DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment en and en2a

DIOPT Version :9

Sequence 1:	NP_523700.2	Gene:	en / 36240	FlyBaseID:	FBgn0000577	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_571119.2	Gene:	en2a / 30243	ZFINID:	ZDB-GENE-980526-167	Length:	265	Species:	Danio rerio

Alignment Length:	225	Identity:	108/225 - (48%)
Similarity:	134/225 - (59%)	Gaps:	40/225 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   318 PLSSSASSLASPPPASNASTISSTSSVATSSSSSSSGCSSAASSLNSSPSSRLGASGSGVNASSP 382
            |...|...:.|..||..|||           :.:|||                     |..|...
Zfish    76 PTGPSTGQVGSTVPAEEAST-----------THTSSG---------------------GKEAEIE 108

  Fly   383 QPQPIPPPSA-VSRDSGMESSDDTRSETGSTTTEGGKNEMWPAWVYCTRYSDRPSSGPRYRRPKQ 446
            ..:|:.|... |.:..|.||.....:..|.|    |:..:|||||||||||||||||||.|:||:
Zfish   109 SEEPLKPRGENVDQCLGSESDSSQSNSNGQT----GQGMLWPAWVYCTRYSDRPSSGPRSRKPKK 169

  Fly   447 PKDKTNDEKRPRTAFSSEQLARLKREFNENRYLTERRRQQLSSELGLNEAQIKIWFQNKRAKIKK 511
             |..:.::|||||||::|||.|||.||..||||||:|||.|:.||||||:|||||||||||||||
Zfish   170 -KAASKEDKRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELGLNESQIKIWFQNKRAKIKK 233

  Fly   512 STGSKNPLALQLMAQGLYNHTTVPLTKEEE 541
            ::|.||.||:.|||||||||:|.  :||::
Zfish   234 ASGVKNGLAIHLMAQGLYNHSTT--SKEDK 261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
en	NP_523700.2	Homeobox	457..510	CDD:278475	41/52 (79%)
en	NP_523700.2	Engrail_1_C_sig	512..541	CDD:287495	17/28 (61%)
en2a	NP_571119.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..142		22/101 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	155..180		15/25 (60%)
		Homeobox	179..232	CDD:278475	41/52 (79%)
		Engrail_1_C_sig	234..263	CDD:287495	17/30 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I7156
eggNOG	1	0.900	-	-		E1_KOG0493
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	217	1.000	Inparanoid score	I3574
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002003
OrthoInspector	1	1.000	-	-		mtm6346
orthoMCL	1	0.900	-	-		OOG6_106342
Panther	1	1.100	-	-	O	PTHR24341
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1139
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.820