DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment en and en2b

DIOPT Version :9

Sequence 1:	NP_523700.2	Gene:	en / 36240	FlyBaseID:	FBgn0000577	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_571115.1	Gene:	en2b / 30238	ZFINID:	ZDB-GENE-980526-40	Length:	261	Species:	Danio rerio

Alignment Length:	190	Identity:	105/190 - (55%)
Similarity:	130/190 - (68%)	Gaps:	19/190 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   364 SSPSSRLGASGSGVNASSPQPQPIPPPSAVSRDSGMESSDDTRSETGS------------TTTEG 416
            |:|.|...|..||...|||:.......:.:|.|..::|    |:|||.            ...:.
Zfish    75 SAPGSGQVAPVSGEGTSSPRAVNASKKTDISTDESLKS----RAETGDQCLSSDSDCSQRCAAQA 135

  Fly   417 GKNEMWPAWVYCTRYSDRPSSGPRYRRPKQPKDKTNDEKRPRTAFSSEQLARLKREFNENRYLTE 481
            .:..:|||||||||||||||||||.|:||: |..|.::|||||||::|||.|||.||..||||||
Zfish   136 KQPMLWPAWVYCTRYSDRPSSGPRSRKPKK-KTPTKEDKRPRTAFTAEQLQRLKNEFQNNRYLTE 199

  Fly   482 RRRQQLSSELGLNEAQIKIWFQNKRAKIKKSTGSKNPLALQLMAQGLYNHTTVPLTKEEE 541
            :|||.|:.||||||:|||||||||||||||:||:||.||:.|||||||||.||  ||:::
Zfish   200 QRRQALAQELGLNESQIKIWFQNKRAKIKKATGNKNTLAVHLMAQGLYNHATV--TKDDK 257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
en	NP_523700.2	Homeobox	457..510	CDD:278475	41/52 (79%)
en	NP_523700.2	Engrail_1_C_sig	512..541	CDD:287495	19/28 (68%)
en2b	NP_571115.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..125		16/53 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	152..176		15/24 (63%)
		Homeobox	175..228	CDD:278475	41/52 (79%)
		Engrail_1_C_sig	230..259	CDD:287495	19/30 (63%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I7156
eggNOG	1	0.900	-	-		E1_KOG0493
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	217	1.000	Inparanoid score	I3574
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002003
OrthoInspector	1	1.000	-	-		mtm6346
orthoMCL	1	0.900	-	-		OOG6_106342
Panther	1	1.100	-	-	O	PTHR24341
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1139
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	12	12.320