - (23%)
• Similarity: 148/426 - (34%)
• Gaps: 143/426 - (33%)

  Fly   170 KPSLAFSISN---ILSDRFGDVQKPGKSMENQASIFRPFEASRSQTATPSAFTRVDLL----EFS 227
            :|::.|...|   :::|..      .|:||..|:......|:.:..|....|......    .||
Human    13 EPTVMFLYDNGGGLVADEL------NKNMEGAAAAAAAAAAAAAAGAGGGGFPHPAAAAAGGNFS 71

  Fly   228 RQQQAAAAAATAAMMLERANFLNCFNPAAYPRIHEEIVQSRLRRSAANAVIPPPMSSKMSDANPE 292
            ....||||||.||.        .|.|..|:|        :.|...||:|     .||...:|.|.
Human    72 VAAAAAAAAAAAAN--------QCRNLMAHP--------APLAPGAASA-----YSSAPGEAPPS 115

  Fly   293 KSALGSLCKAVSQIGQPAAPTMTQPPLSSSASSLASPPPASNASTISSTSSVATSSSSSSSGCSS 357
            .:|..:...|.:     ||        :::|||...|.||..|         ...::...|.||:
Human   116 AAAAAAAAAAAA-----AA--------AAAASSSGGPGPAGPA---------GAEAAKQCSPCSA 158

  Fly   358 AASSLNSSPSSRLGASGSGVNASS---PQPQPI----PPPSAVS----RDSGMESSDDTRSETGS 411
            ||.|.:...:...|..|||....:   |.|..|    .|.||.:    .|..|:::.....|..|
Human   159 AAQSSSGPAALPYGYFGSGYYPCARMGPHPNAIKSCAQPASAAAAAAFADKYMDTAGPAAEEFSS 223

  Fly   412 TTTE-------------------------------GGKNEM--------------------WPAW 425
            ...|                               ||..|.                    |...
Human   224 RAKEFAFYHQGYAAGPYHHHQPMPGYLDMPVVPGLGGPGESRHEPLGLPMESYQPWALPNGWNGQ 288

  Fly   426 VYCTRYS---------------DRPSSGPRYRRPKQPKDKTNDEKRPRTAFSSEQLARLKREFNE 475
            :||.:..               ..||....|||          .::.|..::..||..|:||:..
Human   289 MYCPKEQAQPPHLWKSTLPDVVSHPSDASSYRR----------GRKKRVPYTKVQLKELEREYAT 343

  Fly   476 NRYLTERRRQQLSSELGLNEAQIKIWFQNKRAKIKK 511
            |:::|:.:|:::|:...|:|.|:.|||||:|.|.||
Human   344 NKFITKDKRRRISATTNLSERQVTIWFQNRRVKEKK 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
en	NP_523700.2	Homeobox	457..510	CDD:278475	20/52 (38%)
		Engrail_1_C_sig	512..541	CDD:287495	98/426 (23%)
HOXA13	NP_000513.2	HoxA13_N	85..222	CDD:403486	42/179 (23%)
		Homeobox	325..379	CDD:395001	20/53 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I5040
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960